蒋涛，男，博士，讲师，学科建设秘书
Email：jiangtao@htu.edu.cn
教育经历：
2008.9-2013.6 武汉大学化学与分子科学学院，获理学博士学位
2004.9-2008.6河南师范大学化学与环境科学学院，获理学学士学位
工作经历：
2025.12-至今河南师范大学，药学院/抗病毒性传染病创新药物全国重点实验室
2014.04-至今河南师范大学，化学化工学院
研究领域与兴趣：
生物医用材料、肿瘤免疫治疗、纳米药物释系统
近年来主持的主要科研项目：
1.河南省科技攻关计划项目：糖基化脂质体负载2',3'-cGAMP纳米药物用于精准靶向肝癌的免疫治疗，2025.01-2026.12
2.河南省自然科学基金青年科学基金：树状聚赖氨酸负载阿霉素/2',3'-cGAMP协同增强肿瘤免疫治疗效果研究，2021.01-2022.12
3.河南省科技攻关计划项目：树状聚赖氨酸负载阿霉素/cGAMP协同增强肿瘤的免疫治疗，2021.01-2022.12
4.河南省高等学校重点科研项目：生物可降解聚碳酸酯前药载体的设计、合成及性能研究，2015.01-2016.12
5.新乡市科技攻关项目：生物可降解聚碳酸酯在改善紫杉醇类药物水溶性中的应用，2014.01-2016.12
6.河南师范大学国家级科研项目培育基金：聚碳酸酯前药的设计、合成及靶向性能研究，2017.1-2019.12
7.河南师范大学青年科学基金项目：基于生物可降解聚碳酸酯前药载体的合成及靶向性能研究，2015.1-2017.12
8.横向项目：医用聚乳酸增韧剂开发，2023.12-2025.11
9.横向项目：纺织物微生物检测合作，2022.03-2026.02
代表性论文：
Di Xie, Jiwei Tang, Tingting Zhang, Wenpei Dong, Tao Jiang, Jinliang Ma*, Chang-Po Chen*. A Bimolecular Simultaneous Macrocyclization Strategy to Synthesize Cyclic Dinucleotide Analogues with Internucleoside Guanidinium Linkages, Journal of Organic Chemistry, 2025, 90(37), 13145–13155.
Peng Zhou, Gen Yang, Yan Wang, Yaya Peng, Lingyun Xu, Tao Jiang, Jinliang Ma*, Wenpei Dong*, Chang-Po Chen*. Development of indole derivatives as inhibitors targeting STING-dependent inflammation, Bioorganic & Medicinal Chemistry, 2025, 126, 118216.
Wenpei Dong, Lingyun Xu, Mengting Chen, Tao Jiang, Li Su*, Jinliang Ma, Chang-po Chen*, Guisheng Zhang*. Co-, N-doped carbon dot nanozymes based on an untriggered ROS generation approach for anti-biofilm activities and in vivo anti-bacterial treatment, Journal of Materials Chemistry B, 2024, 12, 1052-1063.
Jinliang Ma*, Hui Xu, Ke Hou, Yaru Cao, Di Xie, Jiayin Yan, Wenpei Dong, Tao Jiang, Chang-Po Chen*. Design and Synthesis of Cyclic Dinucleotide Analogues Containing Triazolyl C-Nucleosides, Journal of Organic Chemistry, 2024, 89(16): 11380–11393.
Wenpei Dong, Mengting Chen, Chun Chang, Tao Jiang, Li Su, Changpo Chen*, Guisheng Zhang*. Remodeling of Tumor Microenvironment by Nanozyme Combined cGAS–STING Signaling Pathway Agonist for Enhancing Cancer Immunotherapy, International Journal of Molecular Sciences, 2023, 24, 13935.
Wenpei Dong, Lingyun Xu, Chun Chang, Tao Jiang*, Chang-po Chen*, Guisheng Zhang*. A novel self-assembled nucleobase-nanofiber platform of CDN to activate the STING pathway for synergistic cancer immunotherapy, Colloids and Surfaces B-Biointerfaces, 2023, 232, 113597.
陈长坡*, 闫佳音, 牛美, 曹冠洋, 李飒, 毕晶晶, 董文佩, 蒋涛, 辛鹏洋. 环二核苷酸类似物研究进展. 河南师范大学学报.自然科学版. 2021, 49（05）:59-74.
Pengyang Xin*, Lingyu Zhao, Linlin Mao, Linqi Xu, Shuaimin Hou, Huiyuan Kong, Haodong Fang, Haofeng Zhu, Tao Jiang, Chang-Po Chen*. Effect of charge status on the ion transport and antimicrobial activity of synthetic channels, Chemical Communications, 2020, 56, 13796-13799.
