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范学森
博士，教授，博士生导师，河南师范大学特聘教授，河南省优秀青年科技专家，河南省青年科技奖及河南省杰出青年基金获得者，有机化学重点学科学术带头人，有机化学教研室主任。   

电话：0373-3329261
 E-mail: xuesen.fan@henannu.edu.cn

课题组网站: https://www.htu.edu.cn/fxsjsktz/main.htm

 
 

学习经历

 1987.09-1991.06 河南师范大学，化学专业本科
  1991.09-1994.06 河南师范大学，有机化学专业硕士，师从张深松教授
  2000.02-2003.03 浙江大学，有机化学专业博士，师从张永敏教授


工作经历
   1994.09-2003.12 河南师范大学，助教、讲师、副教授

   2004.01-2006.12 美国北亚里桑那大学、马里兰大学，博士后研究员

   2010.04-2010.05 埃及亚历山大大学，访问学者

   2012.07-2012.08 法国巴黎大学，访问学者

   2007.01 至今 河南师范大学，副教授、教授、校特聘教授，博士生导师


主讲课程：
    金属有机化学；有机合成化学；有机与药物化学专论

研究领域和兴趣：

   1. 嘧啶核苷衍生物作为潜在抗病毒药物的设计、合成及生物活性研究
     2. 有机合成新方法研究 

 

近年来主持的主要科研项目: 

  1. 国家自然科学基金项目（20772025）：5-取代嘧啶碳环核苷的合成及生物活性研究。 
   2. 国家自然科学基金项目（20972042）：核苷/非核苷HIV逆转录酶抑制剂杂化体的合成及生物活性研究。
   3. 国家自然科学基金国际交流项目（20911140238）：新型核苷类似物的合成及生物活性研究     

   4. 河南省杰出青年基金（104100510019）：核苷类似物的合成及抗HIV活性研究。

   5. 国家自然科学基金项目（21272058）：基于联烯多样反应性能的核苷衍生物的合成、生物活性和荧光性能研究。

 

发表论文

49. He, Y.; Zhang, X. Y.; Shen, N. N.;Fan, X. S.

Tunable Synthesis of 3-Acyl-2-naphthols and 3-Substituted Isocoumarins via Jones Reagent Promoted Cascade Reactions of 2-(4-Hydroxy-but-1-ynyl)benzaldehydes.

J. Org. Chem.2013, 78(20), 10178-10191.

48. He, Y.; Zhang, X. Y.; Shen, N. N.; Fan, X. S.

Synthesis of α-fluoroketones and α-fluoroenones in aqueous media.

J. Fluorine. Chem.2013, 156(12), 9-14. 

47. He, Y.; Shen, N. N.; Fan, X. S.; Zhang.X. Y.

Synthesis of β-fluoroenones and their reductive rearrangement in aqueous media.

Tetrahedron. 2013, 69(41), 8818-8823.

46. Guo, S. H.; Wang, J. L.; Fan, X. S.; Zhang, X. Y.; Guo, D. Q.

Synthesis of pyrazolo[1,5-c]quinazoline derivatives through copper-catalyzed tandem reaction of 5-(2-bromoaryl)-1H-pyrazoles with carbonyl compounds and aqueous ammonia.

J. Org. Chem.2013, 78(7), 3262-3270.

45. Wang, Q.; Xu, Z. Q.; Fan, X. S. 

Selective synthesis of oxygen-containing heterocycles via tandem reactions of 1,2-allenic ketones with ethyl 4-chloroacetoacetate.

RSC Adv. 2013, 3(13), 4156-4160.

44. He, Y.; Zhang, X. Y.; Cui, L. Y.; Fan, X. S.

Iodine-initiated domino reaction of hepta-1,2-dien-6-yn-4-ols and brønsted acid promoted cyclization of hepta-1,2,6-trien-4-ols leading to functionalized benzenes.

Chem. Asian J. 2013, 8(4), 717-722.

43. He, Y.; Zhang, X. Y.; Cui, L. Y.; Wang, J. J; Fan, X. S.

Catalyst-free synthesis of diversely substituted 6H-benzo[c]chromenes and 6H-benzo[c]chromen-6-ones in aqueous media under MWI.

Green Chem. 2012, 14(12), 3429-3435.   

42. Cui, LY; He, Y; Fan, X. S.

A sustainable synthesis of 2-benzoxazyl and 2-benzothiazyl Ketones from alkynyl bromides and 2-amino(thio)phenols promoted by a recyclable catalytic system.

Chin. J. Chem. 2012, 30(4), 992-996. 

41. Guo, S. H.; Wang, J. L.; Guo, D. Q.; Zhang, X. Y.; Fan, X. S.

Highly regioselective and practical synthesis of 1-acyl-5-hydroxypyrazolines and 1-acyl pyrazoles from 1,2-allenic ketones and hydrazides.

