一、教育经历

2003.07--2006.01美国俄亥俄州立大学生物学院生物化学系，高级研究员

2003.01--2003.07美国俄亥俄州立大学生物学院生物化学系，博士后研究员

1999.09--2002.07北京大学药学院，药物化学专业，博士

1986.09--1989.07吉林大学理论化学研究所，物理化学专业,硕士

1982.09--1986.07吉林大学化学系，有机化学专业，学士

二、工作经历

2020.09-至今河南师范大学化学化工学院教授，博士生导师

2018.09-2020.09河南师范大学化学化工学院教授，博士生导师，研究生院院长

2012.07-2018.08河南师范大学化学化工学院教授、院长，省级特聘教授/博士生导师

1999.11-2012.07河南师范大学化学与环境科学学院教授，特聘教授/博士生导师

1994.11-1999.11河南师范大学化学与环境科学学院副教授

1992.07-1994.11河南师范大学化学与环境科学学院讲师

1989.07-1992.07河南师范大学化学与环境科学学院助教  

三、荣誉奖项

2013年国务院特殊津贴专家

2012年全国优秀科技工作者

2011《有机合成化学》河南省双语教学示范精品课程

2009年河南省劳动模范（先进工作者）

2008年河南省优秀专家

2005年河南省学术技术带头人

四、教学科研

        教学：主要承担本科生的《有机合成化学》和研究生的《糖及核苷化学》、《有机药物化学专论》教学工作；目前研究方向含糖药物的新药设计与合成；有机合成及绿色合成化学；药物研发及药物生产新工艺研究。

科研：主要从事含糖药物的新药设计与合成，有机合成及绿色合成化学。迄今为止，在J. Am. Chem. Soc., ACS Catal., Green Chem., Adv. Synth. Catal., J. Med. Chem., Org. Lett., Chem. Commun., J. Org. Chem.等国际SCI源期刊上发表学术论文200余篇 (论文被引用2500余次)，以第一发明人授权美国发明专利和国际发明专利各1项，中国授权发明专利15项。

五、研究领域

1.含糖药物的新药设计与合成

2.有机合成化学，绿色有机合成

3.药物研发和药物生产新工艺研究

六、联系方式

电话：0373-3325250   

E-mail：zgs6668@yahoo.com  or  zgs@htu.edu.cn

七、主持省级以上科研项目 

1.2026.01-2029.12国家自然科学基金面上项目：全新母核有机可见光催化剂设计、合成及催化性能研究（22578102）

2.2023.01-2026.12国家自然科学基金面上项目：镍/可见光催化剂协同催化的高效C-糖基化新方法（22277021）

2.2019.01-2022.12河南省高层次人才特殊支持“中原千人计划”中原领军人才：新型药物等有机功能分子的设计、合成、结构与性能研究

3.2017.01-2020.12国家自然科学基金（联合）重点项目：2’,3’-环鸟苷腺苷酸类似物的设计、合成与构效关系研究(U1604285)

4.2019.01-2022.12国家自然科学基金面上项目：基于前药策略的人造TPT3-NaM碱基核苷酸跨膜转运系统的构建及活性研究(21877026)

5.2014.01-2017.12国家自然科学基金面上项目：蒽醌并三（咪）唑核苷类似物的设计、合成及生物活性研究(21372065)

6.2012.01-2015.12国家自然科学基金面上项目：手性羟烷基蒽醌糖苷的设计、合成及生物活性研究(21172056)

7.2009.01-2011.12国家自然科学基金面上项目：新型蒽环类抗肿瘤先导化合物的水溶性糖基衍生物的合成及药物活性研究(20872029)

8.2007.01-2009.12国家自然科学基金面上项目：稀有糖及蒽环类抗生素简单结构类似物的合成及抗肿瘤活性研究(20672031)

9.1996.01-1998.12国家自然科学基金面上项目:无污染稳定配体铬载体试剂的制备及应用基础研究(29577273)

10.2011.01-2013.12教育部“长江学者与创新团队发展计划”创新团队（300万）：创新药物及医药材料的设计与合成(IRT1061)

11.2014.01-2017.12教育部“长江学者与创新团队发展计划”创新团队滚动资助（300万）：创新药物及医药材料的设计与合成(IRT-14R15)

12.2013.01-2015.12河南省科技创新杰出人才计划：手性药物Plavix合成关键技术及应用（50万）

13.2008.01-2010.12河南省杰出青年计划（20万）：新型蒽环类抗癌药物的合成及药物活性研究(084100510002)

14.2008.01-2010.12河南省高校科技创新研究团队支持计划（60万）：药物分子设计、合成及活性研究(2008IRTSTHN002)

15.2007.01-2009.12河南省高校新世纪优秀人才支持计划（40万）：含糖结构的抗肿瘤、抗病毒药物的设计、合成与生物活性研究(2006HANCET-06)

八、代表性论文和专利  

2025

1.Xiaoxiao Liu, Yuan Kou, Hao Wu, Tong-Xin Liu*, Qingfeng Liu, Zhiguo Zhang*, Xingjie Zhang, Guisheng Zhang*, Inverse conjugate additions of acrylic amides and esters with F/Cl/O/N-nucleophiles and CF3+ reagents, Sci. Adv. 2025, 11, eadt2715.

