沈国民，博士，河南科技大学副教授，河南省医学会遗传医学分会青年委员会委员、洛阳市医学会血液专科学会副主任委员。教育经历：1998.09-2002.06河南师范大学本科；2002.09-2005.07河南师范大学硕士研究生；2008.09- 2011.08北京协和医学院博士研究生。目前主要研究维生素K代谢相关酶的结构与功能，靶向维生素K循环的新型抗凝药的研发，维生素K代谢与血友病和易栓症等。

主要成就：在Science,Nature Structural & Molecular Biology, Nature Communication, EMBOJ, Journal of Thrombosis and Hemostasis，Journalof Biological Chemistry等高水平SCI期刊发表论文21篇，主持国家自然科学基金3项，其中青年基金1项，面上项目2项；主持河南省重点科技攻关项目1项（国际科技合作）。目前申请国家发明专利7项，获批专利2项，进入实审4项。河南省血栓与止血国际联合实验室主任。先后获得河南省优秀教师，河南省高等学校青年骨干教师，洛阳市优秀教师，洛阳市第九批优秀专家等荣誉称号。

代表成果：

1.Guomin Shen^#,Weidong Cui^#,Hao Zhang, Fengbo Zhou, Wei Huang, Yihu Yang, Qian Liu, Greg Bowman,Evan Sadler, Michael Gross, Weikai Li. Warfarin traps human vitamin Kepoxide reductase in an intermediate state during electron transfer.Nature Structural & Molecular Biology, 2017 Jan;24(1):69-76.（Featuredin News and Views ）

2.Shixuan Liu, Shuang Li, Guomin Shen, Narayanasami Sukumar, Andrzej M.Krezel, Weikai Li^*.Structural basis of antagonizing the vitamin K catalytic cycle foranticoagulation. Science. 2020, DOI: 10.1126/science.abc5667.

3.Shen, Guomin^*;Cui, Weidong; Cao, Qing; Gao, Meng; Liu, Hongli; Su, Gaigai; Gross,Michael L; Li, Weikai^*.The catalytic mechanism of vitamin K epoxide reduction in a cellularenvironment. Journal of Biological Chemisry, 2021, 296(1): 100145.

4.Gao, Wenwen^#;Xu, Yaqi^#;Liu, Hongli^#;Gao, Meng; Cao, Qing; Wang, Yiyi; Cui, Longteng; Huang, Rong; Shen,Yan; Li, Sanqiang; Yang, Haiping; Chen, Yixiang; Li, Chaokun; Yu,Haichuan; Li, Weikai^*;Shen, Guomin^*.Characterization of missense mutations in the signal peptide andpropeptide of FIX in hemophilia B by a cell-based assay. BloodAdvances, 2020, 4(15): 3659-3667.

5.Guomin Shen, Shuang Li, Weidong Cui, Shixuan Liu, Qian Liu, YihuYang, Michael Gross, and Weikai Li^*.Stabilization of warfarin-binding pocket of VKORC1 and VKORL1 by aperipheral region determines their different sensitivity to warfarininhibition. Journal of Thrombosis and Haemostasis. 2018,16(6):1164-1175.  Cover Story