Yanwei Chi, Zhiying Wang, Jie Wang, Wenpei Dong, Pengyang Xin, Jingjing Bi, Tao Jiang*, Chang-Po Chen*, Dimeric Camptothecin-loaded mPEG-PCL nanoparticles with high drug loading and reduction-responsive drug release. Coloid and Polyer Science,2020, 298, 51–58.
Tao Jiang, Xin Wang, Ge Wang, Yafu Wang, Kui Wang, Xiaopeng Xuan, Changpo Chen*, Kai Jiang, Hua Zhang*. Light-activated cycle-reversible intramolecular charge transfer fluorescent probe: monitoring of pHi trace change induced by UV light in programmed cell death, Chem. Commun.2019, 55,5279-5282.
Pengyang Xin*, Huiyuan Kong, Yonghui Sun, Lingyu Zhao, Haodong Fang, Haofeng Zhu, Tao Jiang, Jingjing Guo, Qian Zhang, Wenpei Dong, Chang-Po Chen* Artificial K+ Channels Formed by Pillararene-Cyclodextrin Hybrid Molecules:, Tuning Cation Selectivity and Generating Membrane Potential. Angewandte Chemie International Edition. 2019, 58(9): 2779-2784.
Pengyang Xin, * Yonghui Sun, Huiyuan Kong, Yaodong Wang, Si Tan, Jingjing Guo, Tao Jiang, Wenpei Dong,* Chang-Po Chen*. A unimolecular channel fromed by dual helical peptide modified pillar[5]arene: correlating transmembrane transport properties with antimicrobial activity and haemolytic toxicity Chem. Comm. 2017, 53, 11492-11495
Pengyang Xin,* Si Tan, Yonghui Sun, Qiaojv Ren, Wenpei Dong, Jingjing Guo, Tao Jiang and Chang-Po Chen*One-pot formation of hydrazide macrocycles with modified cavities: an example of pH-sensitive unimolecular cation channels Chem. Comm. 2017, 52, 5322-5325.
Hua Zhang*, Caixia Wang, Tao Jiang, Haiming Guo*, Ge Wang, Xinhua Cai, Lin Yang, Yi Zhang, Haichuan Yu, Hui Wang, and Kai Jiang . Microtubule-Targetable Fluorescent Probe: Site-Specific Detection and Super-Resolution Imaging of Ultratrace Tubulin in Microtubules of Living Cancer Cells. Analytical Chemistry.2015, 87, 5216-5222.
Hua Zhang*,Jiangli Fan, Kui Wang, Jing Li, Caixia Wang, Yamin Nie, Tao Jiang, Huiying Mu, Xiaojun Peng, and Kai Jiang. Highly Sensitive Naphthalene-Based Two-Photon Fluorescent Probe for in Situ Real-Time Bioimaging of Ultratrace Cyclooxygenase‑2 in Living Biosystems. Analytical Chemistry.2014, 86, 9131-9138.
Tao Jiang, Feng He, Renxi Zhuo. Synthesis, characterization and enzymatic degradation of novel biodegradable copolymers of5-allyloxy-1,3-dioxan-2-one with ε-caprolactone. Polymer Degradation and Stability. 2013, 98(1), 325-330.
Tao Jiang, Youmei Li, Yin Lv, Yinjia Cheng, Feng He and Renxi Zhuo. Amphiphilic polycarbonate conjugates of doxorubicin with pH-sensitive hydrazone linker for controlled release. Colloids and Surfaces B: Biointerfaces. 2013, 111, 542-548.
Tao Jiang, Youmei Li, Yin Lv, Yinjia Cheng, Feng He, Renxi Zhuo Amphiphilic Block-Graft copolymers based on Poly(ethylene glycol)-b-(polycarbonates-g-polycarbonates) for Controlled Release of Doxorubicin. Journal of Materials Science-Materials in Medicine 2014, 25, 131-139.
郑晓明，蒋涛，贺枫. PNIPAM-b-聚碳酸酯温敏胶束的制备及用作药物控制释放载体的研究. 高分子学报，2011,8, 895-902
Feng He*, Changfang Wang, Tao Jiang, Bing Han, Renxi Zhuo. Poly[(5-methyl-5-allyloxycarbonyl-trimethylenecarbonate)-co-(5,5-dimethyl-trimethylenecarbonate)] with Grafted Polyethylenimine as Biodegradable Polycations for Efficient Gene Delivery. Biomacromolecules. 2010, 11, 3028-3035.
Changfang Wang, Yanxin Lin, Tao Jiang, Feng He*, Renxi Zhuo. Polyethylenimine-grafted polycarbonates as biodegradable polycations for gene delivery. Biomaterials. 2009, 30, 4824-4832.