| 博士，教授，博士生导师 河南省高等学校化工与制药专业教学指导委员会副主任委员 河南省化工学会第一届教育工作委员会副主任委员 中国老年骨科学会基础学组专家委员会委员 |
教育经历：
1999/9-2002/7，北京大学，药物化学，博士，导师：张礼和院士
1988/9-1991/4，北京理工大学，应用化学，工学硕士，导师：陈恬生教授
1984/9-1988/7，河南大学，化学，学士
工作经历：
2014/6-至今， 河南师范大学，化学化工学院，特聘教授，教授
2005/12-2014/5 (美国)托马斯杰弗逊大学，医学院，助理研究员，研究员
2003/2-2005/12 (美国)爱荷华大学，药学院，博士后
1995/11-1999/8 化学工业部、国家石化局高级工程师，
1991/4-1995/11 北京市发酵工业研究所，工程师
主讲课程：
《药物设计学》《生物缀合物化学》
研究领域与兴趣：
1. 小分子肿瘤免疫治疗药物的设计合成与活性研究
2. 多肽-药物缀合物的设计合成与活性评价
主持或参加科研项目：
1. NSF22277022 国家自然科学基金面上项目 环寡核苷酸的合成及其在人和小鼠免疫细胞中的生物活性与作用靶点研究， 2023.01-2026.12，54万元，主持
2. NSF 21977025 国家自然科学基金面上项目 含三氮唑模块的环二核苷酸类似物的设计合成与免疫活性研究， 2020.1-2023.12, 66万元, 主持
3.. NSF U1604285国家自然科学基金委-河南省联合基金重点项目 2′,3′-环鸟苷腺苷酸类似物的设计、合成与构效关系研究，2017.1-2020.12, 215万元，第一参与人
4. NSF 21605041 国家自然科学基金青年基金 靶向干扰素刺激因子的免疫分子机制、虚拟筛选及生物活性研究， 2017.1-2019.12 30万元，第一参与人。
代表性论文：
1. Di Xie, Jiwei Tang, Tingting Zhang, Wenpei Dong, Jinliang Ma*, Chang-po Chen* A Bimolecular Simultaneous Macrocyclization Strategy to Synthesize Cyclic Dinucleotide Analogues with Internucleoside Guanidium Linkages. Journal of Organic Chemistry, 2025, 90, 13145-13155.
2. Peng Zhou , Gen Yang , Yan Wang , Yaya Peng , Lingyun Xu , Tao Jiang , Jinliang Ma * , Wenpei Dong * , Chang-Po Chen* Development of indole derivatives as inhibitors targeting STING-dependent inflammation. Bioogranic & Medicinal Chemistry, 2025, 126, 118216.
3. Xie, Di, Xu, Lingyun), Yuan, Shuwei, Yan, Jiayin, Zhou, Peng, Dong, Wenpei, Ma, JinliangChen, Changpo. Synthesis and biofilm inhibitory activity of cyclic dinucleotide analogues prepared with macrocyclic ribose-phosphate skeleton. Bioorganic &Medicinal Chemistry. 2025, 19, 130107
4. Jinliang Ma,* Hui Xu, Ke Hou, Yaru Cao, Di Xie, Jiayin Yan, Wenpei Dong, Tao Jiang, and Chang-Po Chen*Design and Synthesis of Cyclic Dinucleotide Analogues Containing Triazolyl C‑Nucleosides Jornal of Organic Chemistry, 2024, 89, 11380-393
5. Wang, M.; Fan, B.; Lu, W.; Ryde, U.; Chang, Y.; Han, D.; Lu, J.; Liu, T.; Gao, Q.; Chen, C.; et al. Unraveling the Binding Mode of Cyclic Adenosine–Inosine Monophosphate (cAIMP) to STING through Molecular Dynamics Simulations. Molecules 2024, 29, 2650. https://doi.org/10.3390/ molecules29112650
6. Wenpei Dong , Lingyun Xu , Chun Chang , Tao Jiang * , Chang-po Chen * , Guisheng Zhang *A novel self-assembled nucleobase-nanoffber platform of CDN to activate the STING pathway for synergistic cancer immunotherapy. Colloids and Surfaces B: Biointerfaces 232 (2023) 113597
7. Dong, W.; Chen, M.; Chang, C.; Jiang, T.; Su, L.; Chen, C.; Zhang, G. Remodeling of Tumor Microenvironment by Nanozyme Combined cGAS–STING Signaling Pathway Agonist for Enhancing Cancer Immunotherapy. Int. J. Mol. Sci. 2023, 24, 13935. https://doi.org/10.3390/ ijms241813935
8. Pengyang Xin,* Linqij Xu, Wenpei Dong, Linlin Mao, Jingjing Guo, Jingjing Bi, Shouwei Zhang, Yan Pei, Chang-Po Chen*, Synthetic K+ channels: constructed by rebuilding the core modules of natural K+ channels in an artificial system. Angewandte Chemie International Edition.2023 62, e202217859.
