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毕晶晶:博士,副教授,硕士生导师

Email: bijingjing2008@126.com


 

 

 


教育与研究经历:

2015.7-至今  河南师范大学,化学化工学院,教师

2009.9-2015.6中国科学院生态环境研究中心   获博士学位

2009.9-2012.6河南师范大学化学与环境科学学院,获硕士学位

2005.9-2009.6 河南师范大学化学与环境科学学院,获学士学位

主讲课程:

本科生课程:《药物合成反应基础》,《药物分析》,《化学导论》

研究生课程:《高等药物合成》

研究领域与兴趣:

1.绿色有机合成化学

2.糖化学生物学

3.功能化人工离子通道

近年来主持的主要科研项目:

1.国家自然科学青年基金,编号:21702051,高效诱导Th2型免疫应答的α-半乳糖脂三氮唑类模拟物的设计合成与活性研究。主持,26万,2018.01-2020.12

2.河南省博士后科研项目资助编号:001802033选择性激活T细胞免疫应答的新型α-GalCer氨基酸酯类模拟物的设计合成与活性研究,主持,8万,2018.12-2020.12

3.河南省高等学校重点科研项目计划,编号:17A350006TPE-糖共聚物荧光探针的构建及其应用研究。主持,3万,2017.01.01-2018.12.31

4.中科院生态环境研究中心环境化学与生态毒理学国家重点实验室开放基金,编号:KF2016-01,一类新颖双三唑类不对称汞离子荧光探针的设计与开发,主持,5万,2017.01-2018.12

5.河南师范大学青年科学基金,编号:5101039170302,新型免疫调节剂α-GalCer三氮唑类模拟物的设计、合成及活性研究,主持,3万,2017.01-2019.01

6.国家自然科学青年基金,编号:21702050饱和环状叔胺的C-N键氧化断裂与重组及其在官能团化环胺衍生物合成中的应用。第三参与人,25万,2018.01-2020.12

7.国家自然科学面上基金,编号:21772032N-芳基酰胺类惰性C(aryl)-N键直接活化/官能团化研究,第二参与人64万,2018.01-2021.12

8.国家自然科学基金面上项目,编号:21977025,含三氮唑模块的环二核苷酸类似物的设计合成与免疫活性研究,第二参与人2020.1-2023.12, 66万元,

9.国家自然科学基金面上项目,编号:21877026,基于前药策略的人造TPT3-NaM碱基核苷酸跨膜转运系统的构建及活性研究,第四参与人,2019.1-2022.12, 67万元,

10.河南省自然科学基金162300410180吡咯/呋喃/吡喃并喹啉类化合物的设计、合成与抗菌活性研究,第三参与人,2016.1-2020.12, 10万元,

11.河南师范大学优秀青年科学基金,编号:20180675,环胺类化合物的官能团化反应及其在具有生物活性杂环化合物合成中的应用, 第三参与人,2018.1-2021.12, 15万元,

 

12.国家自然科学基金面上项目,编号:21272057,单芳基双C-H官能化策略在苯[d]杂环衍生物合成中的应用2013.1-2016.12, 80万元, 参与人

13.国家自然科学基金面上项目,编号:21172056手性羟烷基蒽醌糖苷的设计、合成及生物活性研究2012.1-2015.12, 60万元, 参与人



代表性论文:

22. Ma Weiwei; Bi Jingjing*; Wu Hao; Zhang Guisheng*. An Intrinsic Aggregation-Induced-Emissive and Tumor-Targeting Amphiphilic Micromolecule Self-Assembles

 into Vesicles for Visualized and Targeted Drug Delivery.  ACS Med. Chem. Lett. 2020, acceptedSCI二区,IF = 3.7

21. Ma Weiwei; Bi Jingjing*; Zhao Chuanfang; Zhang Zhiguo; Liu Tongxin; Zhang Guisheng*; Synthesis and biological activities of amino acids functionalized α-GalCer

 analogues, Bioorganic & Medicinal Chemistry, Doi: 10.1016/j.bmc.2019.115141(通讯作者,SCI三区,IF = 2.8).

