| 王海霞，博士，教授 |
1.教育经历 2007/09-2010/06，山东大学，化学化工学院，无机化学专业，博士，导师：李希友 2000/09-2003/06，河南师范大学，化学化工学院，无机化学专业，硕士，导师：蒋凯 1996/09-2000/06，河南师范大学，化学化工学院，精细化工专业，学士 2.科研与学术工作经历 2022/04-----至今，河南师范大学，化学化工学院，教 授 2012/03-2022/03，河南师范大学，化学化工学院，副教授 2006/07-2012/02，河南师范大学，化学化工学院，讲 师 2003/07-2006/06，河南师范大学，化学化工学院，助 教 3.近期主要科研成果 3.1 主持或参加科研项目情况 (1) 国家自然科学基金-河南联合基金培育项目，U1604182，手性三元碳环核苷类化合物的设计合成及生物活性研究，2017/01-2019/12，46万元，结项，主持； (2) 河南省自然科学基金-面上科学基金项目，222300420474，手性诱导策略下通过[3+2]环加成合成手性五元杂环核苷类化合物，2022/01-2023/12，10万元，结项，主持； (3) 河南省教育厅科学技术研究重点项目，14B150031，嘌呤核苷类荧光探针的设计、合成和性质研究，2014/01-2015/12，河南省教育厅，结项，主持； (4) 973计划前期研究专项，2014CB560713，具有抗病毒活性的手性非环核苷类药物的新合成策略研究，2014/10-2016/08，65万元，科技部，结项，主要完成人； (5) 河南省教育厅教师教育课程改革研究项目，2016-JSJYZD-016，强素质重能力的卓越中学化学教师培养研究与实践（省级重点），3万元，河南省教育厅，2019年结项，主持。 3.2 发表的主要期刊论文 (20) Xing-Ping Zhang, Sai-Ya Lian, Hai-Xia Wang*, Ming-Sheng Xie*, Hai-Ming Guo*, Zn(II)-Catalyzed Asymmetric Transfer Hydrogenation of γ-Indolyl β,γ-Unsaturated α-Keto Amides and α-Keto Esters with Hantzsch Ester, Adv. Synth. Catal., 2025, 367, e202500158. (19) Ning Li, Wen-Jing Li, Xin-Yi Chen, Hai-Xia Wang*, Ming-Sheng Xie*, Hai-Ming Guo*, Cu(II)-Catalyzed Asymmetric All-Carbon-Based Diels–Alder Reaction of Conjugated Vinyl Azides: Synthesis of Chiral Fused and Spiro Cyclohexenes, Adv. Synth. Catal., 2025, 367, e202500089. (18) Hai-Xia Wang, Chun Yang, Bai-Yu Xue, Ming-Sheng Xie*, Yin Tian*, Cheng Peng, Hai-Ming Guo*, Design of C1-symmetric tridentate ligands for enantioselective dearomative [3+2] annulation of indoles with aminocyclopropanes, Nat. Commun., 2023, 14(1), 2270. (17) Hai-Xia Wang, Mi-Mi Zhang, Ming-Sheng Xie,* and Hai-Ming Guo*, Lewis Acid Catalyzed (3+2)-Cycloadditions of Chiral Pyrimidinyl-Substituted Cyclopropanes with Nitrosoarenes or Silyl Enol Ethers, Eur. J. Org. Chem.2022, 2022(25), e202200604. (16) Hai-Xia Wang, Zhi-Hao Li, Wan-Wan Li, Gui-Rong Qu, Qi-Liang Yang* and Hai-Ming Guo*, Electrochemically driven oxidative C–H/N–H cross-coupling reactions of cyclic sulfamidate imines with primary anilines and secondary amines, Green Chem., 2022, 24(21), 8377-8385. (15) Hai-xia Wang, Wen-Peng Li, Mi-Mi Zhang, Ming-Sheng Xie* Gui-Rong Qu, Hai-Ming Guo*, Synthesis of chiral pyrimidine-substituted diester D-A cyclopropanes via asymmetric cyclopropanation of phenyliodonium ylides, Chem. Commun., 2020, 56(78), 11649-11652. (14) Hai-Xia Wang, Wen-Peng Li, Chao Xia, Ming-Sheng Xie*, Gui-Rong Qu, Hai-Ming Guo*, Enantioselective synthesis of chiral carbocyclic pyrimidine nucleosides via asymmetric cyclopropanation, Tetrahedron Lett., 2019, 60(43), 151183. (13) Haixia Wang, Fangjuan Guan, Mingsheng Xie*, Guirong Qu, Haiming Guo*, Construction of All-Carbon Quaternary Stereocenters via Asymmetric Cyclopropanations: Synthesis of Chiral Carbocyclic Pyrimidine Nucleosides, Adv. Synth. Catal., 2018, 360, 2233-2238. (12) Haixia Wang, Lulu Yu, Mingsheng Xie, Jiang Wu, Guirong Qu, Kuiling Ding,* Haiming Guo*, Regio- and Enantioselective Allylic Amination of Aliphatic MBH Adducts with N-Heteroaromatics, Chem. Eur. J. 2018, 24(6), 1425-1430. (11) Jianping Li, Guofeng Zhao, Haixia Wang, Mingsheng Xie*, Guirong Qu, Haiming Guo*, Highly Enantioselective Synthesis