个人简介：

申聪聪，1989出生，河南洛阳人，博士，讲师，

E-mail：shencongcong@htu.edu.cn

教育经历：

2008.09—2012.06   商丘师范学院   化学   理学学士

2012.09—2015.06   中南大学       分析化学   理学硕士

2015.09—2018.11   中南大学      分析化学    理学博士

主讲课程：

分析化学、仪器分析、分析化学实验、仪器分析实验、药物化学实验等。

研究领域与方向：

纳米新材料的合成，荧光纳米探针的设计及生物成像；

新型电化学生物传感体系的构建，并用于体内特定酶、糖蛋白、循环肿瘤细胞等癌症标志物的检测。

主持的科研项目：

1、河南省科技攻关项目：新型循环肿瘤细胞（CTC）电化学传感体系的构建及其在临床早筛液体活检中的应用（10.00万，项目编号：202102310139，2020.1-2021.12，在研）

2、河南师范大学博士科研启动费支持课题：基于DNA产生电流技术构建电化学细胞传感器用于乳腺癌循环肿瘤细胞的检测（8.00万，2020.1-2022.12，在研）

3、河南师范大学国家级青年科学基金培育项目（4.00万，在研）

4、湖南省博士研究生科研创新项目：基于上转换纳米颗粒光解药物缓释用于乳腺癌治疗（3.00万，项目编号：CX2016B039），已结题。

代表性成果：

<文章>

[1] Congcong Shen, Shuping Liu, Xiaoqing Li, and Minghui Yang*. Electrochemical Detection of Circulating Tumor Cells Based on DNA Generated Electrochemical Current and Rolling Circle Amplification. Analytical Chemistry, 2019, (91): 11614-11619. (IF=6.042)

[2] Congcong Shen, Ke Zeng, Junjun Luo, Xiaoqing Li, Minghui Yang*, and Avraham Rasooly*. Self-Assembled DNA Generated Electric Current Biosensor for HER2 Analysis [J]. Analytical Chemistry, 2017, 89(19): 10264-10269. (IF=6.042)

[3] Congcong Shen, Xiaodong Xia, Shengqiang Hu, Minghui Yang, and Jianxiu Wang. Silver nanoclusters-based fluorescence assay of protein kinase activity and its inhibitors. Analytical Chemistry, 2015, (87): 693-698. (IF=6.042)

[4] Congcong Shen, Xiangzhi Li, Avraham Rasooly, Linyan Guo, Kaina Zhang, Minghui Yang. A Single Electrochemical Biosensor for Detecting the Activity of Both Protein Kinase and Alkaline Phosphatase Based on Phosphate Ions Induced Deposition of Redox Precipitates. Biosensors and Bioelectronics, 2016, (85), 220-225. (IF=7.476)

[5] Congcong Shen^#, Juan Su^#, Xiangzhi Li, Junjun Luo, Minghui Yang. Electrochemical sensing platform based on Pd-Au bimetallic clusters for non-enzymatic detection of glucose. Sensors and Actuators, B chemical, 2015，(209): 695-700. (IF=5.667)

[6] Congcong Shen^#, Kaina Zhang^#, Nanxing Gao, Shijiong Wei, Guimei Liu, Yuanlin Chai, Minghui Yang*. Dual Modes of Colorimetric and Electrochemical Sensor for Detecting the Activity of Protein Kinase Based on Silver Enhancement Signal Amplification. Microchimica Acta. 2016 183:2933–2939 (IF=5.705）

[7] Congcong Shen^#, Shuping Liu^#, Xiaoqing Li, Dan Zhao, Minghui Yang*，Immunoelectrochemical detection of HER2 with gold nanoparticle-based rolling circle amplification. Microchim Acta. 2018 185:574-581 (IF=5.705）

