张志国

张志国



       

张志国,博士,教授,硕士生导师。1977 年生于黑龙江省延寿县,2012 年 09 月加入九·三学社。河南省杰出青年科学基金、吉林省优秀博士学位论文获得者。先后获得河南省教育厅学术技术带头人、河南省高校科技创新人才、河南省高校青年骨干教师、河南省优秀博士后研究人员、河南师范大学平原学者等荣誉称号。《Chin Chem Lett》编委,《有机化学》青年编委,《河南师范大学学报》(自然科学版) 青年编委,《能源与环保》青年编委。

科研方面:主要从事含氮、氧等杂环类化合物的合成研究工作,尤其是天然产物母核结构的合成。先后主持国家级项目 4 项 (包括:青年基金 1 项,面上项目 2 项,国家博士后特别资助 1 项),主持省部级项目 6 项 (包括:省杰出青年科学基金项目1项,省自然科学基金面上项目1项,国家博士后面上项目1项,省高校青年骨干教师项目1项,省科技创新人才计划项目 1 项,省基础与前沿技术研究项目1项)。截止2023年09月,在Angew Chem Int Ed、Chem Sci、Green Chem、Org Lett 和 J Org Chem等国际学术期刊上发表SCI研究论文 83 篇。其中,1 个研究工作被国际新药研发企业“药明康德”作为工具方法收录;2 个研究工作入选SCI高被引论文;3 个研究工作被评论性期刊Synfacts杂志以亮点文章评价并推介;6 个研究工作被有机化学专业网站http://www.organic-chemistry.org/作为工具方法永久收录并推介。获得河南省优秀科技论文一等奖1项二等奖2项,河南省自然科学论文一等奖 2  项。授权中国发明专利  12  件。受邀担任30余种SCI期刊的审稿人。

教学方面:主要承担本科生《有机化学实验》和研究生《现代化学实验技术》课程教学,也是“《有机合成化学》河南省高等学校双语教学示范课程”和“《金属有机化学》河南省高等学校双语教学示范课程”的主要成员。

热烈欢迎广大有志从事有机化学的同学加盟,一起用有机化学改变人生,开创美好的明天!

联系电话:18951893592

E-mail:zhangzg@htu.edu.cn16009297@qq.com

实验室地址:河南师范大学西校区化学北楼N-608实验室(你来或不来我都在这里等你!)


教育与研究经历:

1994年09月 – 1998年07月       黑龙江省延寿县第一中学94-6班。

1998年09月 – 2002年07月      牡丹江师范学院化学系,理学学士。

2002年09月 – 2004年08月      河北怀安第一高级中学,化学教师。

2004年09月 – 2010年06月      东北师范大学化学学院,硕博连读,理学博士。

2010年07月 – 2013年10月     河南师范大学,化学与化工学院,教师,讲师。

2012年02月 – 2014年12月     河南师范大学,化学博士后科研流动站,博士后。

2013年11月 – 2022年10月    河南师范大学,化学与化工学院,教师,副教授。

2022年11月 – 现在                河南师范大学,化学化工学院,教师,教授。


领域与兴趣:

有机合成化学;绿色合成化学;金属有机化学


主持的科研项目:


1. 国家自然科学基金项目——面上项目,N-芳基酰胺类惰性C(aryl)-N键直接活化/官能化反应研究,21772032,2018.01-2021.12,64万元,主持。

2. 国家自然科学基金项目——面上项目,单芳基双C-H官能化策略在苯[d]杂环衍生物合成中的应用,21272057,2013.01-2016.12,80万元,主持。

3. 国家自然科学基金项目——青年基金项目,炔丙基全碳1,3-偶极子在构建呋喃并杂环衍生物中的应用,21002051,2011.01-2013.12,19万元,主持。

4. 河南省自然科学基金——杰出青年科学基金项目,螺环化合物不对称合成研究,222300420012,2022.01-2024.12,50万元,主持。

5. 中国博士后科学基金——特别资助项目,呋喃并杂环合成新策略研究,2013T60701,2013.06-2014.12,15万元,主持。

6. 中国博士后科学基金——面上项目,单芳基双C-H官能化新策略制备几种苯并杂环衍生物,2012M521397,2012.11-2014.12,5万元,主持。

7. 河南省自然科学基金——面上项目,吡咯/呋喃/吡喃并喹啉类化合物的设计、合成与抗菌活性研究,162300410180,2017.01-2019.12,10万元,主持。

