张春艳，博士，讲师。2018年12月获新疆大学动物学博士学位，2019年2月就职于河南师范大学生命科学学院生物工程系。主持河南省重点研发与推广专项（科技攻关）、河南省高等学校重点科研项目计划、河南师范大学培育基金青年项目、河南师范大学博士科研启动基金等，参与2项国家自然科学基金项目的研究工作，以第一作者或通讯作者在iScience, International Journal of Molecular Sciences, BMCGenomics, Cellular Signalling, Artif Cells Nanomed Biotechnol等SCI期刊上发表论文11篇。

肝再生和肝脏疾病中分子调控机制研究

1.miNRAs在肝再生和肝病中的作用及调控机制

2.锌结合蛋白在肝再生和肝病中的作用及调控机制

3.线粒体和自噬在肝再生和肝病中作用机制

无

1.河南省重点研发与推广专项(科技攻关)，基于miR-125a-5p 激动剂治疗肝纤维化药物靶点的筛选和应用, 2022/01 -2023/12，主持

2. 河南师范大学国家级科研项目培育基金（理科），miR-125a-5p通过自噬调节肝再中肝细胞增殖的作用机制（20210390），2021/05 -2023/12，主持

3. 河南省高等学校重点科研项目计划，miR-125a-5p通过自噬途径调控肝细胞增殖的作用机制（20A180014），2020/01-2021/12，主持

4. 国家自然科学基金联合基金，肝脏间皮干细胞的起源及其在肝再生中的作用研究（U1704182），2018/01-2020/12，参与

5. 国家自然科学基金青年基金项目，一个大鼠肝再生相关的新lncRNA（rLALR1）调节肝细胞增殖的作用及机理研究（31601038），2017/01-2019/12，参与

代表性论文：

1. Chunyan Zhang*, Caifang Sun, Yabin Zhao, Bingyu Ye, GuoYing Yu,*.Signaling pathways of liver regeneration: Biological mechanisms and implications. iScience.2023;27(1):108683.

2. Chunyan Zhang, YabinZhao, QiwenWang, Jianru Qin, Bingyu Ye, Cunshuan Xu, Guoying Yu*. Overexpression of miR-125a-5p Inhibits Hepatocyte Proliferation through the STAT3 RegulationIn Vivo and In Vitro, Int J Mol Sci, 2022, 23 (15): 8661.

3. Chunyan Zhang,Caifang Sun, Yabin Zhao, Qiwen Wang, Jianlin Guo, Bingyu Ye, Guoying Yu*;Overview of MicroRNAs as Diagnostic and Prognostic Biomarkers for High-Incidence Cancers in 2021, Int J Mol Sci, 2022 ,23(19):11389

4. Chunyan Zhang,Yabin Zhao, Mengli Yu, Jianru Qin, Bingyu Ye, Qiwen Wang*. Mitochondrial Dysfunction and Chronic Liver Disease, Curr Issues Mol Biol, 2022, 44(7):3156-3165.

5. Bingyu Ye#, WenlongShen#, Chunyan Zhang#, Mengli Yu, Xinru Ding, Man Yin, Yahao Wang,Xinjie Guo, Ge Bai, Kailin Lin, Shu Shi, Ping Li, Yan Zhang, Guoying Yu*, ZhihuZhao*. The role of ZNF143 overexpression in rat liver cell proliferation. BMC Genomics, 2022, 23: 483.

6. Qiwen Wang, Weixia Liu,Gaopeng Liu, Pan Li, Xueqiang Guo, Chunyan Zhang*. AMPK-mTOR-ULK1-mediated autophagy protects carbon tetrachloride -induced acute hepatic failure by inhibiting p21 in rats.J Toxicol Pathol. 2021;34(1): 73–82.

7. Chunyan Zhang, Bingyu Ye, Jiaojiao Wei, Qiwen Wang, Cunshuan Xu, Guoying Yu. MiR-199a-5pregulates rat liver regeneration and hepatocyte proliferation by targeting TNF-α/TNFR1/TRADD/CASPASE8/CASPASE3 signalling pathway.Artif Cells Nanomed Biotechnol. 2019; 47(1):4110-4118.

8. Qiwen Wang#, BingyuYe#, Ping Wang, Fenjie Yao, Chunyan Zhang*, Guoying Yu*. Overview of microRNA-199a regulationin cancer. Cancer Management and Research, 2019,11:10327-12335.

9. Chunyan Zhang,Cuifang Chang, Hang Gao, Qiwen Wang, Fuchun Zhang, Cunshuan Xu. MiR-429 regulates rat liver regeneration and hepatocyte proliferation by targeting JUN/MYC/BCL2/CCND1 signaling pathway. Cell Signal. 2018; 50 :80-89.

10. Chunyan Zhang, Cuifang Chang, Weiming Zhao, Hang Gao, Qiwen Wang, Deming Li, Fuchun Zhang, Shifu Zhang, Cunshuan Xu. The novel protein C9orf116 promotes rat liver cellline BRL-3A proliferation. PLoS One. 2017; 12(7):e0180607.

11. Chunyan Zhang, Cuifang Chang, Deming Li, Fuchun Zhang, Cunshuan Xu. The novel protein C3orf43 accelerates hepatocyte proliferation. Cell Mol Biol Lett. 2017; 22:21.