2.Xiaoxiao Liu , Di Chao, Nana Ma, Qingfeng Liu , Zhiguo Zhang, Tongxin Liu, Xingjie Zhang & Guisheng Zhang, Remote difunctionalization of alkenes through a photocatalytically triggered radical clock and α-carbonyl carbocation generation, Communications Chemistry, 2025, 8, 310.

3.Xiaoxiao Liu, Di Chao, Qingfeng Liu,* Yingchao Ma, Zhiguo Zhang, Tongxin Liu, Xingjie Zhang, and Guisheng Zhang*, Photocatalyzed Three-Component Difluoroalkyl-Halogenation of Electron-Deficient Alkenes via a Halogen α-Nucleophilic Addition, Chem. Eur. J.2025, 31, e202500434.

1.     Kai Sun, Guofeng Li, Yuyang Li, Jie Yu, Qing Zhao, Zhiguo Zhang, Guisheng Zhang, Oxidative Radical Relay Functionalization for the Synthesis of Benzimidazo[2,1-a]iso-quinolin-6(5H)-ones,Adv. Synth. Catal.,2020,362, 1947-1954.

2.QingfengLiu,Tong-XinLiu,JinliangMa,GuishengZhang,Palladium-Catalyzed Three-Component Tandem Coupling-Carboannulation Reaction Leading to Polysubstituted [60]Fullerene-Fused Cyclopentanes,Org. Lett.,2020,22, 284-289.

3.  Weiwei Ma,Jingjing Bi,Chuanfang Zhao,Zhiguo Zhang,Tongxin Liu,GuishengZhang,Synthesis and biological activities of amino acids functionalized alpha-GalCer analogues,Bioorg. Med. Chem.,2020, 28,

4.  Guo-Jiang Mao,Zhen-Zhen Liang,Guang-Qi Gao,Ying-Ying Wang, Xin-Yu Guo,Li Su,Hua Zhang,Qiu-Juan Ma,Guisheng Zhang,A photostable Si-rhodamine-based near-infrared fluorescent probe for monitoring lysosomal pH during heat stroke,Anal Chim. Acta,2019,1092, 117-125.

5.Qingfeng Liu, Tong-Xin Liu, Yifei Ru, Xue Zhu,Guisheng Zhang,Palladium-catalyzed decarboxylative heterocyclizations of [60]fullerene: preparation of novel vinyl-substituted [60]fullerene-fusedtetrahydrofurans/pyrans/quinolines,Chem. Commun.,2019,55, 14498-14501.

6.  Nana Ma,Mingyue Lv,Tongxin Liu,Mengxiao Song,Yan Liu,Guisheng Zhang,Second-order nonlinear optical properties of [60]fullerene-fused dihydrocarboline derivates: a theoretical study on switch effect,J. Mater. Chem. C,2019,7, 13052-13058.

7.   Guo-Jiang Mao,Guang-Qi Gao,Zhen-Zhen Liang,Ying-Ying Wang,Li Su,Zhuo-Xi Wang,Hua Zhang, Qiu-Juan Ma,Guisheng Zhang,A mitochondria-targetable two-photon fluorescent probe with a far-red to near-infrared emission for sensing hypochlorite in biosystems,Anal Chim. Acta,2019,1081, 184-192.

8.  Zhiguo Zhang, Xiang Li,Mengmeng Song,Yameng Wang,Dan Zheng,Guisheng Zhang,Gong Chen,Selective Removal of Aminoquinoline Auxiliary by IBX Oxidation,J. Org. Chem.,2019,84, 12792-12799.

9.     Tong-Xin Liu,Juan Wei,Pengling Zhang,Yifei Ru,Jinliang Ma,Xingjie Zhang,Nana Ma, Guisheng Zhang,Copper-Catalyzed N-H/C-H Sequential Relay Oxidative Radical Carboannulation: Construction of Diversely Substituted [60]Fullerene-FusedTetrahydrocyclopenta[b]indoles,Org. Lett.,2019,21, 6461-6465.

