朱博，男，博士，副教授，硕士生导师。
入选博士后创新人才支持计划
河南省优秀青年科学基金获得者
河南省青年拔尖人才（D类）
E-mail：zbtiantang@126.com；zhubo2019@htu.edu.cn
教育经历：
2005.09—2009.07 河南大学 药学院 药学
2009.09—2012.07 河南大学 药学院 药物化学
2013.09—2016.7 河南大学 化学化工学院 分析化学
工作经历：
2012.08—2013.08 漯河医学高等专科学校 药学系 辅导员
2016.07—2017.04 漯河医学高等专科学校 药学系 讲师
2017.04—2019.06 河南师范大学 化学化工学院 博士后
2019.06—2020.04 河南师范大学 化学化工学院 讲师
2020.04—2023.04 河南师范大学 化学化工学院 副教授
2023.04—至今 河南师范大学 抗病毒性传染病创新药物全国重点实验室 副教授
主讲课程：
本科：《有机化学实验》、《现代化学进展》
研究生：《药物合成中的元素化学》
研究领域与兴趣：
核苷类抗病毒活性分子的精准设计合成
抗肿瘤药物设计合成及活性研究
抗抑郁药物设计合成及活性研究
近年来主持的主要科研项目：
国家自然科学基金—指南引导类原创探索计划子课题（2022），在研，主持；
河南省自然科学基金优秀青年基金（2021），在研，主持；
国家自然科学基金（2019，81903465），结题，主持；
博士后创新人才支持计划,（2017），结题，主持；
博士后面上基金（2017），结题，主持。
获奖情况：
河南师范大学立德树人先进个人（2023）；
新乡市文明教师（2022）；
河南师范大学急难险重先进个人（2021）；
新乡市抗击新冠肺炎疫情先进个人（2020）。
代表性论文：
(31) Wang, M.; Li, L.; Yang, S.; Guo, F.; Zhu, G.*; Zhu, B.*; Chang, J.* Synthesis of novel oxazol-5-one derivatives containing chiral trifluoromethyl and isoxazole moieties as potent antitumor agents and the mechanism investigation. Bioorg Chem, 2023, 135, 106505.
(30) Zhu, B.*; Zhang, T.; Yu, Y.; Pan, D.; Mao, H.; Zhu, G.; Chang, J.* Synthesis of γ-hydroxy-γ-perfluoroalkyl butenolides and exocyclic double bond butanolides via regioselective allylic alkylations of MBH carbonates with 2-perfluoroalkyl-oxazol-5(2H)-ones. Organic Chemistry Frontiers,2022, 9, 2955-2962.
(29) Zhu, B.*; Sun, H.; Fan, H.; Wang, M.; Guo, F.; Zhai, Y.; Zhu M.; Chang, J.*Asymmetric Brønsted base-catalyzed aza-Michael addition and [3+2] cycloaddition reactions of N-ester acylhydrazones and enones. Organic Chemistry Frontiers, 2022, 9, 6631-6639.
(28) Yao, E. Z.; Chai, G. L.*; Zhang, P.; Zhu, B.; Chang, J.* Chiral dihydroxytetraphenylene-catalyzed enantioselective conjugate addition of boronic acids to β-enaminones. Organic Chemistry Frontiers, 2022, 9, 2375-2381.
(27) Zhu, B.*, Fan, H., Ding, Y., Zhai, Y., Wang, L., Wang, M., Zhu, G., Chang, J.* Copper(I)-catalyzed asymmetric [3 + 2] cycloaddition of N-ester acylhydrazones an β-trifluoromethyl-α,β-unsaturated ketones. Organic Chemistry Frontiers, 2022, 9, 5544-5550.
(26) Zhu, B.*; Yang, T.; Gu, Y.; Zhu, S.; Zhu, G.; Chang, J*. Enantioselective organocatalytic amination of 2-perfluoroalkyl-oxazol-5(2H)-ones towards the synthesis of chiral N,O-aminals with perfluoroalkyl and amino groups. Organic Chemistry Frontiers, 2021, 8, 4160-4165.
(25) Yang, H.; Lu, S.; Wang, S.; Liu, L.; Zhu, B.; Yu, S.; Yang, S.*; Chang, J.* Evolution of the protein corona affects macrophage polarization. Int J Biol Macromol, 2021,191, 192-200.