9. Xiao-Pan Liu, Wen-Qian Sun, Meng-Ge Zhao, Xing-Jie Zhang, Li-Hong Liu, Chang-Po Chen*. Fluoro-functionalized ionic covalent organic frameworks (F-iCOFs) for highly selective enrichment and sensitive determination of perfluorinated sulfonates by MALDI-MS.Microchimica Acta. Pub Date : 2022-11-07, DOI:10.1007/s00604-022-05542-9.
10. M. Wang, H. Wu, S. Xu*, P. Dong, A. Long, L. Xiao*, S. Feng, C.-P. Chen*, Cellulose nanocrystal regulated ultra-loose, lightweight, and hierarchical porous reduced graphene oxide hybrid aerogel for capturing and determining organic pollutants from water, Carbon, 204 (2023) 94-101.
11. S. Xu*, H. Liu, A. Long, S. Feng*, C.-P. Chen*, In-situ synthesis of carbon dots embedded wrinkled-mesoporous silica microspheres for efficiently capturing and monitoring organochlorine pesticides from water and fruit juice, Separation and Purification Technology, 306 (2023) 122589.
12. S. Xu*, H. Liu, C-P. Chen, S. Feng*, J. Fan*, Ultrasound-assisted one-step reduction and self-assembly of carbon dots-reduced graphene oxide: Mechanism investigation and solid phase microextraction of ultra-trace organochlorine pesticides, Chemical Engineering Journal, 451 (2023) 138569.
13. S. Xu*, H. Liu, A. Long, H. Li, C-P Chen, S. Feng*, J. Fan, Carbon Dot-Decorated Graphite Carbon Nitride Composites for Enhanced Solid-Phase Microextraction of Chlorobenzenes from Water, Nanomaterials, 12 (2022) 335.
14. S. Xu*, H. Li, P. Dong, M. Wang, C.-P. Chen, S. Feng, J. Fan*, High-throughput profiling volatiles in edible oils by cooling assisted solid-phase microextraction technique for sensitive discrimination of edible oils adulteration, Analytica Chimica Acta, 1221 (2022) 340159.
15. S. Xu*, P. Dong, H. Liu, H. Li, C. P Chen, S. Feng*, J. Fan, Lotus-like Ni@NiO nanoparticles embedded porous carbon derived from MOF-74/cellulose nanocrystal hybrids as solid phase microextraction coating for ultrasensitive determination of chlorobenzenes from water, Journal of Hazardous Materials, 429 (2022) 128384.
16. 董攀龙, 徐生瑞*, 胡宗杰, 李宁, 李世杰, 陈长坡*, 顶空固相微萃取-气相色谱质谱法测定人体足部气味中短链脂肪酸, 河南师范大学学报(自然科学版), 49 (2021) 76-81.
