添加虾青素延缓 CdTeQDs致肝损伤的机制初探

摘要：

碲化锅量子点(CdTe QDs)因其生物安全性与健康风险引起科学界的广泛关注。以昆明小鼠为研究对象探究铁死亡在虾青素(AST)减轻CdTe QDs诱导小鼠肝损伤中的作用及其可能的机制。结果显示，CdTe QDs在肝脏中积累并造成明显的组织病理学损伤，添加虾青素后肝组织的损伤明显缓解。此外，虾青素显著缓解CdTe QDs诱导的脂质过氧化水平增加。对铁死亡标志物Nrf2(核因子红细胞2相关因子2)、SLC7A11、FTH1、GPX4蛋白的表达水平、肝脏铁含量和线粒体结构进行检测和观察，发现虾青素降低铁死亡相关蛋白水平和肝脏铁含量，减轻线粒体损伤。另外，对铁死亡相关基因的表达进行检测，发现其变化趋势与蛋白水平一致。结果表明，虾青素可能通过激活Nrf2/SLC7A11/GPX4通路抑制铁死亡，缓解肝脏损伤。

Cadmium telluride quantum dots(CdTe QDs)have attracted wide spread attention from the scientific community due to their biosafety and health risks. The aim of this paper was to investigate the role of ferroptosis in the attenuation of CdTe QDs-induced liver injury in mice by astaxanthin(AST)and its possible mechanism. The results showed that CaTe QDs accumulated in the liver and caused obuious histopathological damage, which was significantly alleviated by the addition of astax-anthin, More over, astaxanthin significantly alleviated the increased levels of lipid peroxidation induced by CdTe QDs, The expression levels of ferroptosis markers Nrf2, SLC7A11, FTH1, GPX4 proteins, liver iron content and mitochondrial structure were examined and observed, and it was found that astaxanthin decreased ferroptosis-related protein levels and liver iron con-tent and attenuated mitochondrial damage. More over, the expression of ferroptosis-related genes was examined and the trend was found to be consistent with the protein levels. The above results suggest that astaxanthin may inhibit ferroptosis and allevi-ate liver injury by activating the Nrf2/SLC7A11/GPX4 pathway.

作者: 

陈建军，郭素琪

Chen Jianjun,Guo Suqi

机构地区：

河南师范大学生命科学学院

引用本文：

陈建军，郭素琪。添加虾青素延缓CdTe QDs致肝损伤的机制初探[J].河南师范大学学报(自然科学版).2026.54(2);110-116.(Chen Jianjun, Guo Suqi. A preliminary investigation on the mechanism of delaying liver injuryby CdTe QDs with the addition of astaxanthin[J].Journal of Henan Normal University (Natural Science Edition),2026,54(2) :110-116.DOI:10.16366/j.cnki.1000-2367.2023.03.09.0002.)

基金：

河南省科技发展计划项目

关键词：

虾青素；碲化镉量子点；铁死亡；肝损伤

astaxanthin; CdTe QDs; ferroptosis; liver injury

分类号：

Q955

添加虾青素延缓 CdTeQDs致肝损伤的机制初探.pdf