个人简介:
刘丙贤,男,博士,副教授,中共党员
电话:15737352811
E-mail: liubx1120@163.com;liubingxian@htu.edu.cn
教育经历:
2006/09-2010/06,山东大学,化学与化工学院,学士
2010/09-2015/06,南开大学,化学学院化学系,博士,导师:王佰全教授
工作经历:
2015.07-2016.07,江苏豪森药业集团有限公司豪森研究院,化学开发员
2016/8-2020/5,河南师范大学,化学化工学院,讲师
2020/6至今,河南师范大学,化学化工学院,副教授
研究领域与兴趣:
1、基于碳氢键活化转化的有机合成方法学及其在药物合成中的应用开发
2、基于廉价金属的不对称碳氢键活化
近年来主持的主要科研项目:
1、国家自然科学基金项目(21801066):基于锰催化C-H键活化环化串联反应的结构多样性吲哚衍生物合成方法研究
2、河南省高等学校重点科研项目(19A150028),锰催化的碳氢键活化环化串联反应研究
3、中国博士后科学基金特别资助(2021T140183),α-甲基碳(硅)手性中心的不对称构建新方法
代表性论文:
16. Zhenzhen Dong,‡ Pengfei Li,‡ Xingwei Li, and Bingxian Liu*, Rh(III)-Catalyzed Diverse C—H Functionalization of Iminopyridinium Ylides, Chin. J. Chem., 2021, 39, 2489.
15. Bingxian Liu,* Pengfei Xie, Jie Zhao, Juanjuan Wang, Manman Wang, Yuqin Jiang, Junbiao Chang,* Xingwei Li*, Rhodium-Catalyzed Enantioselective Synthesis of b-Amino Alcohols via Desymmetrization of gem-Dimethyl Groups, Angew. Chem. Int. Ed., 2021, 60, 8396.
14. Bingxian Liu,* Lingyun Yang, Pengfei Li, Fen Wang, Xingwei Li*, Recent advances in transition metal-catalyzed olefifinic C–H functionalization, Org. Chem. Front., 2021, 8, 1085.
13. Yuqin Jiang, Pengfei Li, Jie Zhao, Bingxian Liu,*Xingwei Li*, Iodonium Ylides as Carbene Precursors in Rh(III)-Catalyzed C−H Activation, Org. Lett., 2020, 22, 7475.
12. Yuqin Jiang, Pengfei Li, Juanjuan Wang, Jie Zhao, Yang Li, Yawen Zhang, Junbiao Chang*, Bingxian Liu*, Xingwei Li*, Rh(III)-Catalyzed Coupling of Acrylic Acids and Ynenones via Olefinic C-H Activation and Michael Addition, Org. Lett., 2020, 22, 438.
11. Bingxian Liu*,Yin Yuan,a Panjie Hu, Guangfan Zheng, Dachang Bai, Junbiao Chang*, Xingwei Li*, Mn(I)-Catalyzed nucleophilic addition/ring expansion via C–H activation and C-C cleavage, Chem. Commun., 2019, 55, 10764.
10. Bingxian Liu, Jie Li, Panjie Hu, Xukai Zhou, Dachang Bai, Xingwei Li*, Divergent Annulative C−C Coupling of Indoles Initiated by Manganese-Catalyzed C−H Activation, ACS Catal., 2018, 8, 9463.
9. Panjie Hu, Ying Zhang, Youwei Xu, Shuang Yang, BingxianLiu*, Xingwei Li*, Construction of (Dihydro)naphtho[1,8-bc]pyrans via Rh(III)-Catalyzed Twofold C−H Activation of Benzoylacetonitriles, Org. Lett., 2018, 20, 2160.
8. Panjie Hu, Ying Zhang, Bingxian Liu*, Xingwei Li*, Facile construction of hydrogenated azepino [3,2,1-hi]indoles by Rh(III)-catalyzed C–H activation/[5+2] annulation of N-cyanoacetylindolines with sulfoxonium ylides, Org. Chem. Front., 2018, 5, 3263.
7. Miaomiao Tian, Bingxian Liu, Jiaqiong Sun, Xingwei Li*, Rh(III)-Catalyzed C-C Coupling of Diverse Arenes and 4-Acyl-1-sulfonyltriazoles via C-H Activation, Org. Lett., 2018, 20, 4946.
6. Bingxian Liu, Panjie Hu, Xukai Zhou, Dachang Bai, Junbiao Chang,* Xingwei Li*, Cp*Rh(III)-Catalyzed Mild Addition of C(sp3)−H Bonds to α,β Unsaturated Aldehydes and Ketones, Org. Lett., 2017, 19, 2086.
5. Bingxian Liu, Panjie Hu, Ying Zhang, Yunyun Li, Dachang Bai, Xingwei Li*, Rh(III)-Catalyzed Diastereodivergent Spiroannulation of Cyclic Imines with Activated Alkenes, Org. Lett., 2017, 19, 5402.
4. Lingheng Kong, Bingxian Liu, Xukai Zhou, Fen Wang, Xingwei Li*, Rhodium(III)-catalyzed regio- and stereoselective benzylic α-fluoroalkenylation with gem-difluorostyrenes, Chem. Commun., 2017, 53, 10326.
3. Bingxian Liu, Bin Li, Baiquan Wang*, Ru(II)-catalyzed amidation reactions of 8-methylquinolines with azides via C(sp3)–H activation, Chem. Commun., 2015, 51, 16334 .
2. Bingxian Liu, Tao Zhou, Bin Li, Shansheng Xu, Haibin Song, Baiquan Wang*, Rhodium(III)-Catalyzed Alkenylation Reactions of 8-Methylquinolines with Alkynes by C(sp3)-H Activation, Angew. Chem. Int. Ed., 2014, 53, 4191.
1. Xing Tan, Bingxian Liu, Xiangyu Li, Bin Li, Shansheng Xu, Haibin Song, Baiquan Wang*, Rhodium-Catalyzed Cascade Oxidative Annulation Leading to Substituted Naphtho[1,8-bc]pyrans by Sequential Cleavage of C(sp2)–H/C(sp3)–H and C(sp2)–H/O–H Bonds, J. Am. Chem. Soc., 2012, 134, 16163.