8. 河南省教育厅科技创新人才支持计划,几种吡咯并杂环衍生物新合成策略研究,17HASTIT002,2017.01-2018.12,60万元,主持,结题优秀。

9. 河南省高等学校青年骨干教师资助计划,C(sp2)-H键活化/C(sp2)-N键形成反应在合成角型的杂环并喹啉酮类化合物中的应用,2014GGJS-049,2015.01-2018.01,4万元,主持。

10. 河南省基础与前沿技术研究项目,天然产物杂环母核合成新方法,112300410312,2011.01-2013.12,主持。

11. 东北师范大学优秀博士论文基金,几种杂环并喹啉类生物碱的新合成策略研究,2008-2010,6万元,主持。


代表性论文(第一作者或者通讯作者)

1. Zhang, Z.; Zhang, Q.;* Sun, S.; Xiong, T.; Liu, Q.* Domino Ring-Opening/Recyclization Reactions of Doubly Activated Cyclopropanes as a Strategy for the Synthesis of Furoquinoline Derivatives. Angew. Chem. Int. Ed., 2007, 46, 1726-1729. https://doi.org/10.1002/anie.200604276

2. Zhang, Z.; Zhang, Q.;* Yan, Z.; Liu, Q.* One-Step Synthesis of the Tricyclic Core of Martinellic Acid from 2-(Cyanomethyl)-3-oxo-N-arylbutanamides. J. Org. Chem., 2007, 72, 9808-9810. https://doi.org/10.1021/jo701551f

3. Zhang, Q.;* Zhang, Z.; Yan, Z.; Liu, Q.,* Wang, T. A New Efficient Synthesis of Pyranoquinolines from 1-Acetyl N-Aryl Cyclopentanecarboxamides. Org. Lett., 2007, 9, 3651-3653. https://doi.org/10.1021/ol701536q

4. Xiong, T.; Zhang, Q.;* Zhang, Z.; Liu, Q.* A Divergent Synthesis of γ-Iminolactones, Dihydroquinolin-2-ones and γ-Lactames from β-Hydroxymethylcyclopropanylamides. J. Org. Chem., 2007, 72, 8005-8009. https://doi.org/10.1021/jo701495s

5. Zhang, Z.; Zhang, Q.;* Ni, Z.; Liu, Q.* Ag-containing all-carbon 1,3-dipoles: generation and formal cycloaddition for furo[3,2-b]-β/γ-lactams. Chem. Commun., 2010, 46, 1269-1271 (Highlight by SYNFACTS, Synfacts, 2010, 5, 0524). https://doi.org/10.1039/b917856b

6. Zhang, Z.;* Xue, C., Liu, X.; Zhang, Q.;* Liu, Q.* Synthesis of polysubstituted 3H-pyrimidin-4-ones from cyanoacetamides under Vilsmeier conditions. Tetrahedron, 2011, 67, 7081-7084. https://doi.org/10.1016/j.tet.2011.07.006

7. Zhang, Z.;* Fang, S.; Liu, Q.; Zhang, G.,* Microwave-assisted facile synthesis of furo[3,2-b]indole derivatives via silver(I)-mediated [3+2] cycloaddition. Adv. Synth. Catal., 2012, 354 (5), 927-932. https://doi.org/10.1002/adsc.201100767

8. Zhang, Z.;* Fang, S.; Liu, Q.; Zhang, G.* Approach to polysubstituted 4-pyridones from N-aryl acetoacetamides via a N to C 1,3-acyl migration mediated by sodium persulfate. J. Org. Chem., 2012, 77 (17), 7665-7670. https://doi.org/10.1021/jo3010217

9. Bi, J.; Zhang, Z.;* Liu, Q.; Zhang, G.* Catalyst-free and highly selective electrophilic mono-fluorination of acetoacetamides: facile and efficient preparation of 2-fluoroacetoacetamides in PEG-400. Green Chem., 2012, 14 (4), 1159-1162. https://doi.org/10.1039/C2GC16661E


10. Zhang, Z.;* Bi, J.; Liu, Q.; Zhang, G.* The Synthesis of α,α-Difluoroacetamides via Electrophilic Fluorination in the Mixed-solvent of Water and PEG-400. J. Fluorine Chem., 2013, 151, 45-49. https://doi.org/10.1016/j.jfluchem.2013.03.016


