马春华，男，博士，副教授，制药工程系主任
河南省高校科技创新人才，河南省科技副总
联系方式：2016007@htu.edu.cn
教育经历：
2004.09-2008.06 山东大学药学院，药学专业，理学学士；
2008.09-2013.12 山东大学药学院，药物化学专业，理学博士；
工作经历：
2013.12-2015.12，复旦大学药学院，药物化学专业，博士后；
2016.03-2023.03，河南师范大学化学化工学院讲师;
2023.03-2025.12，河南师范大学化学化工学院副教授;
2025.12-至今，河南师范大学药学院副教授;
研究领域与兴趣：
1、基于靶标的新药创制
2、基于分子编辑的药物合成方法学研究
近年来主持的主要科研项目：
1、国家自然科学基金青年基金：基于腺嘌呤替代物的双底物SAHH抑制剂的设计、合成及活性研究，项目批准号：82003585, 2021.01-2023. 12, 24万元
2、河南省高校科技创新人才：基于腺嘌呤替代物的nsp14 N7-Mtase抑制剂的设计、合成及抗新冠活性研究，项目批准号：24HASTIT069，2024.01-2026.12，30万元
3、企业横向：基于新型腺嘌呤替代物的抗肿瘤药物研发，200万元
4、河南省自然科学基金面上项目（2025年）：靶向催化赖氨酸的共价ALK抑制剂的设计、合成及活性研究，10万元
5、河南省自然科学基金：小分子神经生长因子模拟物的设计、合成及作用机制研究，项目编号：162300410182, 2017.1-2018.12, 10万元
6、河南省高等学校重点科研项目基础研究计划：小分子NGF模拟物的设计、合成及应用研究，项目编号：17A350008, 2017.1-2018.12，3万元
7、高端外国专家项目：I类新药布鲁顿酪氨酸激酶抑制剂（BTK inhibitor HB040）的研究与开发，项目编号：GDW20186300346, 30万元
8、企业横向：新型BTK抑制剂的研究与开发，合同编号：XH2019059，50万元
获奖：
河南省优秀硕士学位论文指导教师
河南省优秀学士学位论文（毕业设计）指导教师
河南省“互联网+”大学生创新创业大赛优秀创新创业指导教师
Wiley China Excellent Author Program
代表性论文：
31) Chunhua Ma*, Qingyun Li, Minghao Zhao, Goujie Fan, Jie Zhao, Dandan Zhang, Shouning Yang, Shuting Zhang, Dingding Gao, Longfei Mao, Liang Zhu, Wei Li, Guiqing Xu,* Yuqin Jiang,* and Qingjie Ding*. Discovery of 1-amino-1H-imidazole-5-carboxamide derivatives as highly selective, covalent Bruton’s tyrosine kinase (BTK) inhibitors. Journal of Medicinal Chemistry, 2021, 64, 16242−16270.
30) Dandan Zhang1,*, Jie Zhao1, Guiqing Xu1, Yue Wang, Yang Li, Hanxiao Ren, Jiajun Geng, Yu Du, Chenchen Zhang, Shouning Yang, Dongfang Liu, Jiajing Gao, Yi Xiong, Haoyi Zhang, Wei Li, Wei Wang, Di Wang, Biao Li, Xing He*, Chunhua Ma*, Yuqin Jiang*, Qingjie Ding*. Discovery of imidazo[1,2-b]pyridazine derivatives as potent and highly selective irreversible bruton’s tyrosine kinase (BTK) inhibitors. Journal of Medicinal Chemistry, 2025, 68, 10897-10929.
29) Chunhua Ma, C. W. Lindsley*, Junbiao Chang*, Bin Yu*, Rational molecular editing: a new paradigm in drug discovery. Journal of Medicinal Chemistry, 2024, 67 (14), 11459-11466.
28) Baohu Li1, Hui Xu1, Xiaoyu Shi; Chunhua Ma*, Jinfei Yang*, Peng Zhan*, Clinical insight-driven novel drug development: Multidisciplinary integration and transformative opportunities. Acta Pharmaceutica Sinica B, 2026, 16, 651-655.