20. Ma Weiwei; Bi Jingjing*; Zhao Chuanfang; Gao Yangguang; Zhang Guisheng*; Design, synthesis and biological evaluation of acridone glycosides as selective BChE

inhibitors, Carbohydrate  Research, doi.org/10.1016/j.carres.2020.107977SCI四区,IF = 2.0.

19. Yanwei Chi, Zhiying Wang, Jie Wang, Wenpei Dong, Pengyang Xin, Jingjing Bi, Tao Jiang*, Chang-Po Chen*, Dimeric camptothecin-loaded mPEG-PCL nanoparticles

 with high drug loading and reduction-responsive drug release. Coloid and Polyer Science, 2020, 298, 51–58.

18. 毕晶晶,梁榕,时蕾,张贵生*,陈长坡*,新型萘-乙烯基醚类Hg2+荧光探针的合成及细胞成像研究,分析试验室,20183712:1375-1379

17. Mao Guo-Jiang*; Liang Zhen-Zhen; Bi Jingjing; Zhang Hua*; Meng Hong-Min; Su Li; Gong Yi-Jun; Feng Suling; Zhang Guisheng*.A near-infrared fluorescent probe

based on photostable Si-rhodamine for imaging hypochlorous acid during lysosome-involved inflammatory response. Analytica Chimica Acta, 2019, 1048, 143-153.

DOI: 10.1016/j.aca.2018.10.01416.

16.Bi Jingjing; Li Linlin; Ma Nana; Xia Dingding; Zhang Hua; Zhang Zhiguo; Liu Tongxin; Zhang Guisheng*. Novel Anthraquinone-based Fluorescent Probes for Detection

 of Silver Ion , Density Functional Theory and Living Cells Imaging, Chinese Journal of Analytical Chemistry, 2019, 47(2): 198-206.

15. Gao Yangguang*; Cao Zhou; Zhang Qiang; Guo Rui; Ding Fei; You, Qingliang; Bi Jingjing; Zhang Yongmin*. Total Synthesis of the Proposed Structure of Penasulfate

 A: L-Arabinose as a Source of Chirality. J Nat. Prod., 2019, 82, (7), 1908-1916. DOI: 10.1021/acs.jnatprod.9b00245

14. Wan Yameng; Zhang Zhiguo; Ma Nana; Bi Jingjing; Zhang Guisheng. Acylamino-Directed Specific Sequential Difunctionalizations of Anilides via Metal-Free Relay

 Reactions for p-Oxygen and o-Nitrogen Incorporation. J Org. Chem., 2019, 84(2), 780-791. DOI: 10.1021/acs.joc.8b02636.

13. Hu Beibei; Liu Tong-Xin; Zhang Pengling; Liu Qingfeng; Bi Jingjing; Shi Lei; Zhang Zhiguo; Zhang Guisheng. N-Heterocyclic Carbene-Catalyzed alpha,beta-Unsaturated

 Aldehydes Umpolung in Fullerene Chemistry: Construction of [60]Fullerene-Fused Cyclopentan-1-ones and Cyclohex-2-en-1-ones.Org. Lett., 2018, 20(16), 4801-4805.

DOI: 10.1021/acs.orglett.8b01956

12. Shi Lei; Xu Jingjing;Bi Jingjing; Zhang Zhiguo; Liu Tongxin; Yang Xiaolan; Zhang Guisheng. Synthesis and Biological Activity of Benzo[h]quinolinium Hydrazine

Compounds. Chinese Journal of Organic Chemistry, 2018, 38(11), 3016-3025. DOI: 10.6023/cjoc201805038.