11.Zhang, Z.;* Wang, D.; Wang, B.; Liu, Q.; Liu, T.; Zhang, W.; Yuan, B.; Zhao, Z.; Han, D.; Zhang, G.* SnCl4 Mediated synthesis of γ-amino ketones derivatives via the ring-opening reaction of 4,5-dihydropyrroles. Tetrahedron, 2013, 69, 9063. https://doi.org/10.1016/j.tet.2013.08.027

12. Li, Z.; Zhang, Z.;* Zhang, W.; Liu, Q.; Liu, T.; Zhang, G.* Copper-Mediated Sequential C-N and N-N Bond Formation: Facile Synthesis of Symmetrical 1,2,4-Triazoles. Synlett, 2013, 24, 2735-2739. https://doi.org/10.1055/s-0033-1338985

13. Zhang, Z.;* Qian, J.; Tain, Q.; Liu, T.; Liu, Q.; Zhang, G.* Oxidative Nuclear Bromination of Substituted 4-Pyridones Using Pyridinium Bromochromate. Synth. Commun., 2014, 44, 674-81. https://doi.org/10.1080/00397911.2013.834363

14. Zhang, Z.;* Zhang, W.; Li, J.; Liu, Q.; Liu, T.; Zhang, G.* Synthesis of Multisubstituted Pyrroles from Doubly Activated Cyclopropanes Using an Iron-Mediated Oxidation Domino Reaction. J. Org. Chem., 2014, 79, 11226–11233. https://doi.org/10.1021/jo5018487

15. Zhang, Z.;* Tian, Q.; Qian, J.; Liu, Q.; Liu, T.; Shi, L.; Zhang, G.,* Dimethyl Sulfoxide Participant Iron-Mediated Cascade Oxidation/alpha-Formylation Reaction of Substituted 2,3-Dihydropyrroles under Air and Protonic Acid Free Condition. J. Org. Chem.,2014,79, 8182-8188. https://doi.org/10.1021/jo501385w

16. Zhang, L.; Zhang, Z.;* Liu, Q.; Liu, T.; Zhang, G.* Iron-Catalyzed Vinylogous Aldol Condensation of Biginelli Products and Its Application toward Pyrido[4,3-d]pyrimidinones. J. Org. Chem., 2014, 79, 2281-2288. https://doi.org/10.1021/jo402773r

17. Qian, J.; Zhang, Z.;* Liu, Q.; Liu, T.; Zhang, G.* Dimethyl Sulfoxide Participating in Copper(I) Iodide-Catalyzed Cascade Oxidation/Formylation Reactions: The Synthesis of alpha-Formylpyrroles from 2,3-Dihydro-1H-pyrroles. Adv. Synth. Catal., 2014, 356, 3119-3124. https://doi.org/10.1002/adsc.201400332

18. Zhang, Z.;* Zhang, L.; Duan, X.; Yan, X.; Yan, Y.; Liu, Q.; Liu, T.; Zhang, G.* Iron-catalyzed four-member multicomponent reaction for assembly of (E)-6-arylvinyl-3,4-dihydropyrimidin-2(1H)-ones. Tetrahedron, 2015, 71, 7745-7751. https://doi.org/10.1016/j.tet.2015.07.039

19. Zhang, Z.;* Zhang, F.; Wang, H.; Wu, H.; Duan, X.; Liu, Q.; Liu, T.; Zhang, G.* Catalyst-Free Domino Reaction of 1-Acryloyl-1-N-arylcarbamylcyclopropanes with Amines: One-Pot Approach to 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones. Adv. Synth. Catal., 2015, 357, 2681-2686. https://doi.org/10.1002/adsc.201500251

20. Zhang, Z.;* Li, J.; Zhang, G.;* Ma, N.; Liu, Q.; Liu, T. Iron-Catalyzed Intramolecular C(sp(2))-N Cyclization of 1-(N-Arylpyrrol-2-yl)ethanone O-Acetyl Oximes toward Pyrrolo[1,2-a]quinoxaline Derivatives. J. Org. Chem., 2015, 80, 6875-6884. https://doi.org/10.1021/acs.joc.5b00915