of Chiral Cyclopropyl Nucleosides via Catalytic Asymmetric Intermolecular Cyclopropanation, Org. Lett., 2017, 19 (24), 6494-6497. (10) Lei Liang, Mingshen Xie, Haixia Wang, Hongying Niu, Guirong Qu, Haiming Guo*, Visible-Light-Mediated Monoselective Ortho C-H Arylation of 6-Arylpurine Nucleosides with Diazonium Salts, J. Org. Chem., 2017, 82 (11), 5966-5973. (9) Dongchao Wang, Haixia Wang, Erjun Hao, Xiaohan Jiang, Mingsheng Xie, Guirong Qu*, Haiming Guo*, Synthesis of 3,3-Disubstituted Oxindoles Containing a 3-(4-Aminobut-2-ynyl) Unit via Domino Heck-Sonogashira Reaction in Water, Adv. Synth. Catal., 2016, 358, 494-499. (8)Haixia Wang, Dandan Xi, Mingsheng Xie*, Huixuan Wang, Guirong Qu, Haiming Guo*, Nucleoside-Based Diarylethene Photoswitches: Synthesis and Photochromic Properties, ChemBioChem, 2016, 13, 1216-1220. (7) Shaohua Gao, Mingsheng Xie, Haixia Wang, Hongying Niu, Guirong Qu,* Haiming Guo*, Highly Selective Detection of Hg2+ ion by Push-Pull-Type Purine Nucleoside-Based Fluorescent Sensor, Tetrahedron, 2014, 70, 4929-4933. (6) Jianping Li, Huixuan Wang, Haixia Wang*, Mingsheng Xie, Guirong Qu, Hongying Niu, Haiming Guo*, Push-Pull-Type Purine Nucleoside-Based Fluorescent Sensors for the Selective Detection of Pd2+ in Aqueous Buffer, Eur. J. Org. Chem. 2014, 2225-2230. (5) Haixia Wang*, Yuehe Lang, Huixuan Wang, Jingjing Lou, Haiming Guo, Xiyou Li*, Perylene Diimide based “Turn-on” Fluorescence Sensor for Detection of Pd2+ in Mixed Aqueous Media, Tetrahedron 2014, 70, 1997-2002. (4) Haixia Wang, Lin Yang, Yu Zhou, Bing Zhao, Xiyou Li*, A Colorimetric Probe for Copper(II) Ion based on 4-Amino-1,8-Naphthalimide, Inorg. Chim. Acta 2012, 381,111-116. (3) Haixia Wang, Haixia Wu, Lin Xue, Yan Shi, Xiyou Li*, A Naphthalimide Fuorophore with Efficient Intramolecular PET and ICT Processes: Application in Molecular Logic, Org. Biomol. Chem. 2011, 9, 5436-5444. (2) Haixia Wang, Delou Wang, Qi Wang, Xiyou Li*, Christoph. A. Schalley*，Nickel(II) and Iron(III) Selective Off-On-Type Fluorescence Probes Based on Perylene Tetracarboxylic Diimide，Org. Biomol. Chem. 2010, 8, 1017-1026. (1) Xiyou Li, Haixia Wang, Haixia Wu, Phthalocyanines and Their Analogs Applied In Dye-Sensitized Solar Cell, Structure Bond, 2010, 135, 229-274. 3.3 授权专利 (1) 一种环加成合成手性异噁唑环及碳环核苷类似物的方法，发明人：王海霞，陈汉生，张蜜蜜，谢明胜，渠桂荣，郭海明，专利号ZL202210572077.0，授权公告日2023/9/29 (2) 不对称环丙烷化合成手性嘧啶取代双酯基环丙烷的方法，发明人：王海霞，张蜜蜜，李文朋，谢明胜，郭海明，渠桂荣，专利号ZL202010635935.2，授权公告日2021/8/27 (3) 一种通过迈克尔加成引发的不对称环丙化合成手性三元碳环核苷的方法，发明人：谢明胜，郭海明，赵国锋，李建平，王东超，王海霞，专利号ZL201710903922.7，授权公告日2019/10/18 (4) 一种合成手性非环和碳环核苷类似物的方法，发明人：郭海明，王海霞，谢明胜，于露露，渠桂荣，专利号ZL201710735418.0，授权公告日2019/7/9 (5) 一种不对称烯丙基氨化反应合成手性非环核苷类似物的方法，发明人：谢明胜，于露露，王海霞，郭海明，渠桂荣，专利号ZL201710735997.9，授权公告日2019/7/9 (6) 一种制备阿德福韦酯的方法，发明人：郭海明，李仁龙，王海霞，王东超，张倩，谢明胜，渠桂荣，专利号ZL201410745076. 7，授权公告日2016/8/24 (7) 一种合成含氟非环核苷类似物的方法，发明人：郭海明，韩瑞杰，谢明胜，王东超，王海霞，渠桂荣，专利号ZL201410753737. 0，授权公告日2016/5/18 (8) 8-环己基-2-氟阿糖腺苷、制备方法及其应用，发明人：郭海明，渠桂荣，夏然，王东超，谢明胜，王海霞，秦博文，专利号 ZL 201310428421. X, 授权公告日2015/5/27 4. 主要荣誉 2020 年 8 月，获河南省“文明教师” 2020 年 7 月，获河南省教科文卫体系统“优秀教师” 2017年6月，获“河南省高校优秀共产党员” 2013年8月，全省教育系统教学技能竞赛中荣获一等奖，并获“河南省教学标兵”荣誉称号 2014年6月，获“河南师范大学文明教师” 2019年、2017年、2016年多次荣获“河南师范大学优秀实习指导教师” |