27) Dazhou Shi, Chunhua Ma*, Shujing Xu*, Peng Zhan*, Targeting the coronavirus membrane protein: A promising novel therapeutic strategy. Acta Pharmaceutica Sinica B, 2025, 15, 4309-4312.
26) Chunhua Ma, Junbiao Chang*, Bin Yu*, Sunlenca® (Lenacapavir): A first-in-class, long-acting HIV-1 capsid inhibitor for treating highly multidrug-resistant HIV-1 infection. Acta Pharmaceutica Sinica B,2024, 14, 5512-5514.
25) Chunhua Ma*, Linchun Shang, Na Jiang, Qingjie Ding, Zhong-Yan Cao, Yuqin Jiang*, Bing Yu*. Switchable divergent synthesis of cyclopropane scaffolds enabled by photoredox catalytic cascade. Organic Letters, 2025, 27, 8863–8868.
24) Chunhua Ma*, Qing Guo, Hui Meng, Shengnan Yan, Qingjie Ding, Yuqin Jiang*, Bin Yu *, Photoredox-catalyzed carbamoyl radical-initiated dearomative spirocyclization to access spiro-cyclohexadiene oxindoles. Organic Letters, 2024, 26, 8503-8508.
23）Chunhua Ma*, Mengjiao Liu, Siyu Ouyang, Zhenwei Cui, Jingjing Bi, Yuqin Jiang*, Zhiguo Zhang*, Metal-free construction of diverse 1,2,4-triazolo[1,5-a]pyridines on water. Chinese Chemical Letters, 2025, 36, 109755.
22）Yinghui Huang (本科生), Linhui Shen (本科生), Chunhua Ma*, Yuqin Jiang,* Bing Yu*, Functionalization of 1,3-butadiene derivatives under photo/electrocatalysis. European Journal of Organic Chemistry, 2024, 27, e202400403.
21）Jingyi Liu(本科生), Zhenwei Cui, Jingjing Bi, Xing He, Qingjie Ding*, Hong Zhu*, Chunhua Ma*, Photocatalytic fluoroalkylation by ligand-to-metal charge transfer. Frontiers in Chemistry, 2024, 12, 1481342.
20）Guiqing Xu, Jiayuan Lv, Qingjie Ding, Chunhua Ma,* Yuqin Jiang,* Bin Yu,* Direct C–H alkylation of benzothiadiazoles via organic photoredox catalysis. The Journal of Organic Chemistry, 2024, 89 (4), 2777-2781.
19) Chunhua Ma, Xiaofeng Li, Xiya Chen, Xing He, Shu-Ting Zhang,* Yu-Qin Jiang,* and Bing Yu*, Photocatalytic umpolung strategy for the synthesis of α-amino phosphine oxides and deuterated derivatives. Organic Letters, 2023, 25, 44, 8016-8021.
18) Chunhua Ma, Yu Tian, Junyan Wang, Xing He, Yuqin Jiang*, Bing Yu*, Visible-Light-Driven Transition-Metal-Free Site-Selective Access to Isonicotinamides. Organic Letters, 2022, 24, 8265-8270.
17) Danfeng Wang (本科生), Jin Wang, Chunhua Ma,* Yuqin Jiang,* Bing Yu*, C-3 functionalization of 2-aryl-2H-indazoles under photo/electrocatalysis. Chinese Journal of Organic Chemistry, 2022, 42, 4024-4036.
16) Jin Wang, Qingyuan Song, Xing He, Chunhua Ma,* Yuqin Jiang,* and Jing Fan,* Visible light-promoted, photocatalyst-free decarboxylative alkylation of 2H-indazoles via electron donor-acceptor complex activation. New Journal of Chemistry, 2022, 46, 16436-16439.
15) Chunhua Ma, Hui Meng, Jing Li, Xianguang Yang, Yuqin Jiang*, Bing Yu*, Photocatalytic Transition-Metal-Free Direct 3-Acetalation of Quinoxaline-2(1H)-ones, Chinese Journal of Chemistry, 2022, 40, 2655-2662.
14) Chunhua Ma, Yue Wang, Guang Chen, Jingyi Li, Yuqin Jiang, Xinying Zhang,* and Xuesen Fan*. Divergent construction of 3-(indol-2-yl)succinimide/maleimide and fused benzodiazepine skeletons from 2-(1H-indol-1-yl)anilines and maleimides. Organic Chemistry Frontiers, 2022, 9, 4663-4669.
