教授

陈颖

发布时间:2022-03-04






姓名:陈颖

职称:教授(硕导)

办公电话:0373-3326340

电子邮箱:yingch0816@163.com








个人简介:

2020.4-至今    河南师范大学  生命科学学院  教授

2016.11-2017.12 美国科罗拉多大学安舒茨医学院访问学者

2015.2-2020.3  河南师范大学  生命科学学院  副教授

2007.07-2015.01 河南科技学院生命科技学院  副教授

2003.9-2006.6  山东大学   细胞生物学专业  博士学位

2000.9-2003.7  河南师范大学  动物学专业  硕士学位

主要从事脑血管疾病的发病机制及天然活性物质干预研究。主持国家自然科学基金、河南省自然科学基金及基础与前沿技术等多项研究工作,在《Mol Neurobiology》、《Food & Function》、《Journal of Functional Foods》等杂志发表学术研究论文20余篇,其中SCI源期刊10余篇,一区3篇,二区1篇,《Food & Function》和《Frontiers in Neuroscience》审稿人,授权国家专利3项,优秀学术论文奖4项。河南省教学技能比赛一等奖,获得河南省教学标兵称号。

研究领域:

1.线粒体在脑血管疾病发生中的作用;

2.天然活性产物药理分子基础;

3.纳米载体药物递送。

主要学术及社会兼职:

中国细胞生物学学会会员

主持或参加科研项目情况:

1. EGCG基于S100A10对蛛网膜下腔出血后白质损伤的保护机制研究(HNSJXF-2021-007),河南省神经修复重点实验室开放课题,2022.01-3023.12,主持

2. 基于67LR探讨miR-29a-3p/整合素β1介导的EGCG干预蛛网膜下腔出血后神经功能损伤的机制研究(182300410299),河南省自然科学基金,2018.01-2019.12,主持

3. EGCG 受体在星形胶质细胞中的确证及其跨膜作用机制研究(31200519),国家自然科学基金,2013.01-2015.12, 主持

4. 67LamR介导的EGCG神经保护功能研究,河南省基础与前言技术研究计划,2013.01-2015.12,主持

5. 食品质量与安全,河南省高校科技创新团队,2015.01-2017.12,参与

学术成果:

代表性论文: 

1. Chen Y*, Huang LY, Zhang HY, Diao XL, Zhao SY, Zhou WK. Reduction in autophagy by (-)-Epigallocatechin-3-3Gallate (EGCG): a potential mechanism of prevention of mitochondrial dysfunction after subarachnoid hemorrhage. Mol Neurobiol2017, 54(1): 392-405. (二区 IF 6.19)

2. Chen Y*, Chen JJ, Sun XX, Shi XX, Wang L, Huang LY, Zhou WK. Evaluation ofthe neuroprotective effect of EGCG: a potential mechanism of mitochondrial dysfunction and mitochondrial dynamics after subarachnoid hemorrhage. Food Funct 2018, 9(12): 6349-6359. (一区)

3. Chen Y*, Huang LY, Wang L, Chen LY, Ren WH, Zhou WK. Differential expression of microRNAs contributed to the health efficacy of EGCG in in vitro subarachnoid hemorrhage model. Food Funct 2017, 8: 4675-4683. (一区)

4. Chen Y*, Huang LY, Zhang HY, Sun HY, Zhou WK. EGCG protective mitochondrial dysfunction after subarachnoid haemorrhage via inhibition p38α pathway. J Funct Foods 2016, 23: 115-123. (一区)

5. Zhang YY, Han MG, Sun XX, Gao GJ, Yu GY, Huang LY, Chen Y*. EGCG promotes neurite outgrowth through the integrin β1/FAK/p38 signaling pathway after subarachnoid hemorrhage. Evid Based Complement Alternat Med 2021, 2021:8810414.

6. Miao YH,Sun XX, Gao GJ, Jia XL, Wu H, Chen Y, Huang LY. Evaluation of(-)-epigallocatechin-3-gallate (EGCG)-induced cytotoxicity on astrocytes: A potential mechanism of calcium overloading-induced mitochondrial dysfunction.Toxicology in Vitro 2019, 61: 104592.

7. Huang LY,Hou YQ,Wang L, Xu XH, Guan QK, Li XS, Chen Y, Zhou  WK*. p38 inhibitor protects mitochondrial dysfunction by induction of DJ-1 mitochondrial translocation after subarachnoid hemorrhage. J Mol Neurosci 2018, 66(2):  163-171.

8. Chen Y, Sun HY, Huang LY*, Li JX, Zhou WK, Chang JL.Neuroprotective effect of radix trichosanthis saponins on subarachnoid hemorrhage. Evid Based Complement Alternat Med 2015, 2015: 313657.

9. Chen Y, Miao YH, Huang LY, Li JX, Sun HY, Zhao YZ, Yang J, Zhou WK. Antioxidant activities of saponins extracted from Radix Trichosanthis: an in vivo and invitro evaluation. BMC Complem Altern M 2014, 14: 86.

10. Chen Y, Zhang HY, Yang J, Sun HY. Improved antioxidant capacity of optimization of a self-microemulsifying drug delivery system for resveratrol. Molecules 2015, 20: 21167-21177.

11. Mo HZ,Chen Y*, Huang LY, Zhang H, Li JX, Zhou WK. Neuroprotective effect of tea polyphenols on oxyhemoglobin induced subarachnoid hemorrhage in mice.Oxid Med Cell Longe 2013, 2013: 743938.

12. Huang LY, Wan J, Chen Y, Wang ZW, Hui L, Li Y, Xu DW, Zhou WK*. Inhibitory effects of p38 inhibitor against mitochondrial dysfunction after subarachnoid hemorrhage in mice. Brain Res2013, 1517:  133-140.

13. Chen YH, Chen Y, Huang LY, Yu JB. Evaluation of heparanase and matrix metalloproteinase-9 in patients with cutaneous malignant melanoma. J Dermatol 2012, 39: 339-343.

14. Zhang HY, Chen Y, Fan BL, Wang WF, Zhu WL. Overexpression of VEGF183 promotes murine breast cancer cell proliferation in vitro and induces dilated intratumoral microvessels. Tumor Biol 2015, 36: 3871-3880.

专利成果:

1. 从天花粉中综合提取多种生物活性成分的方法,国家发明专利(授权),ZL201410291925.6

2. 天花粉皂苷及其在制备治疗缺血性脑血管疾病中的应用,国家发明专利(授权),ZL201010537400.8

3. 抗癌药物组合物,国家发明专利(授权),ZL2004100359256