10.Anlian Zhu,Xiaofang Xing,Shilei Wang,Donghe Yuan,Gongming Zhu, Mingwei Geng,Yuanyang Guo,Guisheng Zhang,Lingjun Li,Multi-component syntheses of diverse 5-fluoroalkyl-1,2,3-triazoles facilitated by air oxidation and copper catalysis,Green Chem.,2019,21, 3407-3412.

11.Qingfeng Liu,Tong-Xin Liu,Nana Ma,Chenhao Tu,Ruoya Wang,Guisheng Zhang,Cu(II)/Mn(III)-Promoted Synergistic Radical N-Heteroannulation Reaction: Synthesis of [60]Fullerene-Fused Tetrahydroquinoline Derivatives,J. Org. Chem.,2019,84, 7255-7264.

12.Zhiguo Zhang,Songnan Wang,Yong Zhang,Guisheng Zhang,Regiospecific Cleavage of S-N Bonds in Sulfonyl Azides: Sulfonyl Donors,J. Org. Chem.,2019,84, 3919-3926.

13.   Xiaopeng Zhang, Zhengwei Li, Qianqian Ding,Xiaochuan Li,Xuesen Fan, Guisheng Zhang,Alkylamino-Directed One-Pot Reaction of N-Alkyl Anilines with CO, Amines and Aldehydes Leading to 2,3-Dihydroquinazolin-4(1H)-ones,Adv. Synth. Catal.,2019,361, 976-982.

14.Guo-Jiang Mao,Zhen-Zhen Liang,Jingjing Bi,Hua Zhang,Hong-Min Meng,Li Su,Yi-Jun Gong,Suling Feng,Guisheng Zhang,A near-infrared fluorescent probe based on photostable Si-rhodamine for imaging hypochlorous acid during lysosome-involved inflammatoryresponse,Anal Chim. Acta,2019,1048, 143-153.

15.Yameng Wan,Zhiguo Zhang,Nana Ma,Jingjing Bi,Guisheng Zhang,Acylamino-Directed Specific Sequential Difunctionalizations of Anilides via Metal-Free Relay Reactions for p-Oxygen and o-Nitrogen Incorporation,J. Org. Chem.,2019,84, 780-791.

16.Tong-Xin Liu,Shuaishuai Yue,Changgeng Wei,Nana Ma,Pengling Zhang,Qingfeng Liu,Guisheng Zhang,Solvent-promoted catalyst-free regioselective N-incorporation multicomponent domino reaction: rapid assembly of -functionalized [60]fullerene-fuseddihydrocarbolines, Chem. Commun.2018,54, 13331-13334.

17.Lei Shi, Jingjing Xu, Jingjing Bi, Zhiguo Zhang, Tongxin Liu, Xiaolan Yang, Guisheng Zhang,Synthesis and Biological Activity of Benzo[h]quinolinium Hydrazine Compounds,Chinese J. Org. Chem.,2018,38, 3016-3025.

18.Nana Ma,Changgeng Wei,Shujun Li,Guisheng Zhang,Theoretical insight on ethylene polymerization catalyzed by carborane-containing metal complexes: the role of carborane,Dalton T.,2018,47, 14421-14425.

19.Lingjun Li,Shenlong Huang,Tongpeng Shang,Bo Zhang,Yuanyang Guo,Gongming Zhu,Demin Zhou,Guisheng Zhang,Anlian Zhu,Lihe Zhang,Medium Rings Bearing Bitriazolyls: Easily Accessible Structures with Superior Performance as Cu Catalyst Ligands,J. Org. Chem.,2018,83, 13166-13177.

20.Hao Wu,Zhiguo Zhang,Nana Ma,Qingfeng Liu,Tongxin Liu, Guisheng Zhang,Synthesis of Acridines from o-Aminoaryl Ketones and Arylboronic Acids by Copper Trifluoroacetate-Mediated Relay Reactions,J. Org. Chem.,2018,83, 12880-12886.

21.Zhiguo Zhang,Xiaolong Gao,Haifeng Yu,Guisheng ZhangJianming Liu,Copper-Catalysed (Diacetoxyiodo)benzene-Promoted Aerobic Esterification Reaction: Synthesis of Oxamates from Acetoacetamides,Adv. Synth. Catal.,2018,360, 3406-3411.

22.Beibei Hu,Tong-Xin Liu,Pengling Zhang,Qingfeng Liu,Jingjing Bi,Lei Shi,Zhiguo Zhang,Guisheng Zhang,N-Heterocyclic Carbene-Catalyzed alpha,beta-Unsaturated Aldehydes Umpolung in Fullerene Chemistry: Construction of [60]Fullerene-FusedCyclopentan-1-ones and Cyclohex-2-en-1-ones,Org. Lett.2018,20, 4801-4805.