21. Kai Sun,* Xin Wang, Lulu Liu, Jingjing Sun, Zhiguo Zhang, Guisheng Zhang*, Copper-Catalyzed Cross-Dehydrogenative C−N Bond Formation of Azines with Azoles: Overcoming the Limitation of  Oxidizing N−O Activation Strategy, ACS Catal., 2015, 5, 7194. https://pubs.acs.org/doi/10.1021/acscatal.5b02411 

22.Zhang, Z.;* Yan, X.; Zhang, G.;* Liu, Q.; Ma, N.; Liu, T.; Shi, L. Copper(I)-catalyzed domino allylic C(sp3)–H aminative cyclization/oxidative reaction and its application toward pyrrolo[3,4-d]pyrimidinones. Tetrahedron, 2016, 72, 3077-3083. https://doi.org/10.1016/j.tet.2016.04.031

23. Zhang, Z.;* Qian, J.; Zhang, G.;* Ma, N.; Liu, Q.; Liu, T.; Sun, K.; Shi, L. Copper(I) catalyzed C(sp2)–N bond formation: synthesis of pyrrolo[3,2-c]quinolinone derivatives. Org. Chem. Front., 2016, 3, 344-348. https://doi.org/10.1039/C5QO00417A


24. Zhang, Z.;* Li, J.; Huang, G.; Sun, K.; Zhang, G.;* Ma, N.; Liu, Q.; Liu, T. Copper(I)-Catalyzed Intramolecular N-N Coupling of Cyclopropyl O-Acyl Ketoximes: Synthesis of Spiro-fused Pyrazolin-5-ones. Chin. J. Chem., 2016, 34, 1309-1320. https://doi.org/10.1002/cjoc.201600479


25. Yan, X.; Zhang, Z.;* Zhang, G.;* Ma, N.; Liu, Q.; Liu, T.; Shi, L. Copper(I)-catalysed amidation and successive oxidation of benzylic C(sp3)–H bond: synthesis of 1H-pyrrolo[3,4-b]quinoline-1,3(2H)-diones. Tetrahedron, 2016, 72, 4245-4251. https://doi.org/10.1016/j.tet.2016.05.059

26. Zhang, Z.;* Zheng, D.; Ma, N.; Bi, J. Brønsted Acid-Promoted the Synthesis of Furo[2,3-b]quinolones. Chin. J. Org. Chem., 2017, 37, 1824-1829. https://doi.org/10.6023/cjoc201612032

27. Zhang, Z.;* Zhang, Y.; Huang, G.; Zhang, G.* Organoiodine reagent-promoted intermolecular oxidative amination: synthesis of cyclopropyl spirooxindoles. Org. Chem. Front., 2017, 4, 1372-1375. https://doi.org/10.1039/C7QO00156H

28. Zhang, Z.;* Huang, Y.; Huang, G.; Zhang, G.;* Liu, Q. [Bis-(trifluoroacetoxy)iodo]benzene-Mediated Oxidative Direct Amination C-N Bond Formation: Synthesis of 1H-Indazoles. J. Heterocyclic Chem., 2017, 54, 2426. https://doi.org/10.1002/jhet.2839/full

29. Zhang, Z.;* Gao, X.; Li, Z.; Zhang, G.;* Ma, N.; Liu, Q.; Liu, T. PIFA-Mediated oxidative cyclization of 1-aroyl-N-arylcyclopropane-1-carboxamides and their application in the synthesis of pyrrolo[3,2-c]quinolinones. Org. Chem. Front., 2017, 4, 404-408. https://doi.org/10.1039/C6QO00598E

30. Liu, Y.; Zhang, Z.;* Wan, Y.; Zhang, G.;* Li, Z.; Bi, J.; Ma, N.; Liu, T.; Liu, Q. Oxidation of beta-Ketoamides: The Synthesis of Vicinal Tricarbonyl Amides. J. Org. Chem., 2017, 82, 3901-3907 (Record by Organic Chemistry Portal. Please see: https://www.organic-chemistry.org/abstracts/lit5/816.shtm). https://doi.org/10.1021/acs.joc.6b03062

31. Yan, Y.; Zhang, Z.;* Wan, Y.; Zhang, G.;* Ma, N.; Liu, Q. Hypervalent Iodine(III)-Promoted Phenyl Transfer Reaction from Phenyl Hydrazides to Nitriles. J. Org. Chem., 2017, 82, 7957-7963. https://doi.org/10.1021/acs.joc.7b01215

