夏晓华

    主讲本科生《遗传学》、《基因工程》、硕士研究生《生物反应器工程》、《基因工程技术》、《模式鱼类遗传学》、博士研究生《基因工程和分子改造》等课程，并指导多项大学生创新训练项目及大学生生命科学竞赛。主要从事水生动物免疫、性别分化及调控和水生生物生理生态等方面的研究。先后在SCI期刊发表论文四十余篇，主持国家自然科学基金、河南省自然科学基金面上项目、河南省科技攻关项目、横向合作项目等。

1.鱼类生理学与分子生物学：信号通路网络调控鱼类免疫与发育的分子机制；

2.鱼类养殖技术：生殖机制、苗种繁育技术等；

3.功能微生物及免疫蛋白开发：有益菌筛选与健康绿色养殖；鱼类免疫蛋白抑制病原微生物的机制解析和相关功能产品开发。

中国遗传学会会员

中国动物学会会员

1. 
   

   两种泥鳅DMRT1基因不同选择性剪接体的结构、功能及调控机制（31200923），国家自然科学基金青年项目，2013-2015，主持；

2. 抗菌肽BPI在鲤鱼抗病及鱼肉保鲜中的应用研究，河南省高等学校重点科研项目，2026.01-2027.12，主持；

3. TLR21在硬骨鱼类精巢中介导的抗菌免疫防御功能和调控机制研究，河南省自然科学基金面上培育项目，2025.10-2027.10，主持；

4. 新型饲用替抗多肽--杀菌/渗透增强蛋白的功能开发及应用，合肥荣校环保科技有限公司，2025.08-2027.08，主持；

5. 云南大学横向合作项目，2024-2025，主持；

6. 鱼类特有TLRs识别病原体的分子机制及在生殖细胞中的功能研，河南省自然科学基金面上培育项目，2022.01-2023.12，主持；

7. 黄河鲤Toll样受体22病原配体的鉴定及在免疫佐剂中的应用，河南省重点科技攻关项目，2021.01-2022.12，主持；

8. 大鳞副泥鳅DMRT1基因不同选择性剪接体的表达模式分析，河南省教育厅项目，2012-2014，主持；

9. TLRs识别病原体的分子机制及在生殖细胞中的功能研究，河南师范大学面上培育项目2021.01-2023.12，主持；

代表性论文：

1. Yali Wang, Mengzhen Wang, Yanxia Lin, Yunfan Han, Enping Chen, Xiaohua Xia*. TLR5-mediated pathogenic bacteria defense and functional maintenance of Misgurnus anguillicaudatus ovary[J]. Aquaculture, 2026, 615: 743644.

2. Xiaohua Xia, Yanxia Lin, Yali Wang, Lu Qin, Shuang Liu, Hongwei Zhang, Xiaowen Zhang, Yi Li. Antibacterial mechanisms of PLA on Aeromonas hydrophila and its application in fish disease resistance and fish preservation[J]. Food Bioscience, 2025, 65: 106064.

3. Yanxia Lin, Ran Shi, Mengzhen Wang, Yali Wang, Yunfan Han, Yongcui Ma, Liyin Li, Xiaohua Xia*. MCPA-Na exposure in aquatic systems: disruption of pathways and increased susceptibility to infection in fish. Aquatic Toxicology, 2025, 284 :107405.

4. Xiaohua Xia, Xiaoyu Ma, Ning Liang, Lu Qin, Weiran Huo, Yi Li. Effective ways and related mechanisms of Leuconostoc mesenteroides DH purifying PE-MPs in loach (Paramisgurnus dabryanus) to exert protective effects[J]. Aquaculture, 2024, 593: 741265.

5. Xiaohua Xia*, Ning Liang, Xiaoyu Ma, Lu Qin, Zhongjie Chang, Xiaowen Zhang*. Effect of dietary supplementation with Leuconostoc mesenteroides DH on the antimicrobial capacity and overall health of juvenile loach (Misgurnus anguillicaudatus)[J]. Aquaculture, 2024, 579: 740208.

6. Xiaohua Xia, Xiaoyu Ma, Ning Liang, Lu Qin, Weiran Huo, Yi Li*. Damage of polyethylene microplastics on the intestine multilayer barrier, blood cell immune function and the repair effect of Leuconostoc mesenteroides DH in the large-scale loach (Paramisgurnus dabryanus)[J]. Fish and Shellffsh Immunology. 2024, 147: 109460.

7. Weiran Huo, Lu Qin, Wanwan Guo, Xiaowen Zhang, Xiaohua Xia*. Characteristics and functional analysis of a novel mannose receptor in Penaeus vannamei[J]. Fish and Shellffsh Immunology, 2024, 153: 109820.

