渠桂荣个人简介

姓名：

渠桂荣

职称：

教授、博士生导师

办公电话：

0373-3329276

电子邮箱：

quguir@sina.com

个人简介：

渠桂荣,教授、博士生导师，1976年在本校毕业后留校任教至今。主讲课程有《波谱分析与实验》、《有机化学》、《绿色化学》、《天然药物化学》、《现代化学实验技术》等。现任国家级有机化学教学团队第一负责人、河南省有机重点学科点第一学术带头人，功能有机分子化学与技术河南省高校重点学科开放实验室主任。兼任河南省化学会常务理事，河南省化学会有机专业委员会主任。河南省劳动模范、河南省十大女杰、全国模范教师、全国三八红旗手、享受国务院特殊津贴专家、国家级教学名师奖获得者。在Chem. Eur. J..，Chem.Comm., Green Chem.,   J.Org.Chem. Org. Lett. 等SCI期刊发表论文100余篇，被SCI引用1000余次。受理国家发明专利10项。

研究领域：

1.有机合成
2.核苷类化合物的合成与产业化
3.天然产物的分离、结构鉴定与合成

主要学术及社会兼职：

现任国家级有机化学教学团队第一负责人、河南省有机重点学科点第一学术带头人，功能有机分子化学与技术河南省高校重点学科开放实验室主任。兼任河南省化学会常务理事，河南省化学会有机专业委员会主任。