(24) Zhang, J.; Li, Y.; Wang, L.; Liu, H.; Lu, S.; Liu, Y.; Li, K.; Liu, B.; Li, S.; Shao, F.; Wang, K.; Shen, M.; Li, R.; Cui, J.; Sun, P.; Ma, C.; Zhu, B.; Wang, Z.; Wan, Y.; Yu, S.; Che, Y.; Wang, C.; Wang, C.; Zhang, Q.; Zhao, L.; Peng, X.*; Cheng, Z.; Chang*, J.*; Jiang, J*. Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients. Signal Transduction and Targeted Therapy, 2021, 6, 414.
(23) 李路瑶,徐鑫尧,朱博*,常俊标*. 吡唑酮化合物在催化不对称反应中的应用. 化学进展, 2020, 32, 1710-1728.
(22) Li, L.; Yang, T.; Zhang, T.; Zhu, B.*; Chang, J.* Organocatalytic Asymmetric Tandem Cyclization/Michael Addition via Oxazol-5(2H)-One Formation: Access to Perfluoroalkyl-Containing N,O-Acetal Derivatives. J. Org. Chem. 2020, 85, 12294-12303.
(21) Li, L.; Zhu, B.*; Fan, H.; Jiang, Z.; Chang, J.* Direct organocatalytic asymmetric Michael reaction of fluorine hemiaminal-type nucleophile to 4-nitro-5-styrylisoxazoles. Organic Chemistry Frontiers2020, 7, 1343–1348.
(20) Xu, X.; He, Y.; Zhou, J.; Li, X.; Zhu, B.*; Chang, J.* Organocatalytic Asymmetric Michael Addition of Pyrazol-5-ones to β Trifluoromethyl-α,β-unsaturated Ketones: Stereocontrolled Construction of Vicinal Quaternary and Tertiary Stereocenters. J. Org. Chem. 2020, 85, 574−584.
(19) Lu, B.; Xin, S.; Zhu, B.*; Chang, J.* Enantioselective Conjugate Addition–Protonation of 5H-Oxazol-4-ones and 5-Methylene 1,3-oxazolidine-2,4-diones: 2,2'-Biphenol-Induced Diastereoselectivity Switch. Chin. J. Chem. 2019, 37, 689-694.
(18) Zhu, B.; Lu, B.; Zhang, H.; Xu, X.; Jiang, Z.*; Chang, J.* Phase-Transfer-Catalyzed, Enantioselective Vinylogous Conjugate Addition−Cyclization of Olefinic Azlactones To Access Multifunctionalized Chiral Cyclohexenones. Org. Lett.2019, 21, 3271-3275.
(17) Chai, G.; Zhu, B.; Chang, J.* Synthesis and Application of Substituted 1,16-Dihydroxytetraphenylenes in Catalytic symmetric Allylboration of Ketones. J. Org. Chem. 2019, 84, 120–127.
(16) Xia, X.; Zhu, Q.; Wang, J.; Chen, J.; Cao, W.; Zhu, B.*; Wu, X.* Direct Asymmetric Vinylogous Mannich Addition of 3,5-Disubstituted-4-nitroisoxazoles to Isatin-Derived Imines Catalyzed by a Bifunctional Phase-Transfer-Catalyst. J. Org. Chem. 2018, 83, 14617–14625.
(15) Zhu, B.; Li, F.; Lu, B.; Chang, J.*; Jiang, Z.* Organocatalytic Enantioselective Vinylogous Aldol Reaction of 5-Alkyl-4-Nitroisoxazoles to Paraformaldehyde. J. Org. Chem.2018, 83, 11350–11358.
(14) Zhu, B.; Lee, R.; Yin, Y.; Li, F.; Coote, M.*; Jiang, Z.* Enantioselective Vinylogous Amination of 5-Alkyl-4-nitroisoxazoles with a Dipeptide-Based Guanidinium Phase-Transfer Catalyst. Org. Lett. 2018, 20, 429−432.
(13) Li, S.; Zhu, B.(共一); Lee, R.; Qiao, B.; Jiang, Z.* Visible light-induced selective aerobic oxidative transposition of vinyl halides using a tetrahalogenoferrate(III) complex catalyst. Organic Chemistry Frontiers.2018, 5, 380−385.
