2006年，山东大学动物科学专业本科毕业。2011年，山东大学动物学专业博士毕业，同年入职河南师范大学。主持完成了国家自然科学基金青年基金和面上项目，河南省自然科学基金，河南省基础与前沿项目，河南省科技攻关项目等。以第一作者或者通讯作者发表SCI论文17篇。

   主要从事水产动物先天免疫系统的研究。主要研究内容包括模式识别受体如C型凝集素的功能，Toll样受体对细菌和病毒的识别和激活免疫的方式，血细胞吞噬细菌或病毒的机制，以及抗菌效应分子的活性等。

中国水产学会会员、中国动物学会会员、中国生化与分子生物学学会会员。

主持：

1. 螯虾甘露糖受体抗白斑综合征病毒研究，编号31873047，国家自然科学基金面上项目，2019.01-2020.12。

2. 螯虾含免疫球蛋白结构域C-型凝集素的免疫功能研究, 编号31301883，国家自然科学基金青年基金项目，2014.01-2016.12。

3. 河南省自然科学基金优秀青年科学基金，编号242300421115，2024.01-2025.12。

4. 河南省留学人员科研择优资助项目。

5. 中华绒螯蟹C-型凝集素参与白斑综合征病毒感染的机制研究，编号162300410166，河南省自然科学基金项目。2017.01-2018.12。

6. 螯虾致病菌鞭毛蛋白受体的抗菌作用和渔药应用，编号212102110380，河南省科技攻关项目。2021.01-2022.12。

7. 螯虾甘露糖受体抗白斑综合征病毒研究，编号20180554，河南师范大学优秀青年科学基金2018.01-2020.12。

8. 螯虾中含免疫球蛋白结构域的C型凝集素抗病作用研究，编号132300410140，河南省基础与前沿技术研究计划项目，2013.01-2015.12。

9. 中华绒螯蟹模式识别受体参与病原防御的分子机制研究，编号12A180018，河南省教育厅科学技术研究重点项目，2012.01-2014.12。

参与：

1. 对虾抗病毒相关基因的功能与抗病毒机理分析，编号31130056，国家自然科学基金重点项目，2012.01-2016.12，参与。

2.生物乙醇生产菌株改良研究，编号082102220012，河南省科技厅，2008.01-2010.12，参与。

代表性论文：

1.Xia XH#, Liang N#, Ma XY, Qin L, Chang ZJ, Zhang XW*. Effect of dietary supplementation with Leuconostoc mesenteroides DH on the antimicrobial capacity and overall health of juvenile loach (Misgurnus anguillicaudatus).Aquaculture. 579: 740208. (2024).

2.Xia XH#, Guo WW#, Ma XY, Liang N, Duan XY, Zhang PH, Zhang Y, Chang ZJ, Zhang XW*. Reproductive toxicity and cross-generational effect of polyethylene microplastics in Paramisgurnus dabryanus. Chemosphere. 313: 137440.(2023).

3.Jin ZY, Shen ML, Wang LE, Wang C, Gao MM, Yu GY, Chang ZJ*, Zhang XW*.Antibacterial and immunoregulatory activity of an antimicrobial peptide hepcidin in loach (Misgurnus anguillicaudatus).  International Journal of Biological Macromolecules 242: 124833.(2023).

4.Zhang XW, Shen ML, Wang C, Gao MM, Wang LE, Jin ZY, Xia XH*.Impact of aluminum exposure on oxidative stress, intestinal changes and immuneresponses in red swamp crayfish (Procambarus clarkii). Science of theTotal Environment. 855: 158902 (2023).

5.Zhang XW, Jin ZY, Shen ML, Chang ZJ, Yu GY, Wang L, Xia XH*.Accumulation of polyethylene microplastics induces oxidative stress, microbiome dysbiosis and immunoregulation in crayfish. Fish & Shellfish Immunology.125:276-284(2022).

6.Xia XH, Liu GP, Wu XL, Cui SS, Yang CH, Du QY, Zhang XW*. Effects of Macleaya cordata extract on TLR20 and the proinflammatory cytokines in acute spleen injury of loach (Misgurnus anguillicaudatus) against Aeromonas hydrophila infection. Aquaculture.544, 737105. (2021)

7.Zhang XW, Han KK, Yang CH, Xia XH, Ren Q, Zhang HW. Astomach-specific lectin plays a crucial role in the innate immunity of redswamp crayfish, Procambarus clarkia. Fish & Shellfish Immunology.103:285-292(2020).

8.Zhang XW, Yang CH, Xia XH, Pan XT, Jin ZY, Yu H, Zhang HW. Atriple WAP domain containing protein acts in antibacterial immunity of weatherloach, Misgurnus anguillicaudatus. Fish & Shellfish Immunology.103,277-284 (2020).

9.Zhang XW, Yang CH, Zhang HQ, Pan XT, Jin ZY, Zhang HW, XiaXH. A C-type lectin with antibacterial activity in weather loach, Misgurnus anguillicaudatus. Journal of Fish Diseases. (2020).

10.Zhang XW*,Wang Y, Wang XW, Wang L, Mu Y, Wang JX*.A C-type lectin with an immunoglobulin-like domain promotes phagocytosis of hemocytes in crayfish Procambarus clarkii.Scientific Reports. 6, 29924. (2016).

11.Zhang XW,Wang XW,Huang Y,Hui KM, Shi YR,Wang W*, Ren Q*. Cloning and characterization of two different ficolins from the giant freshwater prawn Macrobrachium rosenbergii.Developmentaland Comparative Immunology. 44(2), 359-69 (2014).

12.Zhang XW,Xu WT, Wang XW, Mu Y, Zhao XF, Yu XQ, Wang JX. A novel C-type lectin with twoCRD domains from Chinese shrimp Fenneropenaeus chinensis functions as a pattern recognition protein. Molecular Immunology.46(8-9), 1626-37 (2009).

13.Zhang XW,Wang XW, Sun C, Zhao XF, Wang JX. C-type lectin (Pc-Lec1) from freshwater crayfish Procambarus clarkii and itsfunction in hemocyte encapsulation. Archivesof Insect Biochemistry and Physiology 76 (3), 168-84 (2011).

14.Pan XT, Li TT, Yang CH, Ren Q, Zhang XW*.A toll receptor is involved in antibacterial defense in the oriental riverprawn, Macrobrachium nipponense. Fish & Shellfish Immunology.92, 583-589 (2019).

15.Zhang XW,Man X, Huang X, Wang Y, Song QS, Hui KM*,Zhang HW*. Identification of a C-type lectin possessing both antibacterial and antiviral activities from redswamp crayfish. Fish & Shellfish Immunology.77, 22-30 (2018).

16.Li TT, Ding ZF, Pan XT, Ma FT, Han KK, Wu L, Zhao LL, Ren Q∗, Zhang XW*. Characterization of an immune deficiency (IMD) homologfrom the oriental river prawn, Macrobrachium nipponense. Fish & Shellfish Immunology.83, 115-122 (2018).

17.Man X, Pan XT, Zhang HW, Wang Y, Li XC*,Zhang XW*. A mannose receptor is involved in the anti-Vibrio defense of redswamp crayfish. Fish & Shellfish Immunology.82, 258-266 (2018).