32. Zhang, Z.;* Gao, X.; Wan, Y.; Huang, Y.; Huang, G.; Zhang, G.* Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones. ACS Omega, 2017, 2, 6844-6851. https://doi.org/10.1021/acsomega.7b00626

33.  Zhang, Z.;* Gao, X.; Yu, H.; Bi, J.; Zhang, G.* Tandem Oxidative α-Hydroxylation/β-Acetalization Reaction of β-Ketoamides and Its Applications. ACS Omega, 2017, 2, 7746-7754. https://doi.org/10.1021/acsomega.7b01526


34.  Kai Sun*, Yunhe Lv, Zuodong Shi, Fangfang Fu, Chong Zhang, Zhiguo Zhang*, Direct Access to β-Selenosulfones at Room Temperature through Selenosulfonylation of Alkene, Sci. China Chem., 2017, 60, 730. https://link.springer.com/article/10.1007/s11426-016-0412-0?utm_source=xmol&utm_medium=affiliate&utm_content=meta&utm_campaign=DDCN_1_GL01_metadata

    35. Zhang, Z.;* Zheng, D.; Wan, Y.; Zhang, G.;* Bi, J.; Liu, Q.; Liu, T.; Shi, L. Selective Cleavage of Inert Aryl C-N Bonds in N-Aryl Amides. J. Org. Chem., 2018, 83, 1369-1376 (Record by Organic Chemistry Portal. Please see: https://www.organic-chemistry.org/abstracts/lit6/197.shtm;该研究工作还被国际医药研发企业“药明康德”公众号——“实用有机合成化学”的“保护基的引入/消除”专栏收录). https://doi.org/10.1021/acs.joc.7b02880

36. Hu, C.; Zhang, Z.;* Gao, W.; Zhang, G.;* Liu, T.; Liu, Q. PIFA-promoted intramolecular oxidative C(aryl)-H amidation reaction: Synthesis of quinolino[3,4-b]quinoxalin-6(5H)-ones. Tetrahedron, 2018, 74, 665-671. https://doi.org/10.1016/j.tet.2017.12.016

37. Wu, H.; Zhang, Z.;* Ma, N.; Liu, Q.; Liu, T.; Zhang, G.* Synthesis of Acridines from O-Aminoaryl Ketones and Arylboronic Acids by Copper Trifluoroacetate-Mediated Relay Reactions. J. Org. Chem., 2018, 83, 12880-12886 (Highlight by SYNFACTS, Synfacts, 2018, 14, 1230). https://doi.org/10.1021/acs.joc.8b01828


38. Zhang, Z.;* Gao, X.; Yu, H.; Zhang, G.;* Liu, J. Copper-Catalysed (Diacetoxyiodo)benzene-Promoted Aerobic Esterification Reaction: Synthesis of Oxamates from Acetoacetamides. Adv. Synth. Catal., 2018, 360, 3406-3411. https://doi.org/10.1002/adsc.201800616

39. Wu, H.; Zhang, Z.;* Liu, Q.; Liu, T.; Ma, N.; Zhang, G.* Syntheses of Acridones via Copper(II)-Mediated Relay Reactions from O-Aminoacetophenones and Arylboronic Acids. Org. Lett., 2018, 20, 2897-2901. https://doi.org/10.1021/acs.orglett.8b00957

40. Lu, N.; Zhang, Z.;* Ma, N.; Wu, C.; Zhang, G.;* Liu, Q.; Liu, T. Copper-Catalyzed Difunctionalization of Allenes with Sulfonyl Iodides Leading to (E)-α-Iodomethyl Vinylsulfones. Org. Lett., 2018, 20, 4318 (Record by Organic Chemistry Portal. Please see: https://www.organic-chemistry.org/abstracts/lit6/423.shtm). https://doi.org/10.1021/acs.orglett.8b01765

41. Wan, Y.; Zhang, Z.;* Ma, N.; Bi, J.; Zhang, G.* Acylamino-Directed Specific Sequential Difunctionalizations of Anilides via Metal-Free Relay Reactions for p-Oxygen and o-Nitrogen Incorporation. J. Org. Chem., 2018, 84, 780-791 (Record by Organic Chemistry Portal. Please see: https://www.organic-chemistry.org/Highlights/2019/14October.shtm). https://doi.org/10.1021/acs.joc.8b02636