[8] 申聪聪，阳明辉。蛋白激酶活性及抑制性检测研究进展，化学传感器。2015, 35 (1):49-57

[9] Xiaoqing Li, Congcong Shen, Minghui Yang,*and Avraham Rasooly*, Polycytosine DNA Electric-Current-Generated Immunosensor for Electrochemical Detection of Human Epidermal Growth Factor Receptor 2 (HER2). Analytical Chemistry, 2018, 90(7): 4764-4769. (IF=6.042)

[10] Lanshuang Hu, Shengqiang Hu, Linyan Guo, Congcong Shen, Minghui Yang,*and Avraham Rasooly*. DNA Generated Electric Current Biosensor. Analytical Chemistry, 2017, 89(4): 2547-2552. (IF=6.042)

[11] Yuxin Li, Congcong Shen, Xiaoqing Li, Minghui Yang*, and Chunshen Shao*. Hydroxyapatite nanoparticle based fluorometic determination and imaging of cysteine and homocysteine in living cells. Microchim Acta, 2018, 185(5):271-278. (IF=5.705）

[12] Kaina Zhang, Ke Zeng, Congcong Shen, Shiyu Tian, Minghui Yang*, Determination of protein kinase A activity and inhibition by using hydroxyapatite nanoparticles as a fluorescent probe. Microchim Acta, 2018, 185(4):225-232. (IF=5.705）

[13] Yuxin Li, Xiaoqing Li, Dan Wang, Congcong Shen, Minghui Yang, Hydroxyaptite nanoparticle based fluorometric turn-on determination of dipicolinic acid, a biomarker of bacterial spores. Microchim Acta, 2018 185: 2978-2982. (IF=5.705）

[14] Ke Zeng, Shiyu Tian, Zixiao Wang, Congcong Shen, Junjun Luo, Minghui Yang, You-Nian Liu, An ELISA for the determination of human IgG based on the formation of a colored iron(II) complex and photometric or visual read-out. Microchim Acta, 2017 184: 2791-2796. (IF=5.705）

[15] Luo Junjun, Avraham Rasooly,Wang Liqiang, Zeng Ke, Shen Congcong, Minghui Yang. Fluorescent turn-on determination of the activity of peptidases using peptide templated gold nanoclusters. Microchimica Acta, 2016,183(2): 605-610. (IF=5.705）

[16] Songbai Zhang, Xia Hu, Hongen Geng, Meixin Huang, Yangqing Qiu, Congcong Shen, Shuo Wang, Guangyu Shen, Minghui Yang, A highly sensitive and signal –on electrochemical aptasensor based on restriction endonuclease induced background elimination. Journal of the Electrochemical Society. 2016 163(8): B411-B416. (IF=3.48)

[17] Qingjun Guo, Xiangzhi Li , Congcong Shen ,Song bai Zhang, Haizhi Qi, Ting Li, Minghui Yang. Electrochemical immunoassay for the protein biomarker mucin 1 and for MCF-7 cancer cells based on signal enhancement by silver nanoclusters. Microchim Acta, 2015,182(7-8):1483-1489. (IF=5.705）

[18] Miao Zhou, Zhifang Sun, Congcong Shen, Zhengyuan Li, Yi Zhang , Minghui Yang. Application of hydrogel prepared from ferrocene functionalized amino acid in the design of novel electrochemical immunosensing platform. Biosensors and Bioelectronics, 2013, (49): 243-248. (IF=7.476)

<专利>

[1] 阳明辉，申聪聪，一种测定蛋白激酶活性的方法和蛋白激酶抑制剂活性的方法，已授权，专利号：ZL 201610058928.4

[2] 阳明辉， 申聪聪，张凯娜，一种基于比色法或电化学法测定蛋白激酶PKA的活性的方法，已授权，专利号：ZL 2016 1 0552292.9

[3] 阳明辉， 申聪聪，基于DNA产生电信号及自组装放大信号的电化学适配体传感器测定HER2的方法，已授权，专利号：ZL 2017 1 0091611.5

获奖情况                                                                                       

（1）2016年获得“中南大学拔尖博士校长奖学金”。

（2）2017年获得中南大学优秀硕士学位论文。

（3）2017年获得湖南省优秀硕士学位论文。