孔祥会 博士 教授 博导
孔祥会，博士，二级教授，博士生导师。水产动物疾病控制河南省工程实验室主任，河南省学术技术带头人，河南省科技创新杰出青年，河南省高校创新人才，水产一级学科带头人，水产博士学位授权点带头人，河南省创新型科技团队带头人。获河南省先进工作者，河南省优秀党员，河南省职业道德建设先进个人，河南师范大学首届校园十大育人楷模等称号。现为中国水产学会理事，中国鱼类学会理事，河南省水产学会秘书长。2004年获厦门大学博士学位；2007年中科院水生所生物学博士后流动站完成博士后研究；2009-2010年在美国University of California, Los Angeles (UCLA)留学。
孔祥会教授长期以来从事水产动物免疫和疾病防控、免疫组学解析、疫苗研发和药物创新等研究，并取得重要研究成果。主持国家自然科学基金3项,主持国家863项目子课题、河南省科技创新杰出青年计划和河南省重点科技攻关项目等20余项；参与完成国家自然科学基金重点项目、国家973项目子课题、国家“蓝色粮仓”重点专项等。在Aquaculture, Vaccine, Fish Shellfish Immun, J Fish Dis，中国科学和科学通报等重要学术刊物上发表学术论文160余篇，其中SCI源期刊收录论文80余篇。出版学术专著3部，授权国家发明专利5项，获河南省科技奖励3项。
▊已取得的创新性成果
孔祥会教授创新性成果及科学发现主要有：（1）采用分子免疫学、免疫组学和生物信息学等技术方法，系统研究了病原感染后水产动物免疫响应模式、信号调控通路及其免疫调节机制。学术成果发表在Aquaculture、Fish & Shellfish Immunology等期刊发表。此外，还分别研究了抗菌肽、抗氧化酶、溶菌酶等不同的天然免疫相关基因及其对病原体的响应。（2）系统研究了水产动物重要病原的生物学和流行病学，弄清病原与机体互作、入侵致病过程及其致病机制，为疾病防控提供指导。取得的重要学术成果已在Aquaculture、Journal of fish disease等期刊发表上发表。（3）水产动物疫苗研发和疫苗导入技术。针对重要致病病原，研究和制备高效的灭活疫苗、弱毒疫苗和亚单位疫苗。取得的重要成果已在Vaccine、Fish & Shellfish Immunology等期刊发表；团队自行研发的超声波和高渗食盐辅助浸浴法高效疫苗导入技术，对小规格鱼种免疫有独到优势，已推广应用2000余亩，获得较好的经济效益和生态效益。（4）新型绿色渔药创制。利用代谢组学筛选水产动物小分子代谢物，作为渔药增效剂，以大幅减量渔药使用。研发适用于水产动物的中草药制剂和免疫增加剂，以增强机体免疫，预防疾病的发生。
▊代表性科研项目
（1）主持国家自然科学基金联合基金项目（U2004154），项目名称：嗜水气单胞菌感染后黄河鲤IL-1β生成和分泌调控的分子机制研究，在研，项目执行期：2021-2023。
（2）主持国家自然科学基金联合基金项目(U1604104)，项目名称：草鱼pIgR受体结合和转运IgM的分子机制研究，结项。
（3）主持国家自然科学基金项目(30770299)，项目名称: 尺寸控制基因调控序列在鲤科鱼类中的变异及系统演化，结项。
（4）主持河南省科技创新杰出青年计划(124100510017)，项目名称：鱼类组蛋白H2B衍生抗菌肽基因变异对抗菌影响及高活性抗菌肽筛选，结项。
（5）主持河南省高校科技创新团队支持计划（15IRTSTHN018），团队名称：水产动物医学，结项。
（6）主持河南省高校科技创新人才支持计划(2011HASTIT012)，项目名称：鱼类低氧诱导因子HIF-1α分子进化和基因改造及作用研究，结项。
▊代表性学术论文
孔祥会近5年以第一作者或通讯作者发表的代表性论文：
【1】Yuan Gaoliang#, Zhu Lei#, Jiang Xinyu, Zhang Jie, Pei Chao, Zhao Xianliang, Li Li, Kong Xianghui*. Diagnosis of co-infection with white spot syndrome virus and Aeromonas veronii in red swamp crayfish Procambarus clarkia. Aquaculture, 2021,532: 736010.
