讲师

杨钧棠

发布时间:2019-11-15






姓   名:   杨钧棠

职   称:   讲师

办公电话:   

电子邮箱:  2018207@htu.edu.cn










个人简介:

   博士毕业于第三军医大学,博士期间主要从事肺癌和乳腺癌发病机制研究工作,发现了Wnt/β-catenin通路在肺癌中的新的调控机制,该通路在胚胎发育,肿瘤发生以及肺纤维化中发挥关键功能。博士毕业后于美国希望城国家医学中心从事DNA损伤修复与肺癌发生关系的研究。2018年7月进入河南师范大学生命科学学院工作,从事肺纤维化发病机理的研究。目前总计发表SCI论文10篇,其中5分以上5篇,第一作者4篇(>5分1篇),共同第一作者1篇(>5分)。

研究领域:

    肺纤维化发病机制研究。

主要学术及社会兼职:

    无

主持或参加科研项目情况:

1. 河南省高等学校重点科研项目(20A310006)       2019-2021    主持

2. 河南师范大学博士科研启动基金(5101049170182) 2019-2022    主持

3. 河南省自然科学基金 (202300410227)             2021-2022    主持

学术成果:

1. Juntang Yang, Xin Pan,Lan Wang, Guoying Yu.Alveolar cells under mechanical stressed niche:critical contributors to pulmonary fibrosis. Molecular Medicine(IF=4.09) (2020) 26:95

2. Yang JT, Wang Lan, Pan Xin, Zhao Weiming, Zhang Xinsheng, Yu Guoying. Mechanical Stress Contribute to Pulmonary Fibrosis viaMitochondria! Damage of Type II Alveolar Epithelial Cells. American journal of respiratory and critical care medicine. (IF=17.452) (2020)201

3. Fei Han, Li Yin, Xiao Jiang, Xi Zhang, Ning Zhang, Jun-tang Yang,Wei-ming Ouyang, Xiang-lin Hao, Wen-bin Liu, Yong-sheng Huang, Hong-qiang Chen, Fei Gao,Zhong-tai Li, Qiao-nan Guo, Jia Cao, Jin-yi Liu, Identification of SRY-box 30as an age-related essential gatekeeper for male germ-cell meiosis and differentiation. Aging Cell (IF=7.238) 2021;00:e13343

4. Tang CZ#, Yang JT#(共同第一), Liu QH, Wang YR, Wang WS: Up-regulated miR-192-5p expression rescues cognitive impairment and restores neural function in mice with depression via the Fbln2-mediated TGF-beta1 signaling pathway. FASEB journal(IF=5.595) : official publication of the Federation of American Societies for Experimental Biology 2019, 33(1):606-618.

5. Tang CZ, Zhang DF, Yang JT,Liu QH, Wang YR, Wang WS. Overexpression of microRNA-301b accelerate shippocampal microglia activation and cognitive impairment in mice with depressive-like behavior through the NF-κB signaling pathway. Cell Death Dis (IF=5.638). 2019 Apr 8;10(4):316. doi: 10.1038/s41419-019-1522-4.

6.Han F, Liu WB, Li JJ, Zhang MQ, Yang JT, Zhang X, Hao XL, YinL, Mao CY, Jiang X et al: SOX30 is a prognostic biomarker and chemotherapeutic indicator for advanced-stage ovarian cancer. Endocrine-related cancer(IF=5.331) 2019.

7. Han F, Liu WB, Shi XY, Yang JT, Zhang X, Li ZM,Jiang X, Yin L, Li JJ, Huang CS et al: SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of beta-Catenin in Lung Cancer. EBioMedicine (IF=6.138) 2018, 31:253-266.

8. Yang J, Han F, Liu W, Chen H, Hao X, Jiang X, Yin L,Huang Y, Cao J, Zhang H et al: ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/beta-catenin pathway. Journal of experimental & clinical cancer research : CR(IF=6.217) 2017, 36(1):170.

9. Yang J, Han F, Liu W, Zhang M, Huang Y, Hao X, Jiang X, Yin L, Chen H, Cao J et al: LHX6, An Independent Prognostic Factor, Inhibits Lung Adenocarcinoma Progression through Transcriptional Silencing ofbeta-catenin. Journal of Cancer 2017(IF=3.2),8(13):2561-2574.

10. Yang J, Wang R,Liu B, Xue Q, Zhong M, Zeng H, Zhang H: Kinetic analysis of bypass of abasicsite by the catalytic core of yeast DNA polymerase eta. MutationResearch/Fundamental and Molecular Mechanisms of Mutagenesis (IF=2.5) 2015, 779:134-143.