王梦琪 博士，讲师，硕士生导师

联系方式：2025126@htu.edu.cn

教育经历：

2021.09-2025.07 河南师范大学   理学博士

2018.09-2021.07 河南大学       医学硕士

2014.09-2018.07 郑州华信学院   理学学士

工作经历：

2025年7月-至今，抗病毒性传染病创新药物全国重点实验室  讲师

研究领域与兴趣：

抗肿瘤、抗病毒药物设计合成与机制研究

近年来主持的主要科研项目：

1.国家自然科学基金青年基金，2027/01-2029/12，30万，在研，主持；

2.河南省科技攻关项目，2026/01-2027/12，10万，在研，主持；

3.河南师范大学博士科研启动基金，2026/01-2028/12，20万，在研，主持

代表性论文：

[1]     Wang, M.; Li, X.; Bai, Y.; Luo, W.; Gao, Y.; Xie, W.*; Su, C.*; Chang, J.*; Zhu, B.* Targeting PFKLwith S-Benzylisothiourea ImidazoliumSalt Derivatives to Suppress Glycolysis and Treat Breast Cancer. J. Med. Chem2026, 69 (15), 19018–19049. https://doi.org/10.1021/acs.jmedchem.6c01360.

[2]     Wang, M.; Yang, S.; Li, X.; Zheng, Y.; Bai, Y.; Luo, W.; Zhu, G.*; Chang, J.*; Zhu, B.* Discovery of Novel Aromatic Urea-Imidazole Salt Derivatives for Cancer Therapy via Targeting ERK1/2. J. Med. Chem.2025, 68 (4): 4101-4132..https://doi.org/10.1021/acs.jmedchem.4c01434.

[3]     Wang, M.; Li, L.; Yang, S.; Guo, F.; Zhu, G.*; Zhu, B.*; Chang, J. * Synthesis of Novel Oxazol-5-One Derivatives Containing Chiral Trifluoromethyl and Isoxazole Moieties as Potent Antitumor Agents and the Mechanism Investigation. Bioorganic Chemistry2023, 135, 106505. https://doi.org/10.1016/j.bioorg.2023.106505.

[4]     Wang, B.; Chang, X.; Wang, M.; Wang, L.; Zhao, X.; Zhao, C.; Lv, N.; Wang, L.; Su, C.*; Chang, J.*; Zhu, B.* Design of Dual-Targeting GABAARs and 5-HT2AR Molecules to Combat Neuroinflammation in Depressive Disorders. Bioorganic Chemistry2026, 176, 109878. https://doi.org/10.1016/j.bioorg.2026.109878

[5]     Sun, Y.*; Shu, Y.; Song, Y.; Wang, M.; Zheng, L.; Zhang, Q.; Su, C.; Chen, H.*; Chang, J.; Xin, P.* Pure Organic Near-Infrared Circularly Polarized Room-Temperature Phosphorescent Films Based on Cyclodextrins Chiral Pseudopolyrotaxane. Materials Today Chemistry2026, 51, 103324. https://doi.org/10.1016/j.mtchem.2025.103324.

[6]     Shan, M.; Yu, Y.; Yang, S.; Wang, M.; Shi, Q.*; Lan, Y.; Chang, J.*; Zhu, B.* Rational Design of Bifunctional Imidazoles as Acyl Transfer Catalysts: Dynamic Kinetic Resolution of 5-Hydroxy-Furanones/3-Hydroxy-Phthalides. J. Org. Chem. 2025. https://doi.org/10.1021/acs.joc.4c02808.

[7]     Shan, M.; Yu, Y.; Sun, M.; Yang, S.; Wang, M.; Zhu, B.*; Chang, J.* Bifunctional Organocatalyst-Catalyzed Dynamic Kinetic Resolution of Hemiketals for Synthesis of Chiral Ketals via Hydrogen Bonding Control. Chinese Chemical Letters2025, 36 (1), 109781. https://doi.org/10.1016/j.cclet.2024.109781.

[8]     Wang, L.; Zhu, X.; Wang, B.; Wang, Y.; Wang, M.; Yang, S.; Su, C.; Chang, J.*; Zhu, B.* Design, Synthesis, and Activity Evaluation of Fluorine-Containing Scopolamine Analogues as Potential Antidepressants. J. Med. Chem. 2024, 67 (7), 5391–5420. https://doi.org/10.1021/acs.jmedchem.3c01970.

[9]     Zhu, B.*; Sun, H.; Fan, H.; Wang, M.; Guo, F.; Zhai, Y.; Zhu, G.; Chang, J.* Asymmetric Brønsted Base-Catalyzed Aza-Michael Addition and [3 + 2] Cycloaddition Reactions of N-Ester Acylhydrazones and Enones. Org. Chem. Front.2022, 9 (23), 6631–6639. https://doi.org/10.1039/D2QO01527G.

[10]  Zhu, B.*; Fan, H.; Ding, Y.; Zhai, Y.; Wang, L.; Wang, M.; Zhu, G.; Chang, J.* Copper(I)-Catalyzed Asymmetric [3 + 2] Cycloaddition of N-Ester Acylhydrazones and β-Trifluoromethyl-α,β-Unsaturated Ketones. Org. Chem. Front.2022, 9 (20), 5544–5550. https://doi.org/10.1039/D2QO00993E.