【2】Zhu Lei#, Yuan Gaoliang#, Jiang Xinyu, Zhang Jie, Zhao Xianliang, Pei Chao, Li Li, Kong Xianghui*. Molecular characterization of Rab5 and Rab6, and their involvement in innate immunity in red swamp crayfish Procambarus clarkia. Aquaculture, 2021,533: 736085.
【3】Zhu Lei, Gao Yuanyuan, Yuan Gaoliang, Jiang Xinyu, Zhang Jie, Zhao Xianliang, Pei Chao, Li Li, Kong Xianghui*. Identification and immune functional analysis of a novel C1q domain-containing protein in Yellow River Carp (Cyprinus carpio L.). Aquaculture, 2021,534: 736313.
【4】Wang Li, Zhang Jie, Zhao Xianliang, Pei Chao, Li Li, Kong Xianghui*. Molecular characterization and biological function of a tandem-repeat galectin-9 in Qihe crucian carp Carassius auratus. Fish and Shellfish Immunology, 2020,103: 366-376.
【5】Wu Limin, Li Yongjing, Xu Yufeng, Wang Lei, Ma Xiao, Dong Chuanju, Zhao Xianliang, TianXue, Li Xuejun*, Kong Xianghui*. The roles of two myostatins and immune effects after inhibition in Qi river crucian carp (Carassius auratus). Fish & Shellfish Immunology, 2020, 98: 710-719.
【6】Zhao Xian-liang, Wu Gan, Chen He, Li Li, Kong Xiang-hui*. Analysis of virulence and immunogenic factors in Aeromonas hydrophila: Towards the development of live vaccines. Journal of Fish Disease, 2020,43:747-755.
【7】Zhang Jie, Zhu Yachen, Chen Zhuo, Li Chunjing, Zhao Xianliang, Kong Xianghui*. Molecular cloning and expression analysis of MyD88 and TRAF6 in Qihe crucian carp Carassius auratus. Fish and Shellfish Immunology, 2019, 87: 829-838.
【8】Gao Yan, Pei Chao, Sun Xiaoying, Zhang Chao, Li Li, Kong Xianghui*. Novel subunit vaccine based on grass carp reovirus VP35 protein provides protective immunity against grass carp hemorrhagic disease. Fish and Shellfish Immunology, 2018, 75:91-98.
【9】Zhao Xianliang, Chen He, Jin Zhaohui, Li Li, Zhang Jie, Kong Xianghui*. GC-MS-based metabolomics analysis reveals L‐aspartate enhances the antibiotic sensitivity of neomycin sulfate-resistant Aeromonas hydrophila. Journal of fish diseases, 2018, 41(12): 1831-1841.
【10】Gao Yan #, Pei Chao #, Sun Xiaoying, Zhang Chao, Li Li, Kong Xianghui*. Plasmid pcDNA3.1-s11 constructed based on the S11 segment of grass carp reovirus as DNA vaccine provides immune protection. Vaccine, 2018, 36:3613-3621.
【11】Kong Xianghui*, Wang Li, Pei Chao, Zhang Jie, Zhao Xianliang, Li Li. Comparison of polymeric immunoglobulin receptor between fish and mammals. Veterinary Immunology and Immunopathology, 2018,202: 63-69.
【12】Zhao Xianliang, Chen He, Zhong Keke, Li Li, Kong Xianghui*. Myo-inositol as an adjuvant to florfenicol against Aeromonas hydrophila infection in common carp Cyprinus carpio. FEMS Microbiology Letters, 2018, 365(20): fny212.
【13】Zhang Jie, Wang Li, Zhao Yanjing, Kong Xianghui*, Wu Fan, Zhao Xianliang. Molecular characterization and expression analysis of toll-like receptors 5 and 22 from natural triploid Carassius auratus.Fish and Shellfish Immunology,2017,64:1-13.
【14】Kong Xianghui*, Wu Xiangmin, Pei Chao, Zhang Jie, Zhao Xianliang, Li Li, Nie Guoxing, Li Xuejun. H2A and Ca-L-hipposin gene: Characteristic analysis and expression responses to Aeromonas hydrophila infection in Carassius aurutus. Fish and Shellfish Immunology, 2017,63: 344-352.