主持或参加科研项目情况：

1.国家自然科学基金（21172059）: 基于C-H键活化的偶联反应绿色合成荧光修饰的核苷类化合物

2.国家自然科学基金（20772024）：脱氧及核苷的绿色合成研究

3.国家自然科学基金（20372018）：微波技术合成核苷类化合物的新方法研究

4.国家自然科学基金（29972010）：裂叶苣荬菜抗乙型肝炎病毒活性成分的研究

5.河南省杰出人才创新基金（074200510020）核苷类化合物的绿色合成研究
6.河南省重点引智项目，（L20064100009）脱氧核苷的合成及产业化研究

7.拓新生化科技有限公司横向项目关于“联合开发核苷类化合物”
的技术合作协议

8.拓新生化科技有限公司横向项目关于“联合开发阿糖核苷类化合物”
的合同

学术成果：

代表性论文：

[1] Gui-Rong Qu,* Hong-Liang Zhang, Hong-Ying Niu, Zai-Kun Xue, Xin-Xin Lv, Hai-Ming Guo*, Synthesis of C6-Azolyl Purine Nucleosides via C-N Coupling Reaction of Unprotected 6-Chloropurine Nucleosides and N-Heterocycles under Catalyst- and Solvent-Free Conditions, Green Chem, 2012, DOI: 10.1039/c0xx00000x.
[2] Gui-Rong Qu,* Yan-Wei Song, Hong-Ying Niu, Hai-Ming Guo,* John S. Fossey, Cu(OTf)2-catalyzed Ritter reaction: Efficient synthesis of amides  from nitriles and halohydrocarbons in water, RSC Adv, 2012, DOI:10.1039/C2RA20941A.
[3] Peng-Yang Xin, Hong-Ying Niu, Gui-Rong Qu,* Rui-Fang Ding, Hai-Ming Guo*, Nickel catalyzed alkylation of N-aromatic heterocycles with Grignard reagents through direct C-H bond functionalization, Chem. Commun, 2012, DOI:10.1039/C2CC32396F.
[4] Peng-Yang Xin, Hong-Ying Niu, Gui-Rong Qu,* Rui-Fang Ding, Hai-Ming Guo*Nickel-Catalyzed sp2 C-H Bonds Arylation of N-Aromatic Heterocycles with Grignard Reagents at Room Temperature Chem. Commun 2011, 47, 11140-11142.
[5] Hai-Ming Guo*TtengFei-Yuan Hong-Ying Niu, JinYing-Liu , Run-Ze Mao Gui-Rong Qu,* , Highly Enantioselective Synthesis of Designed Chiral Acyclonucleosides and Acyclonucleotides via Organocatalytic Aza Michael Addition Chem. Eur. J. 2011, 17: 4095–4098
[6] Hai-Ming Guo*Wei-Hao Rao Hong-Ying Niu, Li-Li Jiang ,Ge-Meng,   Jia-Jia Jin Xi-Ning Yang, Gui-Rong Qu,* Palladium-Catalyzed C-H Bond Functionalization of C6-Arylpurines, chemical communications2011, 47,  5608-5610
[7] Gui-Rong Qu,*TtengFei-Yuan Hong-Ying Niu, Xin Jin, Xiao-Ting Guo, Xi-Ning Yang, Hai-Ming Guo* Microwave Promoted Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions of 6-Chloropurines with Sodium Tetraarylborate in Water, Tetrahedron 2011, 47, 9099-9103
[8] Hai-Ming Guo*, Li-Li Jiang , Hong-Ying Niu,Wei-Hao Rao Lei Liang, , Run-Ze Mao ,De-Yang Li, Gui-Rong Qu,*Pd(II)-Catalyzed Ortho Arylation of 6-Arylpurines with Aryl Iodides via Purine-Directed C−H Activation: A New Strategy for Modification of 6-Arylpurine   Derivatives, Organic Letters2011, 13(8), 2008–2011
[9] Hong-Ying Niu, Chao Xia, Gui-Rong Qu*, Shan Wu, Yi Jiang, Xin Jin, Hai-Ming Guo*, Microwave Promoted One-Pot Synthesis of 4-Nitrobenzylthioinosine Analogues Using Thiourea as a Sulfur Precursor, Chem. Asian J., 2012, 7,   45-49.
[10] Jia-Jia Jin, Hong-Ying Niu, Gui-Rong Qu, Hai-Ming Guo,* John S. Fossey*, Copper-catalysed addition of -alkyl azaarenes to ethyl glyoxylate via direct C(sp3)-H activation, RSC Adv., 2012, DOI:10.1039/C2RA20627G.
[11] Gui-Rong Qu*, Ran Xia, Xi-Ning Yang, Jian-Guo Li, Dong-Chao Wang, Hai-Ming Guo*
Synthesis of Novel C6-phosphonated Purine Nucleosidis Under Microwave Irradiation by SNAr-Arbuzov Reaction.J.Org.Chem .2008,73,2416-2419
[12] Gui-Rong Qu*, Bo Ren, Hong-Ying Niu, Zhi-Jie Mao, Hai-Ming Guo*A Novel One-step Method for The Synthesis of C-5-substituted O6,5’-Cyclopyrimidine Nucleoside Analogues In Ammonia Water.  J.Org.Chem 2008,73,2450-2453
[13] Gui-Rong Qu*, Lin Zhao, Dong-Chao Wang, Jing Wu, Hai-Ming Guo*Microwave-Promoted Efficient Synthesis of C6-cyclo Secondary Amine Substituted Purine Analogues in Neat Water,Green Chem. 2008, 10, 287-289
[14] Gui-Rong Qu*, Zhi-Jie Mao, Hong-Ying Niu, Dong-Chao Wang, Chao Xia, Hai-Ming Guo*,Straightforward and Highly Efficient Catalyst-Free One-Step Synthesis of 2-(Purin-6-yl)acetoacetic Acid Ethyl Esters, (Purin-6-yl)acetates, and 6-Methylpurines through SNAr-Based Reactions of 6-Halopurines with Ethyl Acetoacetate, Org. Lett. 2009, 11 (8), 1745-1748.
[15] Gui-Rong Qu*, Jing Wu, Yan-Yan Wu, Feng Zhang Hai-Ming Guo*,Synthesis of novel 6-[N, N-bis(2-hydroxyethyl)amino]purine nucleosides under microwave irradiation in neat water, Green Chem., 2009, 11, 760-762.
[16] Hai-Ming Guo*, Peng-Yang Xin, Hong-Ying Niu, Dong-Chao Wang, Yi Jiang, Gui-Rong Qu*,Microwave Irradiated C6-Functionalization of 6-Chloropurine Nucleosides with Various Mild Nucleophiles under Solvent-Free Condition, Green Chem., 2010,  12, 2131-2134.
[17] Hai-Ming Guo*, Pu Li, Hong-Ying Niu, Dong-Chao Wang, Gui-Rong Qu*,Direct Synthesis of 6-Arylpurines by Reaction of 6-Chloropurines with Activated Aromatics, J. Org. Chem,2010, 75, 6016-6018.
[18] Hai-Ming Guo*, Yan-Yan Wu, Hong-Ying Niu, Dong-Chao Wang, Gui-Rong Qu*,Synthesis of Acyclic Nucleosides with a Chiral Amino Side Chain by the Mitsunobu Coupling Reaction, J. Org. Chem, 2010, 75, 3863-3866.
[19] Hai-Ming Guo,a,* Chao Xia,a Hong-Ying Niu,b Xiao-Ting Zhang,a Si-Nan Kong,a Dong-Chao Wang, and Gui-Rong Qua,* Intermolecular Hydrogen Abstraction Reaction between Nitrogen Radicals in Purine Rings and Alkyl Ethers: A Highly Selective Method for the Synthesis of N-9 Alkylated Purine Nucleoside Derivatives. Adv. Synth. Catal. 2011, 353, 53 – 56
[20] Hai-Ming Guo*, Jing Wu, Hong-Ying Niu, Dong-Chao Wang, Feng Zhang, Gui-Rong Qu*,Synthesis of Novel Fluorescent Purine analogues Modified by Azacrown Ether at C6, Bioorg. Med. Chem. Lett., 2010, 20, 3098-3102.

