杨守宁，男，博士，副教授，博士生导师。
E-mail: yangshouning@htu.edu.cn
教育经历：
2011-2015 华东师范大学 有机化学 博士
2004-2007 华东师范大学 有机化学 硕士
2000-2004 河南师范大学 化学教育 学士
工作经历：
2016-至今 河南师范大学 化学化工学院 副教授
2007-2015 上海清松制药有限公司 新药部 项目经理
研究领域与兴趣：
抗菌、抗癌小分子药物的设计合成，纳米药物的设计合成，蛋白质变性相关疾病检测。擅长小分子药物设计、合成工艺开发。
近年来主持的主要科研项目：
国家自然科学基金-面上项目 | 一种双酰肼基肽脱甲酰基酶抑制剂的设计合成及活性研究 | 主持（1/10） | |
国家自然科学基金-河南联合基金 | 基于恶性肿瘤光热/光动力/免疫协同治疗的铋基纳米复合材料的构筑、构效关系与机制研究 | 参与（2/10） | |
河南省高等学校重点科研项目 | 金属蛋白酶抑制剂关键中间体的合成方法研究 | 主持（1/5） |
代表性论文：
1. Shouning Yang, Ran Guo, Shuai Zhang, Fangxiao Li, Jinliang Liu *, Huayan Yang. Bi₂Se₃@BiSe heterostructures for triple-modal anticancer therapy: Integrating photothermal, photodynamic, and immunotherapeutic approaches, Journal of Colloid and Interface Science,2026, 710, 140047.
2. Shouning Yang, Zhiqin Zhang, Shengkun Wang, Jian Song, Yide Liu, Ying Zhang, Shenghai Guo, Yuqin Jiang, Chunlei Wang*, Huayan Yanga*. A general design strategy for smart covalent fluorescent probes enabling protein aggregation detection through chromogenic switching，Sensors & Actuators: B. Chemical, 2026, 446 138692.
3. Shouning Yang, Yaru Wang, Yujie Yang, Zhiqin Zhang, Fengfeng Li, Lingling Tao, Ling Han, Shenghai Guo, Ying Zhang, Yuqin Jiang, Junbiao Chang*, Huayan Yang*. Design, Synthesis, and Biological Evaluation of 1,3,4-Thiadiazole Derivatives as Novel Potent Peptide Deformylase Inhibitors for Combating Drug-Resistant Gram-Positive and -Negative Bacteria, Journal of Medicinal Chemistry 2025, 68, 2942−2962.
4.Shouning Yang, Ying zhang, shuai zhang, Shenghai Guo, Yuqin Jiang,Huayan Yang*. Photo-Augmented DHFR Inhibition: N-Methylbenzothiazole Derivatives against Resistant Gram ± Bacteria.ACS Infectious Diseases2025, 11, 3567−3580.
5.Shouning Yang, Hongyan Jia, Shuai Zhang, Shengkun Wang, Shenghai Guo, Huayan Yang*. Novel D-π-A fluorescence sensor array with dual-sensitivity for machine learning-driven pathogen discrimination: from species to drug resistance. Microchemical Journal2025, 218, 115609.
6. Shouning Yang, Hongyan Jia, Yide Liu, Shengkun Wang, Lingling Tao, Shenghai Guo, Chunlei Wang*,Huayan Yang*. Species- and subspecies-level differentiation of cancer cells based on viscosity sensitive fluorescence sensor array and machine learning, Microchemical Journal 2025, 213, 113682.
7. Yinwei Qiu, Fangxiao Li, Shuai Zhang, Chunlei Wang, Shouning Yang*, Junjie Chen*, Huayan Yang*. Cation-π Interactions Mediated Copper-Based Nanoplatform for Synergistic Chemodynamic-Chemotherapy with Enhanced Anticancer Efficacy,Langmuir, 2025, 27, 7076.
8. Shouning Yang, Xiaoyang Liu, Shengkun Wang, Jian Song, Jichun Wu, Baoxing Shen, Hongyan Jia, Shenghai Guo, Yaru Wang, Yujie Yang, Yuqin Jiang, Junbiao Chang*, Huayan Yang*. Chalcone Derivatives as Dual-sensitive Fluorescent Probe for Protein Aggregation Investigation., Sensors and Actuators B: Chemical, 2023, 395 (15), 134514
9. Shouning Yang, Shengkun Wang, Yanmin Zhang, Yijing Wang, Jinhong Yuan, Yuqin Jiang, Xing He, Lihong Liu, Jian Song, Liang Chen*, Huayan Yang*. Heterojunction structured BiOCl-Bi2S3 nanosheets as mitochondria-targeted near-infrared photothermal and photodynamic therapy agent. Colloids and Surfaces B: Biointerfaces. 2023, 222, 113106.