42. Zhang, Z.;* Wang, S.; Hu, C.; Ma, N.; Zhang, G.;* Liu, Q. Copper(I)-catalyzed benzylic C(sp3)–H geminal difunctionalization: Successive oxidative intramolecular amidation and hydroxylation. Tetrahedron, 2018, 74, 7472-7479. https://doi.org/10.1016/j.tet.2018.11.023

43. Zhang, Z.;* Li, X.; Song, M.; Wan, Y.; Zheng, D.; Zhang, G.;* Chen, G.* Selective Removal of Aminoquinoline Auxiliary by IBX Oxidation. J. Org. Chem., 2019, 84, 12792-12799 (Highlight by SYNFACTS, Synfacts, 2019, 15, 1209). https://doi.org/10.1021/acs.joc.9b01362

44. Zhang, Z.;* Wang, S.; Zhang, Y.; Zhang, G.* Regiospecific Cleavage of S-N Bonds in Sulfonyl Azides: Sulfonyl Donors. J. Org. Chem., 2019, 84, 3919-3926 (Record by Organic Chemistry Portal. Please see: https://www.organic-chemistry.org/abstracts/lit6/766.shtm). https://doi.org/10.1021/acs.joc.8b03046

45. Zhang, Z.;* Li, X.; Li, Y.; Guo, Y.; Zhao, X.; Yan, Y.; Sun, K.; Zhang, G.* Iodine-mediated aryl transfer reaction from arylhydrazine hydrochlorides to nitriles. Tetrahedron, 2019, 75, 3628-3635. https://doi.org/10.1016/j.tet.2019.05.034



46. Kai Sun,* Songnan Wang, Ranran   Feng, Yixiao Zhang, Xin Wang, Zhiguo Zhang,* Bing Zhang, Copper-Catalyzed Radical Selenodifluoromethylation of Alkenes: Access to CF2-Containing γ-Lactams, Org. Lett., 2019, 21, 2052. ( ESI高被引论文) https://pubs.acs.org/doi/10.1021/acs.orglett.9b00240


47. Sun, K.; Li, G.; Li, Y.; Yu, J.; Zhao, Q.; Zhang, Z.;* Zhang, G.* Oxidative Radical Relay Functionalization for the Synthesis of Benzimidazo[2,1-a]iso-quinolin-6(5H)-ones. Adv. Synth. Catal., 2020, 362, 1947-1954. https://doi.org/10.1002/adsc.202000040


48. Song, M.; Zhang, Z.;* Zheng, D.; Li, X.; Liang, R.; Zhao, X. N.; Shi, L.; Zhang, G.* Hypervalent Organoiodine Promoted Dearylation Reaction of N-Aryl Sulfonamides. Chin. J. Org. Chem., 2020, 40, 2433-2441. https://doi.org/10.6023/cjoc202001007

49. Gao, W.; Wan, Y.; Zhang, Z.;* Wu, H.; Liu, T.; Zhang, G.* The Hofmann reaction involving annulation of o-(pyridin-2-yl)aryl amides selectively and rapidly leads to potential photocatalytically active 6H-pyrido[1,2-c]quinazolin-6-one derivatives. Green Chem., 2020, 22, 7955-7961. https://doi.org/10.1039/d0gc02777d


50. Zhang, Z.;* Song, X.; Li, G.; Li, X.; Zheng, D.; Zhao, X.; Miao, H.; Zhang, G.* Liu, L., Synthesis of polycyclic spiro-fused indolines via IBX-mediated cascade cyclization. Chin. Chem. Lett., 2021, 32, 1423–1426. https://doi.org/10.1016/j.cclet.2020.11.001

51. Wan, Y.; Wu, H.; Ma, N.; Zhao, J.; Zhang, Z.;* Gao, W.; Zhang, G.,* De novo design and synthesis of dipyridopurinone derivatives as visible-light photocatalysts in productive guanylation reactions. Chem. Sci., 2021, 12, 15988-15997. https://doi.org/10.1039/d1sc05294b