8. Weiran Huo, Lu Qin, Wanwan Guo, Xiaowen Zhang, Qiyan Du, Xiaohua Xia*. PvMR1, a novel C-type lectin plays a crucial role in the antibacterial immune response of Paciffc white shrimp, Penaeus vannamei[J]. Fish and Shellffsh Immunology, 2024, 145: 109346.

9. Liuen Wang, Meimei Zheng, Jisheng Liu, Zeyu Jin, Cui Wang, Miaomiao Gao, Hongwei Zhang, Xiaowen Zhang, Xiaohua Xia*. LDLa containing C-type lectin mediates phagocytosis of V.anguillarum and regulates immune effector genes in shrimp[J]. Fish and Shellffsh Immunology, 2024, 145: 109361.

10. Yi Li, Mengyuan Qin, Shuo Han, Yuqi Wang, Chao Gao, Wenfang Niu, Xiaohua Xia*. Elimination of Microcystis aeruginosa through Leuconostoc mesenteroides DH and its underlying mechanism[J]. 2024, Science of the Total Environment, 908: 168290.

11. Yi Li, Shuo Han, Yuqi Wang, Mengyuan Qin, Chengjin Lu, Yingke Ma, Wenqing Yang, Jiajia Liu, Xiaohua Xia*. Hailei Wang*. Autoinducer-2 promotes adherence of Aeromonas veronii through facilitating the expression of MSHA type IV pili genes mediated by c-di-GMP[J]. Appl Environ Microbiol. 2023, 89(11): e0081923.

12. Xiaowen Zhang, Manli Shen, Cui Wang, Miaomiao Gao, Liuen Wang, Zeyu Jin, Xiaohua Xia*. Impact of aluminum exposure on oxidative stress, intestinal changes and immune responses in red swamp crayfish (Procambarus clarkii)[J]. 2023, Science of the Total Environment, 855: 158902.

13. Xiaohua Xia, Wanwan Guo, Xiaoyu Ma, Ning Liang, Xiangyu Duan, Peihan Zhang, Ying Zhang, Zhongjie Chang, Xiaowen Zhang*. Reproductive toxicity and cross-generational effect of polyethylene microplastics in Paramisgurnus dabryanus[J]. Chemosphere, 2023, 313: 137440.

14. Xiaohua Xia, Xiaoyu Ma, Ning Liang, Xiangyu Duan, Songyun Wang, Wanwan Guo, Zhongjie Chang*. QNZ exposure induces development toxicity and mechanisms of hatching inhibition in large-scale loach (Paramisgurnus dabryanus) embryos[J]. Ecotoxicology and Environmental Safety, 2023, 253: 114663.

15. Xiaohua Xia, Ning Liang, Xiao-yu Ma, Lu Qin, Song-yun Wang, Zhong-jie Chang*. Inhibition of the NF-kB signaling pathway affects gonadal differentiation and leads to male bias in Paramisgurnus dabryanus.2023, Theriogenology 207: 82-95.

16. Xiaowen Zhang, Zeyu Jin, Manli Shen, Zhongjie Chang, Guoying Yu, Lan Wang, Xiaohua Xia*. Accumulation of polyethylene microplastics induces oxidative stress, microbiome dysbiosis and immunoregulation in crayfish[J]. Fish and Shellfish Immunology, 2022, 125: 276-284.

17. Xiaohua Xia, Gaopeng Liu, Xiaoling Wu, Shuangshuang Cui, CongHui Yang, Qi-yan Du, Xiao-wen Zhang. Effects of Macleaya cordata extract on TLR20 and the proinflammatory cytokines in acute spleen injury of loach (Misgurnus anguillicaudatus) against Aeromonas hydrophila infection[J]. Aquaculture, 2021, 544(299): 737105.

18. Qingyu Sun, Wanwan Guo, Peijin Wang. Zhongjie Chang, Xiaohua Xia*. Qiyan Du. Toxicity of 2-methyl-4-chlorophenoxy acetic acid alone and in combination with cyhalofop-butyl to cyprinus carpio embryos[J]. Environmental Toxicology and Pharmacology, 2021, 87: 103697.

19. Xiaohua Xia, Menghan Sun, Miao Zhou, Zhongjie Chang, Li Li. Polyvinyl chloride microplastics induce growth inhibition and oxidative stress in Cyprinus carpio var. larvae[J]. Science of the Total Environment, 2020, 716: 136479.