13) Chunhua Ma, Hui Meng, Xing He, Yuqin Jiang*, Bing Yu*, Visible-Light-Promoted Transition-Metal-Free Construction of 3-Perfluoroalkylated Thioflavones, Frontiers in Chemistry, 2022, 10, 953978.
12) Chunhua Ma, Lu Zhao, Xing He, Yuqin Jiang,* and Bing Yu*, Visible-light-induced direct 3-ethoxycarbonylmethylation of 2-aryl-2H-indazoles in water, Organic Chemistry Frontiers, 2022, 9, 1445-1450.
11）Chunhua Ma, Yu Ji, Jie Zhao, Xing He, Shuting Zhang,* Yuqin Jiang,* and Bing Yu*. Transition-metal-free three-component acetalation-pyridylation of alkenes via photoredox catalysis. Chinese Journal of Catalysis, 2022, 43, 571-583.
10）Dandan Zhang#, Guiqing Xu#, Jie Zhao#, Yue Wang, Xiaofang Wu, Xing He, Wei Li, Shuting Zhang, Shouning Yang, Chunhua Ma*, Yuqin Jiang*, Qingjie Ding*. Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase. European Journal of Medicinal Chemistry, 2021, 225, 113724.
9) Chunhua Ma, Zhiwen Feng, Jing Li, Dandan Zhang, Wei Li, Yuqin Jiang*and Bing Yu*. Photocatalytic Transition-Metal-Free Direct 3-Alkylation of 2-Aryl-2H-Indazoles in Dimethyl Carbonate, Organic Chemistry Frontiers, 2021, 8, 3286-3291.
8）Yuqin Jiang, Jing Li, Zhiwen Feng, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*. Ethylene glycol: a green solvent for visible light-promoted aerobic transition metal-free cascade sulfonation/cyclization reaction, Advanced Synthesis & Catalysis, 2020, 362, 2609-2614.
7）Zhiwen Feng, Jing Li, Yuqin Jiang, Yu Tian, Guiqing Xu, Xin Shi, Qingjie Ding, Wei Li, Chunhua Ma* and Bing Yu*, Transition-metal-free sulfonylations of methylthiolated alkynones to synthesize 3-sulfonylated thioflavones, New Journal of Chemistry, 2020, 44, 14786-14790.
6) Jiaxuan Shen,* Nannan Li, Yanjiang Yu, and Chunhua Ma*. Visible-Light-Induced Oxidation/[3 + 2] Cycloaddition/Oxidative Aromatization to Construct Benzo[a]carbazoles from 1,2,3,4-Tetrahydronaphthalene and Arylhydrazine Hydrochlorides, Organic Letter 2019, 21(17), 7179-7183.
5) Ma, C.; Miao, Y.; Zhao, M.; Wu, P.; Zhou, J.; Li, Z.; Xie, X.; Zhang, W.*, Synthesis of 2-aminothiazoles from styrene derivatives mediated by 1,3-dibromo-5,5-dimethylhydrantoin (DBH). Tetrahedron 2018, 74 (27), 3602-3607.
4) Ma, C.; Fan, G.; Wu, P.; Li, Z.; Zhou, Y.; Ding, Q.; Zhang, W.*, 1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water. Organic & Biomolecular Chemistry 2017, 15 (46), 9889-9894.
3) Ma, C.; Cao, J.; Liang, X.; Huang Y.; Wu, P; Li, Y.; Xu, W.; Zhang, Y.*; Novel leucine ureido derivatives as aminopeptidase N inhibitors. Design, Synthesis and activity evaluation. European Journal of Medicinal Chemistry 2016, 108, 21-27.
2) Ma, C.; Li, X.; liang, X.; Jin, K.; Cao, J.; Xu, W.*, Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry Letters2013, 23 (17), 4948-4952.
1) Ma, C.; Jin, K.; Cao, J.; Zhang, L.; Li, X.; Xu, W.*, Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN). Bioorganic & Medicinal Chemistry 2013, 21 (7), 1621-1627.