王梦琪 博士，讲师

联系方式：2025126@htu.edu.cn

教育经历：

2021.09-2025.07 河南师范大学   理学博士

2018.09-2021.07 河南大学       医学硕士

2014.09-2018.07 郑州华信学院   理学学士

工作经历：

2025年7月-至今，抗病毒性传染病创新药物全国重点实验室  讲师

研究领域与兴趣：

抗肿瘤、抗病毒药物设计合成与机制研究

代表性论文：

[1]     Wang, M.; Yang, S.; Li, X.; Zheng, Y.; Bai, Y.; Luo, W.; Zhu, G.; Chang, J.; Zhu, B. Discovery of Novel Aromatic Urea-Imidazole Salt Derivatives for Cancer Therapy via Targeting ERK1/2. J. Med. Chem.2025, 68 (4): 4101-4132..https://doi.org/10.1021/acs.jmedchem.4c01434.

[2]     Wang, M.; Li, L.; Yang, S.; Guo, F.; Zhu, G.; Zhu, B.; Chang, J. Synthesis of Novel Oxazol-5-One Derivatives Containing Chiral Trifluoromethyl and Isoxazole Moieties as Potent Antitumor Agents and the Mechanism Investigation. Bioorganic Chemistry2023, 135, 106505. https://doi.org/10.1016/j.bioorg.2023.106505.

[3]     Shan, M.; Yu, Y.; Yang, S.; Wang, M.; Shi, Q.; Lan, Y.; Chang, J.; Zhu, B. Rational Design of Bifunctional Imidazoles as Acyl Transfer Catalysts: Dynamic Kinetic Resolution of 5-Hydroxy-Furanones/3-Hydroxy-Phthalides. J. Org. Chem. 2025. https://doi.org/10.1021/acs.joc.4c02808..

[4]     Shan, M.; Yu, Y.; Sun, M.; Yang, S.; Wang, M.; Zhu, B.; Chang, J. Bifunctional Organocatalyst-Catalyzed Dynamic Kinetic Resolution of Hemiketals for Synthesis of Chiral Ketals via Hydrogen Bonding Control. Chinese Chemical Letters2025, 36 (1), 109781. https://doi.org/10.1016/j.cclet.2024.109781.

[5]     Wang, L.; Zhu, X.; Wang, B.; Wang, Y.; Wang, M.; Yang, S.; Su, C.; Chang, J.; Zhu, B. Design, Synthesis, and Activity Evaluation of Fluorine-Containing Scopolamine Analogues as Potential Antidepressants. J. Med. Chem. 2024, 67 (7), 5391–5420. https://doi.org/10.1021/acs.jmedchem.3c01970.

[6]     Zhu, B.; Sun, H.; Fan, H.; Wang, M.; Guo, F.; Zhai, Y.; Zhu, G.; Chang, J. Asymmetric Brønsted Base-Catalyzed Aza-Michael Addition and [3 + 2] Cycloaddition Reactions of N-Ester Acylhydrazones and Enones. Org. Chem. Front.2022, 9 (23), 6631–6639. https://doi.org/10.1039/D2QO01527G.

[7]     Zhu, B.; Fan, H.; Ding, Y.; Zhai, Y.; Wang, L.; Wang, M.; Zhu, G.; Chang, J. Copper(I)-Catalyzed Asymmetric [3 + 2] Cycloaddition of N-Ester Acylhydrazones and β-Trifluoromethyl-α,β-Unsaturated Ketones. Org. Chem. Front.2022, 9 (20), 5544–5550. https://doi.org/10.1039/D2QO00993E.