17. Panlong Dong , Hailin Liu , Shengrui Xu ,*, Changpo Chen , Suling Feng and Anying Long ,* Sheet-like Skeleton Carbon Derived from Shaddock Peels with Hierarchically Porous Structures for Ultra-Fast Removal of Methylene Blue. Water, 2021, 13, 2554
18. Xiao-Pan Liu*, Wen-Qian Sun, Tong-Xin Liu, Bing-Bing Liu, Chang-Po Chen*. Fullerenol as a water-soluble MALDI-MS matrix for rapid analysis of small molecules and efficient quantification of saccharin sodium in foods. Journal of Chromatography B, 2021, 1178, 122819.
19. 陈长坡*，闫佳音，牛美，曹冠洋，李飒，毕晶晶，董文佩，蒋涛，辛鹏洋, 环二核苷酸类似物研究进展, 河南师范大学学报(自然科学版), 2021, 49(5), 59-73.
20. S. Xu*, P. Dong, M. Qin, H. Liu, A. Long, C. P. Chen, S. Feng, H. Wu*, Core-shell structured Fe2O3/CeO2@MnO2 microspheres with abundant surface oxygen for sensitive solid-phase microextraction of polycyclic aromatic hydrocarbons from water, Microchimica Acta, 188 (2021) 337.
21. Pengyang Xin, Lingyu Zhao, Linlin Mao, Linqi Xu, Shuaimin Hou, Huiyuan Kong, Haodong Fang, Haofeng Zhu, Tao Jiang and Chang-Po Chen*. Effect of charge status on the ion transport and antimicrobial activity of synthetic channels. Chem. Commun.,2020, 56, 13796-13799.
22. Yanwei Chi, Zhiying Wang, Jie Wang, Wenpei Dong, Pengyang Xin, Jingjing Bi, Tao Jing, Chang-Po Chen*, Dimeric camptothecin-loaded mPEG-PCL nanoparticles with high drug loading and reduction-responsive drug release. Coloid and Polyer Science, 2020，298, 51-58. https//doi.org/10.1007/s00396-019-04581-8
23. Shengrui Xu, Qingqing Liu, Cuicui Wang, Li Xiao, Suling Feng, Ning Li, Chang-Po Chen*, Three-demensional prmpon -like Au/ZnO porous microspheres as solid phase microextraction coating for determination of volatile fatty acids from foot odor. Talanta, 2019, online http//doi.org/10.1016/j.talanta.2019.120519
24. Jingjing Guo，Jie Wang, Jingrong Fan, Yan Zhang, Wenpei Dong, and ChangPo Chen*,Distinct Dynamical and Conformational Features of Human STING in Response to 2'3'-cGAMP and c-di-GMP. ChemBioChem, 2019, 20(14), 1838-1847
25. Tao Jiang, Xin Wang, Ge Wang, Yafu Wang, Kui Wang, Xiaopeng Xuan, Changpo Chen,* Kai Jiang, Hua Zhang,* Light-activated “cycle reversible ICT” fluorescent probe: Monitoring of pHi trace-change induced by UV in programmed cell death.Chemical Communications, 2019, 55, 5279-5282.
26. Pengyang Xin*, Huiyuan Kong, Yonghui Sun, Lingyu Zhao, Haodong Fang, ,Haofeng Zhu, Tao Jiang, Jingjing Guo, Qian Zhang, Wenpei Dong, Chang-Po Chen* Artificial K+ Channels Formed by Pillararene-Cyclodextrin Hybrid Molecules: , Tuning Cation Selectivity and Generating Membrane Potential. Angewandte Chemie International Edition. 2019, 58(9): 2779-2784
27. 陈长坡*，李宁，徐生瑞，胡宗杰，健康人体足部挥发性物质形成及分析研究进展。河南师范大学学报(自然科学版), 2019, 47(5), 57-64.
