张丹丹，博士

E-mail: ddz1110@126.com

教育经历：

2010.09-2014.07，河南师范大学，学士，化学

2014.09-2017.07，河南师范大学，硕士，制药工程，导师：李伟教授，姜玉钦教授

2017.09-2022.07，河南师范大学，博士，化学，导师：丁清杰教授，姜玉钦教授

讲授课程：

药物分析、药物分析实验、化学制药工艺学

研究领域：

抗肿瘤新药的研究与开发、药物合成工艺研究

代表性论文：

[1] Dandan Zhang#*, Jie Zhao#, Guiqing Xu#, Yue Wang, Yang Li, Hanxiao Ren, Jiajun Geng, Yu Du, Chenchen Zhang, Shouning Yang, Dongfang Liu, Jiajing Gao, Yi Xiong, Haoyi Zhang, Wei Li, Wei Wang, Di Wang, Biao Li, Xing He,* Chunhua Ma,* Yuqin Jiang,* Qingjie Ding.* Discovery of imidazo[1,2 b]pyridazine derivatives as potent and highly selective irreversible Bruton’s Tyrosine Kinase (BTK) inhibitors, Journal of Medicinal Chemistry, 2025, 68: 10897-10929.

[2] Dandan Zhang#, Guiqing Xu#, Jie Zhao#, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang, Chunhua Ma*, Yuqin Jiang*, Qingjie Ding*. Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase. Eur. J. Med. Chem., 2021, 225, 113724-113746.

[3] Chunhua Ma*, Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu*, Yuqin Jiang*, Qingjie Ding*. Discovery of 1 Amino 1H imidazole-5-carboxamide Derivatives as Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitors. J. Med. Chem., 2021, 64, 16242-16270.

代表性专利：

[1] Yuqin Jiang, Dandan Zhang, Qingjie Ding, Chunhua Ma, Guiqing Xu, Wei Li, Shouning Yang, Yang Li, Chenchen Zhang, Lu Zhao, Zongjing Hao, Xin Shi, Peipei Shi. Substituted 1H-imidazo[1,2-b]pyrazole-3-carboxamide as Bruton’s tyrosine kinase inhibitors. WO 2022/012550 A1, 2022-01-20.

[2] Yuqin Jiang, Qingjie Ding, Chunhua Ma, Guiqing Xu, Dandan Zhang, Yang Li, Pengfei Li, Wei Li, Shouning Yang, Xin Shi, Peipei Shi. Substituted imidazolecarboxamide as Bruton's Tyrosine Kinase inhibitors. WO 2021/110142 A1, 2021-06-10.

[3] 姜玉钦, 张丹丹, 杨婷婷, 李锡勇, 孙亚敏, 徐桂清, 李伟. 一种以羧甲基纤维素钠为催化剂采用高压釜制备曲克芦丁的方法. ZL201710120146.3, 2020-01-31.

科研奖励：

 1、曲克芦丁关键技术创新及产业化应用，河南省科技进步二等奖，第二完成人，2023年。

2、曲克芦丁合成关键技术创新及产业化，河南省教育厅科技成果奖一等奖，第九完成人，2020年。