11. Zhang Zhiguo; Zheng Dan; Wan Yameng; Zhang Guisheng; Bi Jingjing; Liu Qingfeng; Liu Tongxin; Shi Lei. Selective Cleavage of Inert Aryl C-N Bonds in N-Aryl

Amides. J Org. Chem., 2018, 83(3), 1369-1376. DOI: 10.1021/acs.joc.7b02880

10. Tong-Xin Liu,* Shaoshuai Hua, Nana Ma, Pengling Zhang, Jingjing Bi, Zhiguo Zhang, Guisheng Zhang*. Reactivity and Synthetic Applications of α-Functionalized

Oxime Acetates: Divergent Access to Fulleropyrrolidines and Mono- and Disubstituted 1-Fulleropyrrolines via Copper-Catalyzed Redox-Neutral N-Heteroannulation with

 [60]Fullerene. Adv. Synth. Catal., 2018, 360(1), 142-152.

9. 时蕾,鹿泽华,龚毅君,毕晶晶,麻娜娜,徐晶晶,张贵生*. 新罗丹明酰胺基硫脲荧光探针在水溶液中对Hg 2+ 的识别分析实验室,201736(12), 1365-1370.

8. Zhang Zhiguo*; Zheng Dan; Ma Nana; Bi Jingjing. Bronsted Acid-Promoted the Synthesis of Furo[2,3-b]quinolines. Chin. J. Org. Chem. 2017, 37(7), 1824-1829.

7. Zhiguo Zhang*, Xiaolong Gao, Haifeng Yu,Jingjing Bi, Guisheng Zhang*. Tandem Oxidative α-Hydroxylation/β-Acetalization Reaction of β-Ketoamides and Its

Applications. ACS Omega, 2017,2(11), 7746–7754.

6. Yueyang Liu, Zhiguo Zhang*, Yameng Wan, Guisheng Zhang*, Zhonglian Li, Jingjing Bi, Nana Ma, Tongxin Liu, Qingfeng Liu.Oxidation of beta-Ketoamides:

The Synthesis of Vicinal Tricarbonyl Amides. J. Org. Chem., 2017, 82 (7), 3901–3907.

5. Jingjing Bi, Jing Wang, Kai Zhou, Yuancheng Wang, Min Fang*, Yuguo Du*. Synthesis and biological activities of 5-Thio-α-GalCers. ACS Med. Chem. Lett.

 2015, 6, 476–480SCI二区,IF = 3.7.

4. Jingjing Bi, Chaoli Zhang, Qiuli Shan, Yuguo Du*. Synthesis of C3- symmetric S-linked trimannose: binding ability to concanavalin A. Carbohydr. Res.,

 2015, 412, 56-65SCI四区,IF = 2.0.
 3. Jun Liu*, Xing Zhang, Yi Liu, Jingjing Bi, Yuguo Du *. Total Synthesis of (-)-isoaltholactone. Sci. China, Ser. B, 2013, 56, 928–932.
 2. Zhiguo Zhang*, Jingjing Bi, Qingfeng Liu, Guisheng Zhang*. The synthesis of α,α-di
uoroacetamides via electrophilic uorination in the mixed-solvent of water

 and PEG-400. J. Fluorine Chem., 2013, 151, 45–49SCI四区,IF = 2.0.

1. Jingjing Bi, Zhiguo Zhang*, Qingfeng Liu, Guisheng Zhang*. Catalyst-free and High Selective Electrophilic Mono-fluorination of Acetoacetamides: Facile and

Efficient Preparation of 2-Fluoro Acetoacetamides in PEG-400. Green Chem., 2012, 14, 1159-1162. (SCI一区,IF = 9.4).

专利:

1. 具有抗癌活性的蝴蝶霉素类似物及合成方法。2013.2,中国,ZL 201010569632.

2. 具有血凝活性的硫代甘露三糖及其簇合物的合成。2014.9,中国,201410465566.1

3. 具有抗肿瘤活性的KRN7000类似物及合成方法。2014.9,中国,201410453210.6  

4.  具有免疫活性的α-GalCer磷酸酯类化合物及其合成方法2017.08,中国,201710718701.2

5. 一类具有环状结构的蒽醌糖缀合物及其制备方法和在环境检测中的应用2017.03,中国,201710127441.1

6. 不对称双-1,2,3-三氮唑类化合物及其制备方法和应用2017.08,中国,201710718659.4



 

 


 

 

 























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