28. Lingjun Li, Xiaofang Xing, Chi Zhang, Anlian Zhu, Xincui Fan, Chang-Po Chen, Guisheng Zhang. Novel synthesis of 5-iodo-1,2,3-triazoles using an aqueous iodination system under air. Tetrahedron Lett. 2018, 59, 3563-3566.
29. Pardeep Kumar, Suhil K. Ttripathi, Chang-Po Chen, Eric Wickstrom, Mathew L. Thakur Evaluating Ga-68 peptide conjugates for targeting VPAC receptors: stability and pharmacokinetics. Mol. Imaging Biol. 2018, DOI: 10.1007/s11307-018-1207-x
30. Pengyang Xin, * Yonghui Sun, Huiyuan Kong, Yaodong Wang, Si Tan, Jingjing Guo, Tao Jiang, Wenpei Dong, *Chang-Po Chen* A unimolecular channel fromed by dual helical peptide modified pillar[5]arene: correlating transmembrane transport properties with antimicrobial activity and haemolytic toxicity Chem. Comm. 2017, 53, 11492-11495
31. Lingling Li, Luyao Liu, Chang-Po Chen*, Fengling Cu* Green synthesis of nitrogen-doped carbon dots from ginkgo fruits and the application in cell imaging. Inorg. Chem. Comm. 2017, 86, 227-231
32. Chang-Po Chen, Rui-Yan Jing, and Eric Wickstrom* Covalent attachment of daptomycin to Ti6Al4V alloy surfaces by a thioether linkage to inhibit colonization by Staphylococcus aureusAcs Omega 2017, 2(4), 1645-1652 (DOI: 10.1021/acsomega.6b00567)
33. Pengyang Xin,* Si Tan, Yonghui Sun, Qiaojv Ren,Wenpei Dong, Jingjing Guo, Tao Jiang and Chang-Po Chen* One-pot formation of hydrazide macrocycles with modified cavities: an example of pH-sensitive unimolecular cation channels Chem. Comm. 2017, 52, 5322-5325 (DOI: 10.1039/c7cc02076g)
34. Pengyang Xin,* Si Tan, Yaodong Wang, Yonghui Sun, Yan Wang, Yuqing Xu and Chang-Po Chen* Functionalized hydrazide macrocycle ion channels showing pH-sensitive ion selectivities Chem. Comm. 2017, 53, 625-628 (DOI: 10.1039/c6cc08943g)
35. Lingjun Li* Shengqiang Ding, Yanping Yang, Anlian Zhu, Xincui Fan, Mengchao Cui*, Changpo Chen, Guisheng Zhang* Multicomponent Aqueous Synthesis of Iodo-1,2,3-triazoles:Single-Step Models for Dual Modification of Free Peptide and Radioactive Iodo Labeling Chem. Eur. J. 2017, 23, 1166 – 1172
36. Pardeep Kumar, Sushil Kumar Tripathi, Chang-Po Chen, Neil Mehta, Bishnuhari Paudyal, Eric Wickstrom, Mathew L. Thakur, Evaluation of a PACAP peptide analogue labeled with 68Ga using two different chelating agents. Cancer Biother. Radiopharm. 2016 31(1):29-36
37. , , , , , and Fluorescence detection of KRAS2 mRNA hybridization in lung cancer cells with PNA-peptides containing an internal thiazole orange .Bioconj. Chem., 2014, 25, 1697-1708
38. Paudyal, B., Zhang, K., Chen, C.P., Metha, N., Wampole, M.E., Mitchell, E. P., Gray, B. D., Mattis, J. A., Park, K.Y., Thakur, M. l., and Wickstrom, E. Determining efficacy of breast cancer therapy by PET imaging of HER2 mRNA. Nucl. Med. Biol. 2013, 40, 994-999.
39. Sanders, J. M., Wampole, M. E., Chen, C.P., Thakur, M. L., and Wickstrom, E. Effects of hypoxantine substitution in peptide nucleic acids targeting KRAS2 oncogenic mRNA molecules: theory and experiment J. Phys. Chem. B 2013117(39):11584–11595.