23.Ning Lu,Zhiguo Zhang,Nana Ma,Conghui Wu,Guisheng Zhang, QngfengLiu,Tongxin Liu,Copper-Catalyzed Difunctionalization of Allenes with Sulfonyl Iodides Leading to (E)-alpha-lodomethyl Vinylsulfones,Org. Lett.2018,20, 4318-4322.

24.Hao Wu,Zhiguo Zhang,Qingfeng Liu,Tongxin Liu,Nana Ma, Guisheng Zhang,Syntheses of Acridones via Copper(II)-Mediated Relay Reactions from o-Aminoacetophenones and Arylboronic Acids,Org. Lett.2018,20, 2897-2901.

25.Nana Ma,Jinjin Gong,Jie Zhang,Shangning Han,Mengxiao Song,Guisheng Zhang,Theoretical Exploration of the Layered Sandwich Cobaltacarborane as a Multi-State NLO Molecular Switch Triggered by Redox,J. Phys. Chem. C,2018,122, 6818-6825.

26.Zhiguo Zhang,Dan Zheng,Yameng Wan,Guisheng Zhang,Jingjing Bi,Qingfeng Liu,Tongxin Liu, Lei Shi,Selective Cleavage of Inert Aryl C-N Bonds in N-Aryl Amides,J. Org. Chem.2018,83, 1369-1376.

27.Shilu Xia,Tong-Xin Liu,Pengling Zhang,Jinliang Ma,Qingfeng Liu,Nana Ma,Zhiguo Zhang,Guisheng Zhang,Broad Synthesis of Disubstituted Dihydrofuran-Fused [60]Fullerene Derivatives via Cu(I)/Ag(I)-Mediated Synergistic Annulation Reaction,J. Org. Chem.2018,83, 862-870.

28.Tong-Xin Liu,Shaoshuai Hua,Nana Ma,Pengling Zhang,Jingjing Bi,Zhiguo Zhang,Guisheng Zhang,Reactivity and Synthetic Applications of alpha-Functionalized Oxime Acetates: Divergent Access to Fulleropyrrolidines and Mono- and Disubstituted 1-Fulleropyrrolines via Copper-Catalyzed Redox-Neutral N-Heteroannulation with [60]Fullerene,Adv. Synth. Catal.,2018,360, 142-152.

29.Yan Yan, Zhiguo Zhang,Yameng Wan,Guisheng Zhang,Nana Ma,Qingfeng Liu,Hypervalent Iodine(III)-Promoted Phenyl Transfer Reaction from Phenyl Hydrazides to Nitriles,J. Org. Chem.2017,82, 7957-7963.

30.Lingjun Li,Qianqian Li,Shengqiang Ding,Pengyang Xin,Yuqin Zhang,Shenlong Huang, Guisheng Zhang, ADP-ribosyl-N-3: A Versatile Precursor for Divergent Syntheses of ADP-ribosylated Compounds,Molecules,2017, 22, 1346.

31.Zhiguo Zhang,Yongchao Zhang,Guoqing Huang,Guisheng Zhang,Organoiodine reagent-promoted intermolecular oxidative amination: synthesis of cyclopropyl spirooxindoles,Org. Chem. Front.,2017,4, 1372-1375.

32.Xuna Zhao,Tong-Xin Liu,Nana Ma,Guisheng Zhang,In Situ Generated TEMPO Oxoammonium Salt Mediated Tandem Cyclization of beta-Oxoamides with Amine Hydrochlorides for the Synthesis ofPyrrolin-4-ones,J. Org. Chem.2017,82, 6125-6132.

33.Yueyang Liu,Zhiguo Zhang,Yameng Wan,Guisheng Zhang,Zhonglian Li,Jingjing Bi, Nana Ma, Tongxin Liu, Qingfeng Liu, Oxidation of beta-Ketoamides: The Synthesis of Vicinal Tricarbonyl Amides,J. Org. Chem.,2017,82, 3901-3907.

34.Xin Wan,Kai Sun,Guisheng Zhang,Metal-free tetra-n-butylammonium bromide-mediated aerobic oxidative synthesis of beta-ketosulfones from styrenes,Sci. China Chem.,2017,60, 353-357.

35.Zhiguo Zhang,Xiaolong Gao,Zhonglian Li,Guisheng Zhang,Nana Ma,Qingfeng Liu, Tongxin Liu, PIFA-Mediated oxidative cyclization of 1-aroyl-N-arylcyclopropane-1-carboxamides and their application in the synthesis of pyrrolo[3,2-c]quinolinones,Org. Chem. Front.,2017,4, 404-408.

