龚毅君个人简介

龚毅君

湖北省赤壁市人，

博士，讲师，硕士生导师

E-mail：23113271@qq.com

教育与研究经历：

2001年9月-2005年6月湖南大学化学化工学院化学专业学士

2005年9月-2007年6月湖南大学化学化工学院分析化学专业硕士研究生

2007年9月-2013年6月湖南大学化学化工学院分析化学专业博士研究生

2013年7月-2020年4月河南师范大学化学化工学院讲师

2020年4月-至今河南师范大学化学化工学院副教授

主讲课程：

分析化学、仪器分析、分析化学实验、仪器分析实验、综合分析实验

研究领域与兴趣：

荧光探针的设计合成与生物成像

功能化染料的设计与开发

主持的科研项目：

1. 河南省高等学校重点科研项目：基于罗丹明类似物的高效近红外荧光探针的设计合成及生物成像应用研究（项目编码：15A150013）

2. 2014年度湖南大学化学生物传感与计量学国家重点实验室开放课题

3. 河南师范大学国家级科研项目培育基金

4.国家自然科学基金青年项目：双光子比例型荧光纳米探针的构建及生物成像应用研究（项目编码：21605039）

5.第60批中国博士后科学基金面上资助一等资助（项目编码：2016M600579)

6.河南省高等学校重点科研项目：可调控近红外荧光成像体系用于急性肾损伤的早期诊断（项目编码：22A150013）

代表性成果：

1.Yi-jun Gong,*Qian Wang, Aiying Ma, Wenxue Shi, Yang Xiao, Peng Wang. Equivalent visualizing biothiols level in synergistically induced ferroptosis using a dual mechanism hybrid probe with excitation-independent sensing property. Sensors & Actuators: B. Chemical, 2025, 445, 138567.

2. Qian Wang , Panpan Wang , Yang Xiao , Suling Feng , Guisheng Zhang*, Yi- Jun Gong*. An asymmetrical flavylium based probe with large Stokes shift and near infrared emission for highly sensitive detecting and visualizing cellular drug induced H2S fluctuations. Talanta, 2024, 271, 125734.

3. Yijun Gong,* Panpan Wang, Hongchen Zhai, Yang Xiao, Qian Wang, Nana Ma, Guisheng Zhang,* Hua Zhang*. Equivalent Response Strategy for Sensing Total Biothiols in Human Serums and Living Cells Using a Hemicyanine-Based Self-Immolative Probe. Analytical Chemistry,2024, 96, 1009-1018.

4. Yang Xiao, Panpan Wang, Qian Wang, Nana Ma, Suling Feng, Guisheng Zhang*, Yi–Jun Gong*. A steric control specific probe for visualizing drug induced fluctuations of enzymatic H2S generation in living cells. Sensors & Actuators: B. Chemical, 2023, 396, 134515.

5. Yi- Jun Gong*, Dan- Dan Feng, Yi- Pin Zhang, Wei- Ning Liu, Suling Feng*, Guisheng Zhang*. Optimized self-immolative near-infrared probe based on hemicyanine for highly specific monitoring thiophenols in living systems. Talanta, 2021, 224, 121785.

6. Yi- Jun Gong*, Dan- Dan Feng, Wei- Ning Liu, Jing- Kun Fang*, Suling Feng*. A self-immolative near-infrared probe based on hemi-benzothiazolecyanine for visualizing hydrogen peroxide in living cells and mice. Dyes and Pigments, 2021, 186, 108954.

7. Yi-Jun Gong*, Wei-Zhen Xu, Yi-Pin Zhang, Dan-Dan Feng, Suling Feng, Guisheng Zhang*. A novel weak acid activated probe for highly selective monitoring selenocysteine in living cells. Talanta, 2020, 219, 121287.

8. Yi-Jun Gong*, Meng-Ke Lv, Ming-Lu Zhang, Zhen-Zhen Kong, Guo-Jiang Mao*. A novel two-photon fluorescent probe with long-wavelength emission for monitoring HClO in living cells and tissues. Talanta, 2019, 192, 128–134.

9.Yi-Jun Gong*, Zhen-Zhen Kong, Ming-Lu Zhang, Meng-Ke Lv, Guisheng Zhang. A structure optimized fluorescent probe for highly sensitive monitoring drug induced lysosomal pH value changes. Talanta, 2019, 203, 1–8.