40. Sethi ,D.; Chen, C.P.; Jing, R.Y.; Thakur, M.L., and Wickstrom, E. Fluorescent peptide-PNA chimeras for imaging monoamine oxidase A mRNA in neuronal cells. Bioconj. Chem, 2012, 23(2):158-163.
41. Thakur, M. L.；Zhang, K.; Paudyal, B.; Devakumar, D.; Covarrubias, M.; Chen, C.-P.; Gray, B. D.; Wickstrom, E.; Pak, K.-Y. Targeting apoptosis for optical imaging of infection Mol. Imag. and Biol., 2012, 14(2), 163-171.
42. Wickstrom, E.; Chen, C.-P.; Devadhas, D.; Wampole, M.; Jin, Y.-Y.; Sanders, J. M.; Kairys, J. C.; Ankeny, M. L.; Hu, R.; Barner, K. E.; Steiner, K. V.; Thakur, M. L. Three dimensional projection environment for molecular design and surgical simulation Studies in Health Technol. and Inform. 2011, 163:691-695.
43. Chen, C. P.; Wickstrom, E. Self-Protecting Bactericidal Titanium Alloy Surface Formed by Covalent Bonding of Daptomycin BisphosphonatesBioconj. Chem.2010, 21(11), 1978–1986
44. Chen, C. P.; Kim, J.; Liu, D.; Rettig, G. R.; McAnuff, M. A.; Martin, M. E.; and Rice, K. G. Synthetic PEGylated Glycoproteins and Their Utility in Gene Delivery Bioconj. Chem. 2007, 18(2), 371-378.
45. Cesarone, G.; Edupuganti, O. P.; Chen, C. P.; Wickstrom, E. Insulin receptor substrate 1 knockdown in human MCF7 ER+ breast cancer cells by nuclease-resistant IRS1 siRNA conjugated to a disulfide-bridged D-peptide analog of insulin-like growth factor 1 Bioconj. Chem. 2007, 18(6), 1831-1840.
46. Chen, C. P.; Zeiger A. R.; Wickstrom E. Bactericidal activity of extended 9-glycyl-amido-minocycline Bioorg. Med . Chem. Lett. 2007,17, 6558-6562.
47. Chen, C. P.; Kim, J.; Steenblock, E.; Liu, D.; and Rice, K. G. Gene Transfer with Poly-Melittin PeptidesBioconj. Chem, 2006, 17(4), 1057-1062.
48. Kim, J.; Chen, C. P.; and Rice, K. G. The Proteasome Metabolizes Peptide-Mediated Nonviral Gene Delivery Systems Gene Ther. 2005, 12(21), 1581-1590.
49. Chen, C. P.; Park, Y.; Rice, K. G. An Improved Large-Scale Synthesis of PEG-Peptides for Gene Delivery J. Pept. Res. (changed name to Chemical Biology and Drug Design, ) 2004, 64(6), 237-243.
50. Chen, C. P.; Zhang, L. R.; Peng, Y. F.; Wang, X. B.; Wang, S. Q.; Zhang, L. H. A Concise Method for the Preparation of Peptide and Arginine-Rich Peptide-Conjugated Antisense OligonucleotideBioconj. Chem. 2003, 14(3), 532-538.
51. Chen, C. P.; Li, X. X.; Zhang, L. R.; Min, J. M.; Chan, J. Y. W.; Fung, K. P.; Wang, S. Q.; Zhang, L. H. Synthesis of Antisense Oligonucleotide-peptide conjugate Targeting to GLUT-1 in HepG-2 and MCF-7 Cells Bioconj. Chem. 2002,13(3), 525-529
52. Chen, C.P.; Min, J.M.; Zhang, L.H. Synthesis and Properties of Peptide-Oligonucleotide Conjugates Prog. Biochem. Biophys. 2001,28(6),783-787