36.Nana Ma,Jinjin Gong,Shujun Li,Jie Zhang,Yongqing Qiu,Guisheng Zhang,Second-order NLO responses of two-cavity inorganic electrides Li-n@B20H26 (n=1, 2): evolutions with increasing excess electron number and variousB-B connection sites of B20H26,Phys. Chem. Chem. Phys.,2017,19, 2557-2566.

37.Lingjun Li,Shengqiang Ding,Yanping Yang,Anlian Zhu,Xincui Fan,Mengchao Cui,Changpo Chen,Guisheng Zhang,Multicomponent Aqueous Synthesis of Iodo-1,2,3-triazoles: Single-Step Models for Dual Modification of Free Peptide and Radioactive Iodo Labeling,Chem. Eur. J.,2017,23, 1166-1172.

38.Xiaopeng Zhang,Shuxiang Dong,Xueli Niu,Zhengwei Li, Xuesen Fan, Guisheng Zhang,Palladium-Catalyzed Ortho-Selective C-H Oxidative Carbonylation of N-Substituted Anilines with CO and Primary Amines for the Synthesis of o-Aminobenzamides,Org. Lett.,2016,18, 4634-4637.

39.Tong-Xin Liu, Jinliang Ma,Di Chao,Pengling Zhang,Nana Ma, Qingfeng Liu,Lei Shi,Zhiguo Zhang,Guisheng Zhang,Synthesis of C-60-Fused Tetrahydrocarbazole/Dibenzothiophene/Benzothiophene and Dibenzofuran Derivatives via Metal-Free OxidativeDehydrogenative Carboannulation,Org. Lett.,2016,18, 4044-4047.

40.Zhiguo Zhang,Jingjing Qian,Guisheng Zhang,Nana Ma,Qingfeng Liu,Tongxin Liu,Kai Sun,Lei Shi,Copper(I) catalyzed C(sp(2))-N bond formation: synthesis of pyrrolo[3,2-c]quinolinone derivatives,Org. Chem. Front.,2016,3, 344-348.

41.Yi-Jun Gong,Xiao-Bing Zhang,Guo-Jiang Mao,Li Su,Hong-Min Meng,Weihong Tan,Suling Feng,Guisheng Zhang,A unique approach toward near-infrared fluorescent probes for bioimaging with remarkably enhanced contrast,Chem. Sci.,2016,7, 2275-2285.

42.Di Chao,Tong-Xin Liu,Nana Ma,Pengling Zhang,Zheng Fu,Jinliang Ma,Qingfeng Liu, FengjinZhang,Zhiguo Zhang,Guisheng Zhang,Silver(I)-mediated three-component annulation reaction of [60]fullerene, sulfonylhydrazones, and nitriles: leading to diverse disubstituted[60]fullerene-fused dihydropyrroles,Chem. Commun.,2016,52, 982-985.

43.Kai Sun,Xin Wang,Lulu Liu,Jingjing Sun,Xin Liu,Zhenduo Li,Zhiguo Zhang, Guisheng Zhang,Copper-Catalyzed Cross-Dehydrogenative C-N Bond Formation of Azines with Azoles: Overcoming the Limitation of Oxidizing N-O Activation Strategy,ACS Catal.,2015,5, 7194-7198.

44.Zhiguo Zhang,Feisong Zhang,Huanhuan Wang,Hao Wu,Xinyu Duan,Qingfeng Liu,Tongxin Liu,Guisheng Zhang, Catalyst-Free Domino Reaction of 1-Acryloyl-1-N-arylcarbamyl-cyclopropanes with Amines: One-Pot Approach to 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones,Adv. Synth. Catal.,2015,357, 2681-2686.

45.Zhiguo Zhang,Junlong Li,Guisheng Zhang,Nana Ma,Qingfeng Liu,Tongxin Liu,Iron-Catalyzed Intramolecular C(sp(2))-N Cyclization of 1-(N-Arylpyrrol-2-yl)ethanone O-Acetyl Oximes toward Pyrrolo[1,2-a]quinoxaline Derivatives,J. Org. Chem.,2015,80, 6875-6884.

46.Tong-Xin Liu,Jinliang Ma,Di Chao,Pengling Zhang,Qingfeng Liu,Lei Shi, Zhiguo Zhang, Guisheng Zhang,AgNO2-mediated cleavage of the N-N bond of sulfonylhydrazones and oxygen transfer: access to fulleroisoxazolines via radical cyclization with[60]fullerene,Chem. Commun.,2015,51, 12775-12778.

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