Tetrahedron, 2012, 68, 7768-7774.   

40. Guo, S. H.; Wang, J. L.; Guo, D. Q.; Zhang, X. Y.; Fan, X. S.

Synthesis of 3,5-disubstituted pyrazoles via cyclocondensation of 1,2-allenic ketones with hydrazines: application to the synthesis of 5-(5-methyl-pyrazol-3-yl)-2'-deoxycytidine.

RSC Adv. 2012, 2, 3772-3777.   

39.  Xu, H. Y.; Zhang, X. Y.; He, Y.; Guo, S. H.; Fan, X. S.

Tandem reaction of 3-hydroxyhexa-4,5-allenic esters: a novel access to diversely substituted 2H-pyran-2-ones and indenes.

Chem. Commun. 2012, 48(25), 3121-3123.
              38. Fan, X. S.; He, Y.; Cui, L. Y.; Guo, S. H.; Wang, J. J.; Zhang, X. Y.

Tandem reactions leading to benzo[c]chromen-6-ones and 3-substituted isocoumarins.

Eur. J. Org. Chem. 2012, (4), 673-677.
              37. Amer, A.; Senior, S.; Fan, X. S.

5-Substituted pyrimidine L-2′-deoxyribonucleosides: synthetic, quantum chemical, and NMR studies.

Nucleos. Nucleot. Nucl. 2012, 31(1), 42-54.
              36. Fan, X. S.; He, Y.; Cui, L. Y.; Zhang, X. Y.; Wang, J. J.

Tandem reaction of 1,2-allenic ketone with α-halo ketone or α-halo ester in water: an efficient and sustainable synthesis of 1,3,4'-tricarbonyl compounds.

Green Chem. 2011, 13(11), 3218-3223.
              35. Zhang, X. Y.; Jia, X. F.; Fang, L. L.; Liu, N.; Wang, J. J.; Fan, X. S.

Tandem reactions of 1,2-allenic ketones leading to substituted benzenes and α,β-unsaturated nitriles.

Org. Lett. 2011, 13(19), 5024-5027.
              34. Fan, X. S.; Zhang, X. Y.; Wang, J. J.

Recent progress in the green and efficient synthesis of biologically privileged scaffolds in ionic liquids.

Curr. Org. Synth. 2011, 8, 721-751.
              33. Fan, X. S.; He, Y.; Zhang, X. Y.; Guo, S. H.; Wang, Y. Y.

Synthesis of heteroaryl ketones via tandem reaction of 1,1-dibromoethenes.

Tetrahedron 2011, 67,  6369-6374.
              32. Fan, X. S.; Wang, Y. Y.; Qu, Y. Y.; Xu, H. Y.; He, Y.; Zhang, X. Y.; Wang, J. J.

Tandem reactions leading to bicyclic pyrimidine nucleosides and benzopyran-4-ones.

J. Org. Chem. 2011, 76(3), 982-985.
              31. Zhang, X. Y.; Jia, X. F.; Wang, J. J.; Fan, X. S.

An economically and environmentally sustainable synthesis of 2-aminobenzothiazoles and 2-aminobenzoxazoles promoted by water.

Green Chem. 2011, 13(2), 413-418.
              30. Xuesen Fan, Yan He, Yangyang Wang, Xinying Zhang, Jianji Wang.

A novel and practical synthesis of 2-benzoyl benzothiazoles and 2-benzylbenzothiazoles.

Tetrahedron Lett. 2011, 52, 899-902.
              29. Zhang, X. Y.; Li, D. F.; Jia, X. F.; Wang, J. J.; Fan, X. S.

CuI/[bmim]OAc in [bmim]PF6: a highly efficient and readily recyclable catalytic system for the synthesis of 2,3-disubstituted benzo[b]furans.

Catal. Commun. 2011, 12, 839-843.
              28. Fan, X. S.; Qu. Y. Y.; Wang, Y. Y.; Zhang, X. Y.; Wang, J. J.

Ru(III)-catalyzed oxidation of homopropargyl alcohols in ionic liquid: an efficient and green route to 1,2-allenic ketones.

Tetrahedron Lett. 2010, 51, 2123-2126.
              27. Fan, X. S.; Wang, Y. Y.; He, Y.; Zhang, X. Y.; Wang, J. J.

Ru(III)-catalyzed oxidative reaction in ionic liquid: an efficient and practical route to 2-substituted benzothiazoles and their hybrids with pyrimidine nucleoside.

Tetrahedron Lett. 2010, 51, 3493-3496.
              26. Zhang, X. Y.; Li, D. F.; Fan, X. S.; Wang, X.; Li, X. Y.; Qu, G. R.; Wang, J. J. 

Ionic liquid-promoted multi-component reaction: novel and efficient preparation of pyrazolo[3,4-b]pyridineone, pyrazolo[3,4-b]quinolinone and their hybrids with pyrimidine nucleoside.