20. XiaoWen Zhang, CongHui Yang, HongQuan Zhang, XinTong Pan, ZeYu Jin, HongWei Zhang, XiaoHua Xia*. A C-type lectin with antibacterial activity in weather loach, Misgurnus anguillicaudatus[J]. Journal of Fish Diseases, 2020, 43(12): 1531–1539.

21. Peijin Wang, Ruyan Wan, Weiran Huo, Hui Dong, Zhongjie Chang, Xiaohua Xia*. Cytotoxicity, genotoxicity, oxidative stress, and apoptosis in HepG2 cells induced by the imidazole ionic liquid 1-dodecyl-3-methylimidazolium chloride[J]. Environmental Toxicology, 2020, 35(6): 665-672.

22. Peijin Wang, Qingyu Sun, Ruyan Wan, Qiyan Du, Xiaohua Xia*. Progesterone affects the transcription of genes in the circadian rhythm signaling and hypothalamic-pituitary-gonadal axes and changes the sex ratio in crucian carp (Carassius auratus)[J]. Environmental Toxicology and Pharmacology, 2020, 77: 103378.

23. Xiaohua Xia, Peijin Wang, Ruyan Wan, Zhongjie Chang, Qiyan Du. Progesterone affects sex differentiation and alters transcriptional of genes along circadian rhythm signaling and hypothalamic-pituitary-gonadal axes in juvenile Yellow River Carp (Cyprinus carpio var.)[J]. Environmental Toxicology, 2019, 34: 1255–1262.

24. Weiran Huo, Ruyan Wan, Peijin Wang, Linxia Zhang，Xiaohua Xia*. Molecular cloning, characterization of dax1 gene and its response to progesterone in Misgurnus anguillicaudatus, Drug and Chemical Toxicology, 2019, 42: 6, 624-633.

25. Xiaohua Xia, Ruyan Wan,Peijin Wang, Weiran Huo, Hui Dong, Qiyan Du. Toxicity of imidazoles ionicliquid [C16mim]Cl to Hela cells[J]. Ecotoxicology and Environmental Safety, 2018, 162: 408–414.

26. Ruyan Wan, XiaohuaXia*. Peijin Wang, Weiran Huo, Hui Dong, Zhongjie Chang. Toxicity ofimidazoles ionic liquid [C16mim]Cl to HepG2 cells[J]. Toxicology in Vitro, 2018, 52: 1–7.

27. Xiaohua Xia, Peijin Wang,Ruyan Wan, Weiran Huo, Zhongjie Chang. Toxic effects of cyhalofop-butyl onembryos of the Yellow River Carp (Cyprinus carpio var.): Alters embryoshatching, development failure, mortality of embryos and apoptosis[J]. Environmental science and pollution research. 2018, 25: 24305–24315.

28. Xiaohua Xia, Weiran Huo, Ruyan Wan, Peijin Wang, LinxiaZhang, Zhongjie Chang. Molecular cloning, characterization, and expressionprofiles of the Sox3 gene in Chinese loach Paramisgurnus dabryanus[J]. Evolution& Development, 2018, 20: 108-118.

29. Xiaohua Xia, Weiran Huo, Ruyan Wan, Peijin Wang, ZhongjieChang. Cloning, characterization and function analysis of DAX1 in Chinese loach(Paramisgurnus dabryanus)[J]. Genetica, 2018, 146: 487–496.

30. Xiaohua Xia,Ruyan Wan, Weiran Huo, Linxia Zhang, Xiaopei Xia, Zhongjie Chang. Molecularcloning and mRNA expression pattern of Sox4 in Misgurnus anguillicaudatus[J]. Journal of genetics, 2018, 97(4): 869–877.

著作:

1.《遗传学实验》，第二版，科学出版社，国家级精品课程配套教材，副主编；

2.《基因工程》，第二版，科学出版社，参编；

3. 河南省《基因工程在线精品课程》，主讲。

专利:

1.夏晓华，林彦霞，李鹏飞，霍蔚然。鲤鱼鱼卵凝集素rCcFEL2制备鲤鱼养殖饲料添加剂的应用，中国，2026102195312。

2.夏晓华，林彦霞，霍蔚然，李鹏飞。泥鳅G型溶菌酶rMa-LysG制备泥鳅养殖饲料添加剂的应用，中国，2026100878095。

奖励：

1. 河南省人力资源和社会保障厅授予“嘉奖”；

2. 全国大学生生命科学竞赛一等奖指导教师；

3. 河南省大学生生命科学竞赛一等奖优秀指导教师；

4. 河南省自然科学优秀学术论文一等奖；

5. 河南师范大学青年骨干教师；

6. 河南师范大学研究生优秀指导教师。