(12) Zhu, B.; Qiu, S.; Li, J.; Coote, M. L.; Lee, R.; Jiang, Z.* Asymmetric [4+2] annulation of 5H-thiazol-4-ones with a chiral dipeptide-based Brønsted base catalyst. Chem. Sci.2016, 7, 6060–6067.
(11) Zhu, B.; Lee, R.; Li, J.; Ye, X.; Hong, S.-N.; Qiu, S.; Coote, M. L.; Jiang, Z.* Chemoselective Switch in Asymmetric Organocatalysis of 5H-oxazol-4-ones and N-Itaconimides towards Tandem Conjugate Addition−Protonation or [4+2] Cycloaddition. Angew. Chem. Int. Ed.2016, 55, 1299−1303.
(10) Zhao, X.; Zhu, B.; Jiang, Z.* Acyclic Amino Acid-Based Bifunctional Chiral Tertiary Amines, Quaternary Ammoniums and Iminophosphoranes as Organocatalysts. Synlett 2015, 26, 2216−2230.
(9) Zhu, B.; Zhang, W.; Lee, R.; Han, Z.; Yang, W.; Tan, D.; Huang, K.-W.; Jiang, Z.* Direct Asymmetric Vinylogous Aldol Reaction of Allyl Ketones with Isatins: Divergent Synthesis of 3-Hydroxy-2-Oxindole Derivatives. Angew. Chem. Int. Ed. 2013, 52, 6666–6670 (Selected as the inside back cover picture of Angewandte Chemie) (Highlighted by Synfacts 2013, 9, 0784–0784; Contributors: Benjamin List, Mattia Riccardo Monaco).
(8) Zhu, B.; Yan, L.; Pan, Y.; Lee, R.; Liu, H.; Han, Z.; Huang, K.-W.; Tan. C.-H.; Jiang, Z. Lewis Base Catalyzed Enantioselective Allylic Hydroxylation of Morita-Baylis-Hillman Carbonates with Water. J. Org. Chem. 2011, 76, 6894–6900.
(7) Tong, G.; Zhu, B.; Lee, R.; Yang, W.; Tan, D.; Yang, C.; Han, Z.; Yan, L.; Huang, K.-W.; Jiang, Z.* Highly Enantio- and Diastereoselective Allylic Alkylation of Morita-Baylis-Hillman Carbonates with Allyl Ketones. J. Org. Chem. 2013, 78, 5067–5072.
(6) Qiu, S.; Lee, R.; Zhu, B.; Coote, M. L.; Zhao, X.; Jiang, Z.* Highly Enantio- and Diastereoselective [4 + 2] Cycloaddition of 5H oxazol-4-ones with N Maleimides. J. Org. Chem. 2016, 81, 8061−8069.
(5) Yan, L.; Han, Z.; Zhu, B.; Yang, C.; Tan, C.-H.; Jiang, Z.* Asymmetric Alylic Alkylation of Morita-Baylis-Hillman Carbonates with α-Fluoro-β-Keto Esters. Beilstein J. Org. Chem. 2013, 9, 1853–1857.
(4) Li, J.; Qiu, S.; Ye, X.; Zhu, B.; Liu, H,; Jiang, Z.* Dipeptide-Based Chiral Tertiary Amine-Catalyzed Asymmetric Conjugate Addition Reactions of 5H-Thiazol/Oxazol-4-Ones. J. Org. Chem. 2016, 81, 11916−11923.
(3) Jiang, Z.; Bai, X.; Chen, W.; Zhang, G.; Zhu, B.; Jiang, Z.* Organocatalytic Enantioselective Vinylogous Aldol Reaction of Allyl Ketones to Activated Acyclic Ketones. Org. Lett. 2016, 18, 260−263.
(2) Yang, C.; Chen, W.; Yang, W.; Zhu, B.; Yan, L.; Tan, C.-H.; Jiang, Z.* Bicyclic-Guanidine-Catalyzed Asymmetric Michael Addition of 3-Substituted Oxindoles to 2-Cyclopentenone. Chem. Asian J. 2013, 8, 2960−2964.
(1) Yang, W.; Wei, X.; Pan, Y.; Lee, R.; Zhu, B.; Liu, H.; Yan, L.; Huang, K.-W.; Jiang, Z.*; Tan, C.-H. Highly Enantio- and Diastereoselective Synthesis of β-Methyl-γ- Monofluoromethyl-Substituted Alcohols. Chem. Eur. J. 2011, 17, 8066−8070.