Mol. Divers. 2010, 14, 159-167.
              25. Fan, X. S.*; Feng, D.; Qu, Y. Y.; Zhang, X. Y.; Wang, J. J.; Loiseau, P. M.; Andrei, G.; Snoeck, R.; Clercq, E. D.

Practical and efficient synthesis of pyrano [3,2-c]pyridone, pyrano[4,3-b]pyran and their hybrids with nucleoside as potential antiviral and antileishmanial agents.

Bioorg. Med. Chem. Lett. 2010, 20, 809-813.
              24. Zhang, X. Y.; Li, X. Y.; Li, D. F.; Qu, G. R.; Wang, J. J.; Loiseau, P. M.; Fan, X. S.

Ionic liquid mediated and promoted eco-friendly preparation of thiazolidinone and pyrimidine nucleoside-thiazolidinone hybrids and their antiparasitic activities.

Bioorg. Med. Chem. Lett. 2009, 19, 6280-6283.
              23. Zhang, X. Y.; Li, X. Y.; Fan, X. S.; Wang, X.; Wang, J. J.; Qu, G. R.

Controllable synthesis of pyrazolo[3,4-b]pyridines or substituted malononitrile derivatives through multi-component reactions in ionic liquid.

Aust. J. Chem. 2009, 62, 382-388.
              22. Zhang, X. Y.; Li, X. Y.; Fan, X. S.*; Wang, X.; Li, D. F.; Qu, G. R.; Wang, J. J.

Ionic liquid promoted preparation of 4H-thiopyran and pyrimidine nucleoside-thiopyran hybrids through one-pot multi-component reaction of thioamide.

Mol. Divers. 2009, 13, 57-61.
               21. Fan, X. S.; Wang, X.; Zhang, X. Y.; Li, X. Y.; Qu, G. R.

A simple and efficient preparation of pyrazolo[3,4-b]pyridine derivatives through an unexpected reaction of cyanothioacetamide under microwave irradiation.

Heteroatom Chem. 2008,19, 694-699.
              20. Fan, X. S.;Zhang, X. Y.; Bories, C.; Loiseau, P. M.; Torrence, P. F.

The Ugi reaction in generation of new nucleosides as potential antiviral and antileishmanial agents.

Bioorg. Chem. 2007, 35, 121-136.
              19. Fan, X. S.; Li, Y. Z.;Zhang, X. Y.; Qu, G. R.; Wang, J. J.

An efficient and green preparation of 9-arylacridine-1,8-dione derivatives.

Heteroatom Chem. 2007, 18, 786-790.
              18. Hu, X. Y.; Fan, X. S.; Zhang, X. Y.; Li, Y. Z.; Qu, G. R.

Solvent-free synthesis of 5-oxo-5,6,7,8-tetrahydro-4H-benzo[b]pyran derivatives under microwave irradiation.

Can. J. Chem. 2006, 84,1054-1057.
              17. Fan, X. S.; Li, Y. Z.; Zhang, X. Y.; Hu, X. Y.; Wang, J. J.

A novel and green version of the Passerini reaction in an ionic liquid ([bmim][BF4]).

Can. J. Chem. 2006, 84, 794-799.
              16. Fan, X. S.; Zhang, X. Y.; Zhou, L. H.; Keith, K. A.; Kern, E. R.; Torrence, P. F.

A pyrimidine-pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity. Bioorg. Med. Chem. Lett. 2006, 16, 3224-3228.
              15. Fan, X. S.; Zhang, X. Y.; Zhou, L. H.; Keith, K. A.; Prichard, M. N.; Kern, E. R.; Torrence, P. F.

5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activity.

J. Med. Chem. 2006, 49, 3377-3382.
              14. Fan, X. S.; Zhang, X. Y.; Zhou, L. H.; Keith, K. A.; Prichard, M. N.; Kern, E. R.; Torrence, P. F.

Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure.

J. Med. Chem. 2006, 49, 4052-4054.
              13. Fan, X. S.; Zhang, X. Y.; Zhou, L. H.; Keith, K. A.; Kern, E. R.; Torrence, P. F. Assembling a smallpox biodefense by interrogating 5-substituted pyrimidine nucleoside chemical space.

Antiviral Res. 2006, 71, 201-205. 
12. Fan, X. S.;Hu, X. Y.; Zhang X. Y.; Wang, J. J.

InCl3·4H2O promoted green preparation of xanthenedione derivatives in ionic liquids.

Can. J. Chem. 2005, 83, 16.

11. Fan, X. S.;Hu, X. Y.; Zhang X. Y.; Wang, J. J.

Ionic liquids promoted Knoevenagel and Micheal reactions.

Aust. J. Chem. 2004, 57, 1067-1071.