10. Shouning Yang, Shengkun Wang, Yaru Wanga, Jian Song, Yuqin Jiang, Liang Chen*, Huayan Yang*. Ultrathin Two-Dimensional BiOCl-Bi2S3-Cu2S Ternary Heterostructures with Enhanced LSPR effect for NIR Photonic Bacterial Disinfection.Chemistry - A European Journal. 2023, e202203831.
11. Huayan Yang, Sijia Lu, Shengkun Wang, Lihong Liu,Bo Zhu, Shaoning Yu, Shouning Yang* andJunbiao Chang*. Evolution of the protein corona affects macrophage polarization. International Journal of Biological Macromolecules. 2021, 191,192-200.
12. Huayan Yang, Yanmin Zhang, Jian Song, Meng Wang, Shaoning Yu, Liang Chen, Xiaomin Li, Shouning Yang*, Lin Yang*. Boosting Phototherapeutic Efficiency with Single NIR Laser-Activated Ultrasmall Bismuth Sulfide Quantum Dots. Chemical Engineering Journal. 2019, 375, 121941.
13.Huayan Yang, Meng Wang, Yanmin Zhang, Xiaoyang Liu, Yuming Guo, Shaoning Yu, Shouning Yang*,Lin Yang*. Detailed insight into the formation of protein corona: conformational change, stability and aggregation. International Journal of Biological Macromolecules, 2019, 135(15), 1114-1122.
14. Shouning Yang, Xiaoyang Liu, Sijia Lu, Zhuo Li, Yanmin Zhang, Shaoning Yu, Jian Song, Chuanfan Ding, and Huayan Yang*. Novel Facile One-Pot Synthesis of Bi2S3-BiOCl Ultrathin Hetero-nanosheets for Selective Alcohol Oxidation. ChemCatChem, 2021, 13, 2293 -2302.
15. Shouning Yang，Yuyan Xue, Yanmin Zhang, Sijia Lu, Junli Wu, Lin Yang, Huayan Yang*, and Shaoning Yu*. Mitochondrial Targeting Strategy for Enhanced Photothermal Cancer Therapy. ChemNanoMat, 2021, 7, 1 – 11.
16. Shouning Yang, Yanmin Zhang, Sijia Lu, Lin Yang, Shaoning Yu, and Huayan Yang*. CaCO3‐Encapsulated Au Nanoparticles Modulate Macrophages toward M1-like Phenotype. ACS Appl. Bio Mater.2021, 4, 3214-3223.
17.Chunhua Ma, Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu,* Yuqin Jiang,* and Qingjie Ding*. Discovery of 1-amino-1h-imidazole-5-carboxamide derivatives as highly selective, covalent Bruton’s Tyrosine Kinase (BTK) inhibitors. Journal of Medicinal Chemistry, 2021, 64(21), 16242-16270.
18.Dandan Zhang, Guiqing Xu, Jie Zhao, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang, Chunhua Ma*, Yuqin Jiang*, Qingjie Ding*. Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase. European Journal of Medicinal Chemistry, 2021, 225, 113724(1-23). (SCI, IF：7.08)
19. Shouning Yang, Yanmin Zhang, Sijia Lu, Lihong Liu, Lin Yang, Yuming Guo, Shaoning Yu, Huayan Yang*. Labeled-protein corona-coated Bi2S3 nanorods targeted to lysosomes for bioimaging and efficient photothermal cancer therapy. Colloids and Surfaces B: Biointerfaces2020, 196, 111291.
20. Huayan Yang, Meng Wang, Yanmin Zhang, Feng Li, Shaoning Yu, Lin Zhu, Yuming Guo, Lin Yang and Shouning Yang*. Conformational-transited protein corona regulated cell-membrane penetration and induced cytotoxicity of ultrasmall Au nanoparticles. RSC Advances, 2019, 9, 4435-4444.
21. Shouning Yang, Wei Shi, Dong Xing, Zheng Zhao, Fengping Lv, Liping Yang, Yushe Yang, Wenhao Hu*. Synthesis, antibacterial activity, and biological evaluation of formyl hydroxyamino derivatives as novel potent peptide deformylase inhibitors against drug-resistant bacteria. European Journal of Medicinal Chemistry, 2014, 86: 133-152.