52. Xin Wang, Sa Guo, Yan Zhang, Zhiguo Zhang,* Guisheng Zhang,* Yong Ye, Kai Sun*, Metal-Free Organoselenium-Enabled Radical Relay Azidation–Carbocyclization, Adv. Synth. Catal., 2021, 363, 3290-3296. https://onlinelibrary.wiley.com/doi/10.1002/adsc.202100208


53. Sun, K.;* Li, G.; Guo, S.; Zhang, Z.;* Zhang, G.,* Copper-catalyzed radical cascade cyclization for synthesis of CF3-containing tetracyclic benzimidazo[2,1-a]iso-quinolin-6(5H)-ones. Org. Biomol. Chem., 2021, 19, 375-378. https://doi.org/10.1039/d0ob02210a



54. 张志国;* 曹夕阳; 王港; 方世亮; 吴昊; 张贵生, 呋喃[3,2-b]吲哚类化合物碱性条件下扩环重排反应. 河南师范大学学报,2022, 50, 95-101. https://doi.org/10.16366/j.cnki.1000-2367.2022.02.012

55. Zhang, Z.;* Cao, X. Y.; Wang, G.; Zhang, G.;* Zhang, X. J., Straightforward synthesis of biologically valuable nonsymmetrical malonamides under mild conditions. Green Chem. 2022, 24, 3035-3041. https://doi.org/10.1039/d2gc00395c

56. Wan, Y.; Liu, Q.; Wu, H.; Zhang, Z.;* Zhang, G.,* 2,11-Dimethoxyldipyridopurinone as an efficient reducing visible-light photocatalyst for organic transformations. Org. Chem. Front. 2022, 9, 1634-1641. https://doi.org/10.1039/D1QO01914G


57. Sa Guo, Xin Wang, Dongyang Zhao, Zhiguo Zhang, Guisheng Zhang, Shi Tang, Kai Sun*, Convenient Access to Ester-Containing Quinolinones Through Sequential Radical Alkoxycarbonylation Cyclization Hydrolysis Process, Asian J. Org. Chem., 2022, 11, e20210081. https://doi.org/10.1002/ajoc.202100812


58. Cao, X.; Zhang, Z.;* Li, J.; Shi, B.; Li, M.; Zhang, G.;* Zhang, X., Rh(III)-Catalyzed Oxidative Domino C-H/N-H Annulation: Diarylureas as Arylamine Donors for the Assembly of Indolo[2,1-a]isoquinolines. J. Org. Chem. 2022, 87, 13672-13682. https://doi.org/10.1021/acs.joc.2c01334


59. Zhang, Z.;* Cao, X.; Song, X.; Wang, G.; Shi, B.; Li, X.; Ma, N.; Liu, L.; Zhang, G.,* Metal-free nucleophilic 7,8-dearomatization of quinolines: Spiroannulation of aminoquinoline protected amino acids. Chin. Chem. Lett. 2023, 34, 107779. https://doi.org/10.1016/j.cclet.2022.107779

60. Zhang, G.;* Chen, L.; Hu, Z.; Zhang, Z.;* Bi, J.; Li, M.; Zhang, X., Organocatalytic Cloke–Wilson Rearrangement: Carbocation-Initiated Tandem Ring Opening/Cyclization of Cyclopropanes under Neutral Conditions. J. Org. Chem. 2023, 88, 1003-1017. https://doi.org/10.1021/acs.joc.2c02415

61.  Shi, B.; Zhang, Z.; Cao, X.; Ma, N.; Li, S.; Wu, H.; Zhang, X.; Zhang, G., Anion Cascade Reactions II: Synthesis of 3-Isoquinuclidone-Based Bridged Polycyclic Lactams. Org. Lett. 202325, 6846-6852. https://doi.org/10.1021/acs.orglett.3c02356


62.  Li, M.; Zhang, Z.;* Ma, N.; Zhao, J.; Wu, H.; Liu, Q.; Zhang, G.* Anion Cascade Reactions. Part I: Synthesis of 3-Isoquinuclidones from a Nazarov-like Reagent. Org. Lett. 202325, 6840-6845. https://doi.org/10.1021/acs.orglett.3c02355


63.  Li, M.; Li, J.; Zhang, Z.;* Chen, L.; Ma, N.; Liu, Q.; Zhang, X.; Zhang, G.* Palladium-catalyzed intramolecular aza-Wacker-type cyclization of vinyl cyclopropanecarboxamides to access conformationally restricted aza[3.1.0]bicycles. RSC Advances 2023, 13, 27158-27166. https://doi.org/10.3390/molecules28093691