10. Wang, J. J.; Fan, X. S.;Zhang X. Y.; Han, L. J.

Green preparation of quinoline derivatives through FeCl3·6H2O catalyzed Friedlander reaction in ionic liquids.

Can. J. Chem. 2004, 82(7), 1192-1196.

9. Fan, X. S.; Zhang, Y. M.

SmI2 Mediated synthesis of 2,3-disubstituted indole derivatives.

Tetrahedron. 2003, 59, 1917.

8. Zhang X. Y.; Fan, X. S.;Niu, H. Y.; Wang, J. J.

Ionic liquid as a recyclable medium for the green preparation of α,α’–bis(substituted benzylidene) cycloalkanones catalyzed by FeCl3·6H2O.

Green Chem. 2003, 5, 267.

7. Fan, X. S.;Zhang, Y. M.

SmI2-mediated synthesis of 2,4-diarylpyrroles from phenacyl azides.

Tetrahedron Lett. 2002, 43, 1863.

6. Fan, X. S.; Zhang, Y. M.

SmI2 mediated facile one-pot preparation of 2,4-diarylquinolines from 3-aryl-2,1-benzisoxazoles.

Tetrahedron Lett. 2002, 43, 7001.

5. Fan, X. S.; Zhang, Y. M.

Preparation of dihomoallylic secondary amines through samarium mediated allylation of oximes.

Tetrahedron Lett. 2002, 43, 5475.

4. Fan, X. S.; Zhang, Y. M.

Application of manganese reagents in organic synthesis.

Chin. J. Org. Chem. 2001, 21, 564.

3. Fan, X. S.; Zhang, Y. M.

Reductive cyclodimerization of α,β-unsaturated ketones promoted by AlCl3/Sm system: a facile synthesis of 2-aroyl-1,3,4-triaryl cyclopentanol derivatives.

Chin. J. Chem. 2001, 19, 616.

2. Fan, X. S.; Zhang, Y. M.

Stereoselective synthesis of (E)-cinnamates with Sm/HOAc.

Chin. J. Chem. 2001, 19, 914.

1. Fan, X. S.; Zhang, Q. Z.; Zhang, X. Y.; Zhang, S. S.

Studies on the aborption of NO2 by polyethylene glycol and the oxidizing properties of the resulting absorbent product.

Chin. Chem. Lett. 1997, 8, 747.

 

专利申请

  

11. 郭胜海，范学森，王继亮，张新迎，郭东强. 一种吡唑并[1,5-c]喹唑啉类化合物的合成方法. 发明专利, 申请号: 201310075920.5.

10. 范学森，郭胜海，王继亮，张新迎，王强，郭东强. 一种5,6-二氢吡唑并[1,5-c]喹唑啉类化合物的合成方法. 发明专利, 申请号: 201310076089.5.

9. 王强, 范学森, 郭胜海, 杨磊, 张新迎. 一种合成多取代苯并[1,3]间二氧杂环戊烷类化合物的方法. 发明专利, 申请号: 201310025394.1.

8. 王强, 范学森, 徐周庆, 郭胜海, 张新迎. 一种多取代氧杂环庚三烯-3(2H)-酮类化合物的合成方法. 发明专利, 申请号:201310025506.3.

7. 范学森, 张新迎, 冯东, 王国利, 曲莹莹, 王洋洋, 郭胜海. 5-甲酰基嘧啶碳环核苷及其制备方法. 发明专利, 申请号: 201110463012.4.
              6. 范学森, 张新迎, 郭胜海, 李晓严, 王洋洋, 李东方. 新型5-取代嘧啶核苷衍生物及制备方法. 发明专利, 申请号: 201110463013.9.
              5. 范学森, 张新迎, 冯东, 王国利, 王霞, 郭胜海, 何艳, 贾雪菲. 5-位缺电子烯基取代嘧啶碳环核苷及制备方法. 发明专利, 申请号: 201210026439.2.
              4. 范学森, 张建瑞, 张新迎, 何艳, 郭胜海. 一种合成5-((E)-2-溴乙烯基)-2'-脱氧尿嘧啶核苷（溴呋啶）的方法. 发明专利, 申请号: 201110359183.2.
              3. 范学森, 张新迎, 李晓严, 王洋洋, 徐海云, 郭胜海, 何艳. 具有抗HIV活性的5-取代嘧啶核苷-噻唑啉酮杂化体及其制备方法. 发明专利, 申请号: 201210026427.X.
              2. 张新迎, 范学森, 郭胜海, 何艳, 贾雪菲, 崔良艳, 方亮亮. 5-位氢化吡喃基取代嘧啶碳环核苷及制备方法. 发明专利, 申请号: 201210026464.0.

1. 张新迎，范学森，蒋盼盼，郭胜海.一种合成5-氰基嘧啶核苷衍生物的方法. 发明专利，申请号：201110359194.0.












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