【15】Di Guilan, Li Hui, Zhang Chao, Zhao Yanjing, Zhou Chuanjiang, Naeem Sajid, Li Li, Kong Xianghui*. Label-free proteomic analysis of intestinal mucosa proteins in common carp (Cyprinus carpio) infected with Aeromonas hydrophila. Fish and Shellfish Immunology, 2017, 66: 11-25.
【16】Wang Li, Zhang Jie, Kong Xianghui*, Zhao Xianliang, Pei Chao, Li Li. A C-type lectin, Nattectin-like protein (CaNTC) in Qihe crucian carp Carassius auratus: Binding ability with LPS, PGN and various bacteria, and agglutinating activity against bacteria. Fish and Shellfish Immunology, 2017, 67: 382-392.
【17】Kong Xianghui*, Qiao Dan, Zhao Xianliang, Wang Li, Zhang Jie, Liu Dandan , Zhang Hongxu. The molecular characterizations of Cu/ZnSOD and MnSOD and its responses of mRNA expression and enzyme activity to Aeromonas hydrophila or lipopolysaccharide challenge in Qihe crucian carp Carassius auratus. Fish and Shellfish Immunology, 2017, 67: 429-440.
【18】Wang Li, Zhang Jie, Kong Xianghui*, Pei Chao, Zhao Xianliang, Li Li. Molecular characterization of polymeric immunoglobulin receptor and expression response to Aeromonas hydrophila challenge in Carassius auratus. Fish and Shellfish Immunology, 2017, 70: 372-380.
【19】Zhao Yanjing, Jiang Xinyu, Kong Xianghui*, Di Guilan, Nie Guoxing，Li Xuejun. Effects of hypoxia on lysozyme activity and antioxidant defences in the kidney and spleen of Carassius auratus. Aquaculture Research, 2017, 48: 223-235.
【20】Wang Meijuan, Zhao Xianliang, Kong Xianghui*, Wang Li, Jiao Dan, Zhang Hongxu. Molecular characterization and expressing analysis of the c-type and g-type lysozymes in Qihe crucian carp Carassius auratus. Fish and Shellfish Immunology, 2016, 52: 210-220.
【21】Jiang Xinyu, Zhang Chao, Zhao Yanjing, Kong Xianghui*,Pei Chao, Li Li, Nie Guoxing, Li Xuejun. Immune effects of the vaccine for live attenuated Aeromonas hydrophila screened using rifampicin on common carp (Cyprinus carpio L.). Vaccine, 2016, 34(27):3087-3092.
【22】Zhang Jie, Chen Zhuo, Zhou Chuanjiang, Kong Xianghui*. Molecular phylogeny of the subfamily Schizothoracinae (Teleostei: Cypriniformes: Cyprinidae) inferred from complete mitochondrial genomes. Biochemical Systematics and Ecology, 2016,64: 6-13.
【23】Jiang Hongxia, Kong Xianghui*, Wang Shuping, Guo Huiyun. Effect of copper on growth, digestive and antioxidant enzyme activities of juvenile Qihe crucian carp during exposure and recovery. Bulletin of Environmental Contamination and Toxicology, 2016, 96:333-340.
【24】赵燕静，狄桂兰，孔祥会*，张杰，李莉，聂国兴，李学军. 低氧环境下poly I:C刺激对淇河鲫肝胰脏抗氧化防护的影响，水产学报，2016, 40: 1830-1841.
▊科研团队理念
做一流学问，树一流人品，育一流人才
▊研究生招生和博士后入站
硕士生招生：水产一级硕士点
学术型硕士：水产动物医学方向；
专业型硕士：水产动物疾病防控方向。
博士生招生：水产一级博士点
招生方向：水产动物医学（水产动物免疫和疾病防控）；
博士后入站：生物学博士后流动站常年招收博士后
▊联系方式
河南省新乡市建设路46号，河南师范大学水产学院，邮编：453007
电子邮件：xhkong@htu.cn；xhkong@htu.edu.cn
欢迎有志之士加盟我们的科研团队，走进科学殿堂，探索科学奥秘。