10. Yi-Jun Gong*, Ming-Lu Zhang, Bing-Xin Wang, Qing Lv, Ying Wang, Wenpei Dong. A smart approach toward rhodamine spiro-ring derivatives sensing platform for lysosome-targetable imaging applications. Sensors & Actuators: B. Chemical, 2019, 283, 239–246.

11. Yi-Jun Gong, Xiao-Bing Zhang*, Guo-Jiang Mao, Li Su, Hong-Min Meng, Weihong Tan, Suling Feng, Guisheng Zhang*. A Unique Approach toward Near-Infrared Fluorescent Probes for Bioimaging with Remarkably Enhanced Contrast. Chemical Science, 2016, 7, 2275–2285.

12. Yi-Jun Gong, Xiao-Bing Zhang*, Cui-Cui Zhang, Ai-Li Luo, Ting Fu, Weihong Tan, Guo-Li Shen and Ru-Qin Yu. Through Bond Energy Transfer: A Convenient and Universal Strategy toward Efficient Ratiometric Fluorescent Probe for Bioimaging Applications. Analytical Chemistry, 2012, 84, 10777-10784.

13. Yi-Jun Gong, Xiao-Bing Zhang*, Zhuo Chen, Yuan Yuan, Zhen Jin, Lei Mei, Jing Zhang, Weihong Tan, Guo-Li Shen and Ru-Qin Yu*. An efficient rhodamine thiospirolactam-based fluorescent probe for detection of Hg²⁺ in aqueous samples. Analyst, 2012, 137, 932-938.

14. Yuanyuan Yue*, Qiao Dong, Yajie Zhang, Yangyang Sun, Yijun Gong*. A highly selective "turn-on" fluorescent chemosensor baseed on 8-aminoquinoline for detection of Zn2+. Analytical Methods, 2015, 7, 5661-5666.

15. Ai-Li Luo, Yi-Jun Gong*, Yuan Yuan, Jing Zhang, Cui-Cui Zhang, Xiao-Bing Zhang*, Weihong Tan. A Simple and pH-independent and Ultrasensitive Fluorescent Probe for the rapid detection of Hg²⁺. Talanta, 2013, 117, 326-332.

16. Cui-Cui Zhang, Yi-Jun Gong*, Yuan Yuan, Ai-Li Luo, Weijun Zhang, Jing Zhang, Xiao-Bing Zhang*, Weihong Tan. An Efficient Ratiometric Fluorescent Excimer Probe for Hypochlorite based on a Cofacial Xanthene-bridged Bispyrene. Analytical Methods, 2014, 6, 609-614.

17. Zhen Jin, De-Xun Xie, Xiao-Bing Zhang*, Yi-Jun Gong, Weihong Tan*. Bifunctional Fluoroionphore-Ionic Liquid Hybrid for Toxic Heavy Metal Ions: Improving Its Performance via the Synergistic Extraction Strategy. Analytical Chemistry, 2012, 84(10), 4253-4257.

18. Zhi-Xiang Han, Xiao-Bing Zhang, Zhuo Li, Yi-Jun Gong, Xiang-Yang Wu, Zhen Jin, Chun-Mei He, Li-Xin Jian, Jing Zhang, Guo-Li Shen and Ru-Qin Yu. Efficient Fluorescence Resonance Energy Transfer-Based Ratiometric Fluorescent Cellular Imaging Probe for Zn²⁺ Using a Rhodamine Spirolactam as a Trigger. Analytical Chemistry, 2010, 82(8): 3108-3113.

19. Zhen Jin, Xiao-Bing Zhang, De-Xun Xie, Yi-Jun Gong, Jing Zhang, Xin Chen, Guo-Li Shen and Ru-Qin Yu. Clicking Fluoroionophores onto Mesoporous Silicas: A Universal Strategy toward Efficient Fluorescent Surface Sensors for Metal Ions. Analytical Chemistry, 2010, 82(15), 6343-6346. (IF=5.828)

20. 张晓兵*，龚毅君，苏莉，毛国江。基于罗丹明螺环衍生物的荧光探针研究进展。南京师大学报（自然科学版），2015，38，2，1-16.