    


64.  Li, J.; Zhang, Z.;* Chen, L.; Li, M.; Zhang, X.; Zhang, G.* Base-Promoted Intramolecular Addition of Vinyl Cyclopropanecarboxamides to Access Conformationally Restricted Aza[3.1.0]bicycles. Molecules 2023, 28, 3691. https://doi.org/10.1039/d3ra05440c


专利情况:

1. 张志国,刘青锋,张贵生,田庆,高选择性地脱除2,6-二甲基-4-吡啶酮衍生物的α-单甲基的简单、有效的方法,ZL201210469746.8,授权日期:2014.08.27。

2. 张志国,刘青锋,张贵生,田庆,2,6-二甲基-4-吡啶酮衍生物的2位和6位甲基的简单、有效的脱去方法,ZL201210517552.0,授权日期:2014.08.27。

3. 张志国,郑丹,麻娜娜,张贵生,刘青锋,一种合成呋喃[2,3-b]喹啉类化合物的方法,ZL201510195570.5,授权日期:2020.04.28。

4. 张志国,黄媛媛,麻娜娜,张贵生,刘青锋,一种合成4氢-吡咯[3,2-c]吡啶-4-酮类化合物的方法,ZL201510195454.3,授权日期:2020.04.28。

5. 张志国,曹夕阳,张贵生,一种联烯类化合物双磺酰化的方法,ZL202110537926.4,授权日期:2022.04.26。

6. 张志国,胡兆康,张贵生,刘青锋,一种合成2,4-双取代喹啉类化合物的新方法,ZL02110613110.5,授权日期:2022.06.03。

7. 张贵生,刘青锋,张志国,具有抗癌活性的3'-叠氮基表阿霉素的合成,ZL201110023054.6,授权日期:2014.06.25。

8.  张志国,高文婧,张贵生,麻娜娜,一种合成6-吡啶[1,2-c]喹唑啉-6-酮类化合物的新方法,ZL201811630556.3,授权日期:2022.09.13。

9. 张志国,曹夕阳,张贵生,一种不对称丙二酰胺类化合物及其合成方法,ZL202111615221.6,授权日期:2023.09.22。

10. 张志国,胡兆康,张贵生,刘青锋,一种合成2,3-二氢呋喃类化合物的方法,申请号:202111613650X,授权日期:2023.01.17

11. 张志国,高文婧,张贵生,麻娜娜,一种合成吡啶[1’,2’:1,5]吡唑[3,4-b]喹喔啉类化合物的方法,申请号:201811629925.7,授权日期:2024.04.16。

12. 张贵生,张志国,麻娜娜,刘青锋,李忠联,一种氧化1,3-二羰基化合物的亚甲基成酮的方法,申请号:201510214235.5,申请日期:2015.04.10。

13. 张贵生,张志国,麻娜娜,刘青锋,张伟,一种将2,3-二氢吡咯氧化成吡咯的方法,申请号:201510195453.9,申请日期:2015.04.10。

14. 张志国,张贵生,闫严,刘青锋,一种二级酰胺类化合物的合成方法,申请号:201611135725.7,申请日期:2016.12.18。

15. 张志国,李祥,张贵生,麻娜娜, 一种去除氨基上喹啉保护基的新方法,申请号:201811514058.2,申请日期:2018.11.29。



获奖和荣誉:


1. 东北师范大学,研究生学术活动先进个人,2008年。

2. 东北师范大学,优秀研究生奖学金,2008年。

3. 东北师范大学,优秀研究生奖学金,2010年。

4. 东北师范大学,研究生优秀毕业生,2010年。

5. 河南师范大学,优秀教师,2011年。

6. 吉林省优秀博士学位论文,吉林省学位委员会,2012年5月。

7. 河南省优秀博士后研究人员,河南省人力资源和社会保障厅,2014。

8. 河南师范大学“优秀青年科研创新人才”,2014年12月。

9. 河南省高校青年骨干教师,河南省教育厅,2014年。

10. 河南师范大学青年五四奖章,2016年5月。

11. 河南省高校科技创新人才支持计划,河南省教育厅,2017年。

12. 河南省杰出青年科学基金,2022年。

13. 河南省教育厅学术技术带头人,2022年。



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