专利成果：

(1)渠桂荣，董春红，杨西宁，蔡玉瑛，田郑刚，郭海明，王秀强
专利名称：化学合成法生产腺苷的工艺
授权时间：2005.01 授权编号：ZL 01127525.1

(2)渠桂荣，杨西宁，申艳红，董春红，郭海明，王秀强，王东超
专利名称：化学合成法生产胞苷的工艺
授权时间：2009.05 授权编号：ZL200710053853.1

(3)渠桂荣，杨西宁，郭海明，蔡玉瑛，何元庆，王秀强，徐绍红，李建平
专利名称：化学合成法生产2，6-二氯嘌呤核苷的工艺
授权时间： 2009.02      授权编号： ZL 200710053919.7
(4)郭海明，渠桂荣，吴静，王东超，杨西宁，张新迎，牛红英，夏然，王菲菲，蔡玉瑛，王秀强

专利名称：具有抗癌活性的6-位被单氮杂冠醚修饰的嘌呤核苷类新化合物及制备方法

授权时间：2010.12 授权编号：No 200910064796.6

奖励：

(1)渠桂荣等《系列核苷生产新工艺》2007年获国家科技进步二等奖。

(2)渠桂荣等《化学法生产腺苷的工艺》2006年获中国发明专利奖优秀奖。
(3)渠桂荣*，赵琳，王东超吴静，郭海明发表在Green Chem. 2008,10,295-29上的论文：Microwave-Promoted Efficient Synthesis of C6-cyclo Secondary Amine Substituted Purine Analogus In neat Water，2010年获河南省自然

科学优秀论文一等奖。

(4)渠桂荣*，夏然，郭海明，杨西宁，王东超发表在 J.Org.Chem 2008,73,2416-2419 上的论文：Synthesis of Novel C6-Phosphonated Purine Nucleosides under Microwave Irradiation by SNAr-Arbuzov Reaction  2010年获河南省自然科学优秀论文二等奖。
(5)渠桂荣*，任博，牛红英 毛志杰，郭海明，发表在 J.Org.Chem 2008,73,2450-2453 的论文：A Novel One-Step Method for the Synthesis of C-5-substituted O6,5′-cyclopyrimidine Nucleoside Analogues in Ammonia Water 2010年4月，获得河南省自然科学优秀论文奖，二等奖。
(6)渠桂荣，毛志杰，牛红英，王东超发表在的论文Straightforward and Highly Efficient Catalyst-Free One-Step Synthesis of 2-(Purin-6-yl)acetoacetic Acid Ethyl Esters, (Purin-6-yl)acetates, and 6-Methylpurines through SNAr-Based Reactions of 6-Halopurines with Ethyl Acetoacetate， 2011年1月，获得河南省自然科学优秀论文奖，一等奖。